Iain Mattaj

Prof. Mattaj has a degree in biochemistry from the University of Edinburgh (BSc) and he obtained a PhD from the University of Leeds in 1980 for research on cloned Glutamate dehydrogenase (GDH) genes supervised by John Wooton.

He carried out his postdoctoral research at the Friedrich Miescher Institute (CH) and then at the Biocentre, University of Basel. There he worked in the laboratory of Eddy De Robertis and established the research areas he would continue to pursue. In 1985 he moved to EMBL where he took up the position of Group Leader at the Heidelberg Laboratory. In the following years he became Coordinator of the Gene Expression Unit (1990) and then Scientific Director of EMBL (1999) until his appointment as Director General of EMBL (2005).{{Cite web|title=Iain Mattaj|url=https://humantechnopole.it/en/people/iain-mattaj/|access-date=2021-05-05|website=Human Technopole|language=en-US|archive-date=5 May 2021|archive-url=https://web.archive.org/web/20210505102250/https://humantechnopole.it/en/people/iain-mattaj/|url-status=dead}}

Mattaj has made a number of important contributions to our knowledge concerning how RNA and proteins are transported between the cell nucleus and cytoplasm. These findings stemmed from his early work on the import and export of ribonucleoproteins — RNA–protein complexes — to and from the cell nucleus.

Prof. Mattaj subsequently uncovered the role of enzymes known as GTPases in the regulation of mitosis — the division of the cell nucleus into two daughter nuclei. Under the influence of Ran, a GTPase signaling protein, the cell cytoskeleton remodels to form the mitotic spindle — a crucial structure in mitosis. Ran also has an important role in nuclear envelope assembly at the end of mitosis. By dissecting Ran's role in facilitating mitosis, Iain is enabling researchers to create improved cell-regeneration therapies.{{cite journal|last1=Fornerod|first1=Maarten|last2=Ohno|first2=Mutsuhito|last3=Yoshida|first3=Minoru|last4=Mattaj|first4=Iain W.|title=CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals|journal=Cell|volume=90|issue=6|year=1997|pages=1051–1060|doi=10.1016/S0092-8674(00)80371-2|pmid=9323133|s2cid=15119502|doi-access=free}}{{cite journal|last1=Mattaj|first1=Iain W.|last2=Englmeier|first2=Ludwig|title=NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase|journal=Annual Review of Biochemistry|volume=67|issue=1|year=1998|pages=265–306|doi=10.1146/annurev.biochem.67.1.265|pmid=9759490|doi-access=free}}

Mattaj was elected a Fellow of the Royal Society (FRS) in 1999,{{cite web|archive-url=https://web.archive.org/web/20151117000957/https://royalsociety.org/people/iain-mattaj-11911/ |archive-date=2015-11-17 |url=https://royalsociety.org/people/iain-mattaj-11911/ |website=royalsociety.org |publisher=Royal Society |location=London |year=1999 |author=Anon |title=Professor Iain Mattaj FRS }} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{blockquote|“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --{{cite web|url=https://royalsociety.org/about-us/terms-conditions-policies/ |title=Royal Society Terms, conditions and policies |access-date=2016-03-09 |url-status=bot: unknown |archive-url=https://web.archive.org/web/20150925220834/https://royalsociety.org/about-us/terms-conditions-policies/ |archive-date=September 25, 2015 }}}} a Fellow of Academia Europaea in 1999, a Fellow of the Royal Society of Edinburgh in 2000, a Fellow of the American Academy of Arts and Sciences in 2001, a Fellow of the Deutsche Akademie der Naturforscher Leopoldina in 2005, a Fellow of the Academy of Medical Sciences FmedSci,{{Cite web|title=Professor Iain Mattaj {{!}} The Academy of Medical Sciences|url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Iain%20William-Mattaj-0033z00002qIKzpAAG|access-date=2021-05-05|website=acmedsci.ac.uk}} FmedSci, in 2016 and a Foreign Associate of the National Academy of Sciences (USA) in 2017. In 2001 he was awarded the Louis-Jeantet Prize for Medicine.{{Cite web|last=admin|date=2017-10-01|title=Doctor Iain W. MATTAJ {{!}} Jeantet|url=https://www.jeantet.ch/en/prix-louis-jeantet/laureats/2001-en/docteur-iain-w-mattaj/|access-date=2021-05-05|language=en-US}} Over the years he has received Honorary Doctorates from the University of Edinburgh, the University of Dundee, Umea University and the University of Leeds. He was Editor of EMBO Journal from 1991-2004 and since 2017 he is Chair of the Board of Trustees of the Darwin Trust.{{Cite web|url=https://darwintrust.bio.ed.ac.uk/trustees|access-date=2021-05-05|website=darwintrust.bio.ed.ac.uk}} In September 2021, during a ceremony at EMBL Heidelberg, Prof Mattaj received the Verdienstkreuz for his commitment to science.{{Cite web|date=2021-09-09|title=German Cross of Merit for former EMBL Director General|url=https://www.embl.org/news/alumni/cross-of-merit-for-iain-mattaj/|access-date=2021-09-27|website=EMBL|language=en-US}} In the same month he was also elected as a member of the Royal Swedish Academy of Sciences to the class for Biosciences.{{Cite web|title=Kungl Vetenskapsakademien|date=19 September 2021 |url=https://www.kva.se/en/nyheter/atta-nya-utlandska-ledamoter-invalda-i-vetenskapsakademien}}

{{reflist|35em}}

{{FRS 1999}}

{{Authority control}}

{{DEFAULTSORT:Mattaj, Iain}}

Category:1952 births

Category:Living people

Category:Fellows of the Royal Society

Category:Fellows of the Royal Society of Edinburgh

Category:Foreign associates of the National Academy of Sciences

Category:Members of Academia Europaea

Category:Members of the European Molecular Biology Organization

Category:Alumni of the University of Edinburgh

Category:Alumni of the University of Leeds

Category:British biologists