Iain McInnes

McInnes's research has investigated the role of cytokines and their inflammation amplification role in immune-mediated inflammatory disease (IMID) pathogenesis. His early work focused on defining the roles played by novel cytokines in driving inflammatory synovitis, including the effector functions of IL-15, IL-18, and IL-33 in rheumatoid (RA) and psoriatic arthritis (PsA) synovitis.{{cite journal | url=https://pubmed.ncbi.nlm.nih.gov/9018238/ | pmid=9018238 | date=1997 | last1=McInnes | first1=I. B. | last2=Leung | first2=B. P. | last3=Sturrock | first3=R. D. | last4=Field | first4=M. | last5=Liew | first5=F. Y. | title=Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis | journal=Nature Medicine | volume=3 | issue=2 | pages=189–195 | doi=10.1038/nm0297-189 }}{{cite journal | pmid=10562301 | date=1999 | last1=Gracie | first1=J. A. | last2=Forsey | first2=R. J. | last3=Chan | first3=W. L. | last4=Gilmour | first4=A. | last5=Leung | first5=B. P. | last6=Greer | first6=M. R. | last7=Kennedy | first7=K. | last8=Carter | first8=R. | last9=Wei | first9=X. Q. | last10=Xu | first10=D. | last11=Field | first11=M. | last12=Foulis | first12=A. | last13=Liew | first13=F. Y. | last14=McInnes | first14=I. B. | title=A proinflammatory role for IL-18 in rheumatoid arthritis | journal=The Journal of Clinical Investigation | volume=104 | issue=10 | pages=1393–1701 | doi=10.1172/JCI7317 | pmc=409841 }}{{cite journal | url=https://pubmed.ncbi.nlm.nih.gov/20139274/ | pmid=20139274 | date=2010 | last1=Xu | first1=D. | last2=Jiang | first2=H. R. | last3=Li | first3=Y. | last4=Pushparaj | first4=P. N. | last5=Kurowska-Stolarska | first5=M. | last6=Leung | first6=B. P. | last7=Mu | first7=R. | last8=Tay | first8=H. K. | last9=McKenzie | first9=A. N. | last10=McInnes | first10=I. B. | last11=Melendez | first11=A. J. | last12=Liew | first12=F. Y. | title=IL-33 exacerbates autoantibody-induced arthritis | journal=Journal of Immunology | volume=184 | issue=5 | pages=2620–2626 | doi=10.4049/jimmunol.0902685 }} His studies also examined the cytokine-driven cellular interactions between T cells, macrophages, and synovial fibroblasts, particularly the role of non-antigen dependent amplification of synovial inflammation.{{cite journal | pmid=11094451 | date=2000 | last1=McInnes | first1=I. B. | last2=Leung | first2=B. P. | last3=Liew | first3=F. Y. | title=Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells | journal=Arthritis Research | volume=2 | issue=5 | pages=374–378 | doi=10.1186/ar115 | doi-access=free | pmc=130139 }}{{cite journal | url=https://www.nature.com/articles/nri2094#:~:text=Cytokines%20are%20implicated%20in%20each,destruction%20of%20adjacent%20joint%20tissue | doi=10.1038/nri2094 | title=Cytokines in the pathogenesis of rheumatoid arthritis | date=2007 | last1=McInnes | first1=Iain B. | last2=Schett | first2=Georg | journal=Nature Reviews Immunology | volume=7 | issue=6 | pages=429–442 | pmid=17525752 }}

Subsequently, his research identified several novel synovial cytokine amplificatory pathways involved in disease chronicity, such as PAR2 dependent matrix enzyme sensing,{{cite journal | url=https://ard.bmj.com/content/71/6/1049 | pmid=22294633 | date=2012 | last1=Crilly | first1=A. | last2=Burns | first2=E. | last3=Nickdel | first3=M. B. | last4=Lockhart | first4=J. C. | last5=Perry | first5=M. E. | last6=Ferrell | first6=P. W. | last7=Baxter | first7=D. | last8=Dale | first8=J. | last9=Dunning | first9=L. | last10=Wilson | first10=H. | last11=Nijjar | first11=J. S. | last12=Gracie | first12=J. A. | last13=Ferrell | first13=W. R. | last14=McInnes | first14=I. B. | title=PAR(2) expression in peripheral blood monocytes of patients with rheumatoid arthritis | journal=Annals of the Rheumatic Diseases | volume=71 | issue=6 | pages=1049–1054 | doi=10.1136/annrheumdis-2011-200703 | pmc=4861243 }} and autoantibody to MICL mediated monocyte activation.{{cite journal | url=https://ard.bmj.com/content/75/7/1386 | pmid=26275430 | doi=10.1136/annrheumdis-2014-206644 | title=MICL controls inflammation in rheumatoid arthritis | date=2016 | last1=Redelinghuys | first1=Pierre | last2=Whitehead | first2=Lauren | last3=Augello | first3=Andrea | last4=Drummond | first4=Rebecca A. | last5=Levesque | first5=Jean-Michel | last6=Vautier | first6=Simon | last7=Reid | first7=Delyth M. | last8=Kerscher | first8=Bernhard | last9=Taylor | first9=Julie A. | last10=Nigrovic | first10=Peter A. | last11=Wright | first11=John | last12=Murray | first12=Graeme I. | last13=Willment | first13=Janet A. | last14=Hocking | first14=Lynne J. | last15=Fernandes | first15=Maria J G. | last16=De Bari | first16=Cosimo | last17=McInnes | first17=Iain B. | last18=Brown | first18=Gordon D. | journal=Annals of the Rheumatic Diseases | volume=75 | issue=7 | pages=1386–1391 | pmc=4941174 }} These studies have contributed to the understanding of the cellular and molecular mechanisms underlying inflammatory synovial disease.{{cite web | url=https://scholar.google.com/citations?user=BQAh1-UAAAAJ&hl=en | title=I McInnes }}

McInnes is Vice Principal and Head of the College of Medical, Veterinary and Life Sciences, Muirhead Chair of Medicine and Versus Arthritis Professor of Rheumatology at the University of Glasgow.{{Cite web|url=https://www.medpagetoday.com/reading-room/aad/psoriasis/105580|title=AAD Reading Room | Iain McInnes, MD, on the Latest Findings on Bimekizumab for Psoriatic Arthritis | MedPage Today}}

He is past Chairman of the FOREUM (Foundation for European Rheumatology Research) Scientific Committee. From 2019 to 2021, he was President of EULAR,{{cite web | url=https://trasd.org.tr/haber/eular-message-from-the-president-professor-iain-mcinnes | title=EULAR Message from the President, Professor Iain McInnes | Türkiye Romatizma Araştırma ve Savaş Derneği }} the leading transnational society for rheumatology across Europe, during which time he founded the European Rheumatology Research Centre,{{cite journal | url=https://rmdopen.bmj.com/content/8/2/e002456 | pmid=35714997 | doi=10.1136/rmdopen-2022-002456 | title=Levelling the playing field of RMD research across Europe to address patients' needs: The emerging EULAR Research Centre | date=2022 | last1=Reuter | first1=Katja | last2=Haupt | first2=Carina | last3=Molto | first3=Anna | last4=Cope | first4=Andrew | last5=Van Vollenhoven | first5=Ronald F. | last6=Elewaut | first6=Dirk | last7=Lories | first7=Rik | last8=McInnes | first8=Iain B. | journal=RMD Open | volume=8 | issue=2 | pages=e002456 | pmc=9207999 }} and established pan-European COVID-19 registries to define SARS-CoV-2 risk and vaccine efficacy across IMIDs. He chaired the UK Government’s Independent Advisory Group for strategies to support immune vulnerable patient groups during the COVID-19 pandemic.{{cite web | url=https://www.gov.uk/government/publications/higher-risk-patients-eligible-for-covid-19-treatments-independent-advisory-group-report/defining-the-highest-risk-clinical-subgroups-upon-community-infection-with-sars-cov-2-when-considering-the-use-of-neutralising-monoclonal-antibodies | title=Defining the highest-risk clinical subgroups upon community infection with SARS-CoV-2 when considering the use of neutralising monoclonal antibodies (NMABs) and antiviral drugs: Independent advisory group report }}

He is Director of the Versus Arthritis Centre of Excellence for Inflammatory Arthritis, led from Glasgow and including Universities of Oxford, Newcastle, and Birmingham.{{cite web | url=https://www.heraldscotland.com/news/13147270.determined-doctors-quest-inspired-patients-battles/ | title=Determined doctor's quest is inspired by patients' battles | date=24 February 2014 }} He was Chief Investigator of the IMID-Bio-UK meta-consortium leading the UK effort to discover precision medicine tractable biomarkers for application in immune diseases.{{cite web | url=https://www.manchester.ac.uk/discover/news/universities-to-create--worlds-largest-inflammatory-disease-biobank/ | title=Universities to create world's largest inflammatory disease biobank }}

He is Associate Editor of Annals of the Rheumatic Diseases{{cite web |title="Professor Iain B McInnes - Eminent Consortium - UCL - University College London" |date= 25 February 2019|url= https://www.ucl.ac.uk/eminent-consortium/key-people/mcinnes}} and Editor in Chief of Firestein & Kelley's Textbook of Rheumatology.{{cite book |title="Kelley's Textbook of Rheumatology - ScienceDirect" |isbn= 978-1-4377-1738-9|url= https://www.sciencedirect.com/book/9781437717389/kelleys-textbook-of-rheumatology#book-description|last1= Firestein|first1= Gary S.|last2= Kelley|first2= William N.|date= 10 April 2024|publisher= Elsevier Health Sciences}}

• Chairperson of the NIHR Biorepository Governance Oversight Board (2021 - present){{Cite web|url=https://bioresource.nihr.ac.uk/about-us/oversight-board/|title=Oversight Board|website=bioresource.nihr.ac.uk}}
• MRC Experimental Medicine Board (Deputy Chair) (2020–2024){{Cite web|url=https://www.ukri.org/who-we-are/mrc/board-and-panel-membership/experimental-medicine-panel/|title=Experimental Medicine Panel|website=www.ukri.org}}
• Versus Arthritis Trustee (2021–present){{Cite web|url=https://versusarthritis.org/about-us/our-organisation/trustees/|title=Trustees and Co-optees|website=Versus Arthritis}}
• NHS Greater Glasgow & Clyde Health Board Member (2021–present){{Cite web|url=https://www.nhsggc.scot/page_category/nhs-board/page/4/|title=NHS Board Archives - Page 4 of 5 - NHSGGC}}
• Past-President of European Alliance of Rheumatology Associations (EULAR) (2019–2021){{Cite web|url=https://www.esanum.fr/conferences/eular2021|title=EULAR 2021|website=www.esanum.fr}}
• Board member, Foreum Research Foundation (2023 – present){{Cite web|url=https://www.foreum.org/operational_structure.cfm|title=FOREUM – Operational structure|website=www.foreum.org}}
• Member of Lister Prize Committee (2021–present){{Cite web|url=https://lister-institute.org.uk/scientific-advisory-committee/|title=Scientific Committee}}

McInnes was made of Commander of the Most Excellent Order of the British Empire (CBE) for services to medicine by Her Majesty the Queen in 2019.{{cite web | url=https://www.heraldscotland.com/news/17325345.trio-honoured-work-university-glasgow/ | title=Trio honoured for work at University of Glasgow | date=29 December 2018 }}

He is a Fellow of the Academy of Medical Sciences, a Fellow of the Royal Society of Edinburgh, and an Elected Member of Academia Europaea.{{cite web | url=https://www.ae-info.org/ae/Member/McInnes_Iain | title=Academy of Europe: McInnes Iain }} He is a Fellow of the Royal College of Physicians of Edinburgh and a Fellow of the Royal College of Physicians and Surgeons of Glasgow.

He is the recipient of the Sir James Black Medal of the Royal Society of Edinburgh for "outstanding contribution to the field of immunology" (2017),{{Cite web|url=https://rse.org.uk/funding-collaboration/award/rse-sir-james-black-medal/|title=RSE Sir James Black Medal|website=Royal Society of Edinburgh}} the Heberden Medal of the British Society for Rheumatology (2018), and the Carol-Nachman Prize for Rheumatology in Germany (2019).{{Cite web|url=https://www.gla.ac.uk/news/archiveofnews/2019/june/headline_647140_en.html|title=UofG Professor awarded one of Germany's most prestigious medical prizes|website=www.gla.ac.uk}} Other awards include the Royal Philosophical Society of Glasgow's Thomas Graham Medal (2022),{{cite web |title=Members' Newsletter Royal Philosophical Society |url= https://www.royalphil.org/wp-content/uploads/2022/10/RPSG-Newsletter-No1.pdf

}} Tenovus Scotland's Lady Margaret McLellan Award (2016),{{Cite web|url=https://rcpsg.ac.uk/documents/career-support/awards-and-scholarships/911-lady-margaret-maclellan-award-notice-2018/file|title=Tenovus Scotland}} the Laurentian Society’s JL Demers Award in Canada (2017),{{Cite web|url=https://conferencelaurentienne.ca/prizes-2/|title=Awards}} and the British Society for Rheumatology’s Michael Mason Prize (2001).Plenary Session (including the Michael Mason Prize winner) (Abstracts 179-185), Rheumatology, Volume 40, Issue suppl_1, April 2001, Pages 63–65

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Category:1964 births

Category:Living people

Category:British rheumatologists

Category:British medical academics