Iflaviridae

File:JVI.00680-16_F1.large.jpg (SBPV) virion and the icosahedral asymmetric unit. Genome map.]]

File:OPSR.Ifl.Fig1.v1.png (IFV) virion and the icosahedral asymmetric unit.]]

File:OPSR.Ifl.Fig2.Iflaviridae v3.png-640x480.png

Members of this family are insect-infecting viruses that consist of positive single-strand RNA genomes translated into a single polyprotein of ~3000 amino acids long. It encodes helicase, protease and RNA-dependent RNA polymerase enzymes and four structural proteins (VP1–4). The non-enveloped capsid has an icosahedral T=pseudo3 symmetry and is around 30 nm in diameter. VP1, VP2 and VP3 form the outer portion, with VP4 located internally. Genomes are linear and non-segmented, around 8.8-9.7kb in length.

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment to host receptors, which mediates endocytosis. Replication follows the positive stranded RNA virus replication model. Positive stranded RNA virus transcription is the method of transcription. Translation takes place by ribosomal skipping. Insects serve as the natural host.

Several viruses in this family are economically important because they are highly pathogenic to their honeybee and silkworm hosts, while others (including Dinocampus coccinellae paralysis virus, Nasonia vitripennis virus and Venturia canescens picorna-like virus) appear to cause little or no symptoms.{{citation|vauthors=Dheilly NM, Maure F, Ravallec M |title=Who is the puppet master? Replication of a parasitic wasp-associated virus correlates with host behaviour manipulation |journal=Proceedings of the Royal Society B |doi=10.1098/rspb.2014.2773|display-authors=etal |volume=282 |issue=1803 |pages=20142773 |pmid=25673681 |pmc=4345448 |year=2015}}

The family Iflaviridae contains one genus, Iflavirus, with the following 16 species, listed by scientific name and followed by the exemplar virus of the species:{{cite web|title=Virus Taxonomy: 2024 Release|url=https://ictv.global/taxonomy|publisher=International Committee on Taxonomy of Viruses|access-date=20 March 2025}}

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• Iflavirus achedomestici, Acheta domesticus iflavirus
• Iflavirus aladeformis, Deformed wing virus
• Iflavirus apistardum, Slow bee paralysis virus
• Iflavirus betaspexiguae, Spodoptera exigua iflavirus 2
• Iflavirus brebrassicae, Brevicoryne brassicae virus
• Iflavirus dinococcinellae, Dinocampus coccinellae paralysis virus
• Iflavirus ectobliquae, Ectropis obliqua virus
• Iflavirus flacherie, Infectious flacherie virus
• Iflavirus lineacelli, Lymantria dispar iflavirus 1
• Iflavirus lylineolaris, Lygus lineolaris virus 1
• Iflavirus nilalugentis, Nilaparvata lugens honeydew virus 1
• Iflavirus pernudae, Perina nuda virus
• Iflavirus sacbroodi, Sacbrood virus
• Iflavirus spexiguae, Spodoptera exigua iflavirus 1
• Iflavirus vadestruente, Varroa destructor iflavirus 1
• Iflavirus vomitus, Antheraea pernyi iflavirus

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{{Reflist}}

• [http://www.ictv.global/report/iflaviridae ICTV Online (10th) Report; Iflaviridae]
• [https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/picornavirales/w/iflaviridae ICTV Online (10th) Report; Iflaviridae, alternative link] {{Webarchive|url=https://web.archive.org/web/20170913230747/https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/picornavirales/w/iflaviridae |date=13 September 2017 }}
• [http://viralzone.expasy.org/all_by_species/278.html Viralzone: Iflavirus]

{{Baltimore classification}}

{{Taxonbar|from=Q5991208}}

Category:Picornavirales

Category:Virus families