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|Description=Diagnostic of pathogenic mutations. A diagnostic complex is a dsDNA molecule resembling a short part of the gene of interest, in which one of the strands is intact (diagnostic signal) and the other bears the mutation to be detected (mutation signal). In case of a pathogenic mutation, the transcribed mRNA pairs to the mutation signal and triggers the release of the diagnostic signal

|Source=Martinez-Perez, I.M., Zhang, G., Ignatova, Z., Zimmermann, K.-H.: Computational genes: a tool for the molecular diagnosis and therapy of aberrant mutational phenotype. BMC Bioinformatics 2007, 8:365.

|Date=28 September 2008

|Location=http://www.biomedcentral.com/1471-2105/8/365

|Author=Martinez-Perez et al.

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