Impute.me

Impute.me was an open-source non-profit web application that allowed members of the public to use their data from direct-to-consumer (DTC) genetic tests (including tests from 23andMe and Ancestry.com) to calculate polygenic risk scores (PRS) for complex diseases and cognitive and personality traits.{{Cite journal|last1=Folkersen|first1=Lasse|last2=Pain|first2=Oliver|last3=Ingason|first3=Andrés|last4=Werge|first4=Thomas|last5=Lewis|first5=Cathryn M.|last6=Austin|first6=Jehannine|author-link6=Jehannine Austin|date=2020|title=Impute.me: An Open-Source, Non-profit Tool for Using Data From Direct-to-Consumer Genetic Testing to Calculate and Interpret Polygenic Risk Scores|journal=Frontiers in Genetics|volume=11|pages=578|doi=10.3389/fgene.2020.00578|issn=1664-8021|pmc=7340159|pmid=32714365|doi-access=free}}{{cite journal |vauthors=Brockman DG, Petronio L, Dron JS, Kwon BC, Vosburg T, Nip L, Tang A, O'Reilly M, Lennon N, Wong B, Ng K, Huang KH, Fahed AC, Khera AV |title=Design and user experience testing of a polygenic score report: a qualitative study of prospective users |journal=BMC Med Genomics |volume=14 |issue=1 |pages=238 |date=October 2021 |pmid=34598685 |pmc=8485114 |doi=10.1186/s12920-021-01056-0 |url= |doi-access=free }}{{cite journal| author=Ronald A| title=Editorial: Polygenic scores in child and adolescent psychiatry - strengths, weaknesses, opportunities and threats. | journal=J Child Psychol Psychiatry | year= 2020 | volume= 61 | issue= 5 | pages= 519–521 | pmid=32304105 | doi=10.1111/jcpp.13246 | pmc= | s2cid=215810502 | doi-access=free }}{{cite journal| author=Corpas M, Beck S, Glusman G, Shabani M| title=Editorial: Personal Genomes: Accessing, Sharing, and Interpretation. | journal=Front Genet | year= 2021 | volume= 12 | issue= | pages= 687584 | pmid=34149819 | doi=10.3389/fgene.2021.687584 | pmc=8213362 | doi-access=free }}{{cite journal| author=Zanardi R, Prestifilippo D, Fabbri C, Colombo C, Maron E, Serretti A| title=Precision psychiatry in clinical practice. | journal=Int J Psychiatry Clin Pract | year= 2021 | volume= 25 | issue= 1 | pages= 19–27 | pmid=32852246 | doi=10.1080/13651501.2020.1809680 | pmc= | s2cid=221347950 | url=https://pubmed.ncbi.nlm.nih.gov/32852246 }} In July 2022, Lasse Folkerson, initiator and operator of impute.me, took the website offline.{{Cite tweet |user=ImputeMe |number=1547639111539822593 |title=We are undergoing an evolution to the next level of easy-to-access, high-quality genetic analysis.}}{{Cite tweet |user=lassefolkersen |number=1547637066384560137 |title=Start spreading the news, I'm leaving today.}}

{{infobox biodatabase

|title = impute.me

|logo =

|description = A polygenic risk score calculator for human diseases and traits

|scope = single-nucleotide polymorphisms, genotypes, genes, variation

|organism = Homo sapiens

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|pmid = 32714365

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|url = {{dead link|date=October 2022}}{{URL|https://www.impute.me}}

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|webservice =

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|webapp =

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|license = GNU Lesser General Public License v3.0

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Impute.me calculates PRSs, which are used to estimate the risk of developing complex diseases from the combined effects of numerous common single nucleotide polymorphisms in the human genome.{{cite journal| author=Wray NR, Lin T, Austin J, McGrath JJ, Hickie IB, Murray GK | display-authors=etal| title=From Basic Science to Clinical Application of Polygenic Risk Scores: A Primer. | journal=JAMA Psychiatry | year= 2021 | volume= 78 | issue= 1 | pages= 101–109 | pmid=32997097 | doi=10.1001/jamapsychiatry.2020.3049| issn=2168-622X | pmc= | s2cid=222169651| url=https://pubmed.ncbi.nlm.nih.gov/32997097 }}{{cite journal| author=Murray GK, Lin T, Austin J, McGrath JJ, Hickie IB, Wray NR| title=Could Polygenic Risk Scores Be Useful in Psychiatry?: A Review. | journal=JAMA Psychiatry | year= 2021 | volume= 78 | issue= 2 | pages= 210–219 | pmid=33052393 | doi=10.1001/jamapsychiatry.2020.3042 | pmc= | s2cid=222351995 | url=https://pubmed.ncbi.nlm.nih.gov/33052393 }}

It is intended for use by people who have obtained genetics data from a direct to consumer genetic testing company.{{cite web| author=France2 | title=ADN pour tous | website=YouTube | year= 2018 | url=https://www.youtube.com/watch?v=xl10P__EAF4&t=3275s }}{{cite journal| author=Vanzo RJ, Prasad A, Staunch L, Hensel CH, Serrano MA, Wassman ER | display-authors=etal| title=The Temple Grandin Genome: Comprehensive Analysis in a Scientist with High-Functioning Autism. | journal=J Pers Med | year= 2020 | volume= 11 | issue= 1 | page=21| pmid=33383702 | doi=10.3390/jpm11010021 | pmc=7824360 | doi-access=free}} If they upload the files, the uploaded data is expanded into ungenotyped SNPs and the overlap with public GWAS summary statistics used to estimate risk. The data is then subjected to analysis scripts including PRS calculations for approximately 2,000 traits and complex diseases. PRSs are calculated based on the combined effect of all SNPs reported in the summary statistics of the underlying GWAS or of the top, genome-wide significant SNPs in the underlying GWAS. The scores based on all SNPs are only available for about 20 complex diseases and traits. Users can then make use of the web tool GenoPred{{Cite web|title=Converting Polygenic Score to Absolute Scale|url=https://opain.github.io/GenoPred/PRS_to_Abs_tool.html|access-date=2021-09-02|website=opain.github.io}} to translate their PRSs onto an absolute risk scale using summary statistics from the GWAS studies.{{Cite medRxiv |last1=Pain |first1=Oliver |last2=Gillett |first2=Alexandra C. |last3=Austin |first3=Jehannine C. |last4=Folkersen |first4=Lasse |last5=Lewis |first5=Cathryn M. |date=2021-04-20 |title=A Tool for Translating Polygenic Scores onto the Absolute Scale Using Summary Statistics |language=en |medrxiv=10.1101/2021.04.16.21255481v1}}