InaD-like protein

This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.{{cite web | title = Entrez Gene: INADL InaD-like (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10207}}

INADL has been shown to interact with MPP5.{{cite journal | vauthors = Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B | title = The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost | journal = J. Cell Biol. | volume = 157 | issue = 1 | pages = 161–72 | date = Apr 2002 | pmid = 11927608 | pmc = 2173254 | doi = 10.1083/jcb.200109010 }}

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Fanning AS, Anderson JM | title = PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane | journal = J. Clin. Invest. | volume = 103 | issue = 6 | pages = 767–72 | year = 1999 | pmid = 10079096 | pmc = 408156 | doi = 10.1172/JCI6509 }}
• {{cite journal | vauthors = Lennon G, Auffray C, Polymeropoulos M, Soares MB | title = The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression | journal = Genomics | volume = 33 | issue = 1 | pages = 151–2 | year = 1996 | pmid = 8617505 | doi = 10.1006/geno.1996.0177 | doi-access = free }}
• {{cite journal | vauthors = Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ|author-link4=D. James Surmeier | title = CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins | journal = Mol. Cell. Neurosci. | volume = 11 | issue = 3 | pages = 161–72 | year = 1998 | pmid = 9647694 | doi = 10.1006/mcne.1998.0679 |s2cid=36534759 }}
• {{cite journal | vauthors = Vaccaro P, Brannetti B, Montecchi-Palazzi L, Philipp S, Helmer Citterich M, Cesareni G, Dente L | title = Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster | journal = J. Biol. Chem. | volume = 276 | issue = 45 | pages = 42122–30 | year = 2001 | pmid = 11509564 | doi = 10.1074/jbc.M104208200 | doi-access = free }}
• {{cite journal | vauthors = Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E | title = The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons | journal = J. Biol. Chem. | volume = 277 | issue = 19 | pages = 16655–61 | year = 2002 | pmid = 11872753 | doi = 10.1074/jbc.M201087200 | doi-access = free }}
• {{cite journal | vauthors = Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B | title = The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost | journal = J. Cell Biol. | volume = 157 | issue = 1 | pages = 161–72 | year = 2002 | pmid = 11927608 | pmc = 2173254 | doi = 10.1083/jcb.200109010 }}
• {{cite journal | vauthors = Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A | title = hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells | journal = J. Biol. Chem. | volume = 277 | issue = 28 | pages = 25408–15 | year = 2002 | pmid = 11964389 | doi = 10.1074/jbc.M202196200 | doi-access = free }}
• {{cite journal | vauthors = Roh MH, Liu CJ, Laurinec S, Margolis B | title = The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions | journal = J. Biol. Chem. | volume = 277 | issue = 30 | pages = 27501–9 | year = 2002 | pmid = 12021270 | doi = 10.1074/jbc.M201177200 | doi-access = free }}
• {{cite journal | vauthors = Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B | title = Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1) | journal = Gene | volume = 302 | issue = 1–2 | pages = 21–9 | year = 2003 | pmid = 12527193 | doi = 10.1016/S0378111902010843 }}
• {{cite journal | vauthors = Roh MH, Fan S, Liu CJ, Margolis B | title = The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells | journal = J. Cell Sci. | volume = 116 | issue = Pt 14 | pages = 2895–906 | year = 2004 | pmid = 12771187 | doi = 10.1242/jcs.00500 | s2cid = 4482921 | doi-access = }}
• {{cite journal | vauthors = Li Y, Karnak D, Demeler B, Margolis B, Lavie A | title = Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes | journal = EMBO J. | volume = 23 | issue = 14 | pages = 2723–33 | year = 2005 | pmid = 15241471 | pmc = 514954 | doi = 10.1038/sj.emboj.7600294 }}
• {{cite journal | vauthors = Michel D, Arsanto JP, Massey-Harroche D, Béclin C, Wijnholds J, Le Bivic A | title = PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells | journal = J. Cell Sci. | volume = 118 | issue = Pt 17 | pages = 4049–57 | year = 2005 | pmid = 16129888 | doi = 10.1242/jcs.02528 | s2cid = 19826254 | doi-access = }}
• {{cite journal | vauthors = Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G | title = Uncovering Quantitative Protein Interaction Networks for Mouse PDZ Domains using Protein Microarrays | journal = J. Am. Chem. Soc. | volume = 128 | issue = 17 | pages = 5913–22 | year = 2007 | pmid = 16637659 | pmc = 2533859 | doi = 10.1021/ja060943h }}
• {{cite journal | vauthors = Wells CD, Fawcett JP, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T | title = A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells | journal = Cell | volume = 125 | issue = 3 | pages = 535–48 | year = 2006 | pmid = 16678097 | doi = 10.1016/j.cell.2006.02.045 | s2cid = 18651810 | doi-access = free }}

{{refend}}

• {{UCSC genome browser|INADL}}
• {{UCSC gene details|INADL}}
• {{PDBe-KB2|Q8NI35|InaD-like protein}}

{{PDB Gallery|geneid=10207}}

{{gene-1-stub}}