Insulin receptor substrate
Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells.
IRS-1, for example, is an IRS protein that contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin receptor contains a NPXY motif. The PTB-domain binds the NPXY sequence. Thus, the insulin receptor binds IRS.
Genes
- {{Gene|IRS1}} (see also Insulin receptor substrate 1)
- {{Gene|IRS2}} (see also Insulin receptor substrate 2)
- {{Gene|IRS3P}} - a pseudogene
- {{Gene|IRS4}}
References
- {{cite journal |vauthors=van der Geer P, Wiley S, Pawson T |title=Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site |journal=Oncogene |volume=18 |issue=20 |pages=3071–5 |year=1999 |pmid=10340378 |doi=10.1038/sj.onc.1202879|doi-access=free }}