Integrin alpha 2
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{{Short description|Mammalian protein found in Homo sapiens}}
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Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene.
The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface-mediated signalling.{{cite web | title = Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3673}}
Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells.{{cite journal | vauthors = Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A, Trentini F, Di Serio C, Bacchetta R, Andreani M, Brockmann L, Gregori S, Flavell RA, Roncarolo MG | title = Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells | journal = Nature Medicine | volume = 19 | issue = 6 | pages = 739–746 | date = June 2013 | pmid = 23624599 | doi = 10.1038/nm.3179 | s2cid = 21305032 }}
The DX5 monoclonal antibody recognizes mouse CD49b.{{cite journal | vauthors = Arase H, Saito T, Phillips JH, Lanier LL | title = Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2) | journal = Journal of Immunology | volume = 167 | issue = 3 | pages = 1141–1144 | date = August 2001 | pmid = 11466327 | doi = 10.4049/jimmunol.167.3.1141 | doi-access = free }}
Interactions
CD49b has been shown to interact with MMP1.{{cite journal | vauthors = Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA | title = Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction | journal = The Journal of Biological Chemistry | volume = 276 | issue = 31 | pages = 29375–29381 | date = August 2001 | pmid = 11359774 | doi = 10.1074/jbc.M102217200 | doi-access = free }}{{cite journal | vauthors = Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC | title = Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen | journal = The Journal of Biological Chemistry | volume = 276 | issue = 31 | pages = 29368–29374 | date = August 2001 | pmid = 11359786 | doi = 10.1074/jbc.M104179200 | doi-access = free }}
References
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Further reading
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- {{cite journal | vauthors = Moroi M, Jung SM | title = Platelet receptors for collagen | journal = Thrombosis and Haemostasis | volume = 78 | issue = 1 | pages = 439–444 | date = July 1997 | pmid = 9198193 | doi = 10.1055/s-0038-1657566 | s2cid = 8121197 }}
- {{cite journal | vauthors = Takada Y, Kamata T, Irie A, Puzon-McLaughlin W, Zhang XP | title = Structural basis of integrin-mediated signal transduction | journal = Matrix Biology | volume = 16 | issue = 4 | pages = 143–151 | date = October 1997 | pmid = 9402003 | doi = 10.1016/S0945-053X(97)90002-0 }}
- {{cite journal | vauthors = Dickeson SK, Santoro SA | title = Ligand recognition by the I domain-containing integrins | journal = Cellular and Molecular Life Sciences | volume = 54 | issue = 6 | pages = 556–566 | date = June 1998 | pmid = 9676575 | pmc = 11147323 | doi = 10.1007/s000180050184 | s2cid = 9775686 }}
- {{cite journal | vauthors = Porter JC, Hogg N | title = Integrins take partners: cross-talk between integrins and other membrane receptors | journal = Trends in Cell Biology | volume = 8 | issue = 10 | pages = 390–396 | date = October 1998 | pmid = 9789327 | doi = 10.1016/S0962-8924(98)01344-0 }}
- {{cite journal | vauthors = Plenz GA, Deng MC, Robenek H, Völker W | title = Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis | journal = Atherosclerosis | volume = 166 | issue = 1 | pages = 1–11 | date = January 2003 | pmid = 12482545 | doi = 10.1016/S0021-9150(01)00766-3 }}
- {{cite journal | vauthors = Charakida M, Tousoulis D, Stefanadis C, Toutouzas P | title = The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease | journal = Italian Heart Journal | volume = 4 | issue = 1 | pages = 17–22 | date = January 2003 | pmid = 12690916 }}
- {{cite journal | vauthors = Tsantes AE, Nikolopoulos GK, Bagos PG, Vaiopoulos G, Travlou A | title = Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: a meta-analysis | journal = International Journal of Cardiology | volume = 118 | issue = 2 | pages = 189–196 | date = May 2007 | pmid = 17023078 | doi = 10.1016/j.ijcard.2006.06.047 }}
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External links
- {{MeshName|CD49b+antigen}}
- [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P17301 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Integrin alpha 2
- {{cite web | url = http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=3673 | archive-url = https://archive.today/20130414104845/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=3673 | archive-date=2013-04-14 | title = ITGA2 | work = Cell Migration Gateway }}
- {{UCSC gene info|ITGA2}}
{{PDB Gallery|geneid=3673}}
{{Clusters of differentiation}}
{{Integrins}}
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