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Integrin alpha 2b

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{{Short description|Mammalian protein found in Homo sapiens}}

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Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered.{{cite journal | vauthors = Šimčíková D, Heneberg P | title = Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 18577 | date = December 2019 | pmid = 31819097 | pmc = 6901466 | doi = 10.1038/s41598-019-54976-4| bibcode = 2019NatSR...918577S }} In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.{{cite web | title = Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3674}}

Interactions

ITGA2B has been shown to interact with AUP1{{cite journal |last=Kato |first=Atsushi |author2=Kawamata Norihiko |author3=Tamayose Kenji |author4=Egashira Motoki |author5=Miura Rika |author6=Fujimura Tsutomu |author7=Murayama Kimie |author8=Oshimi Kazuo |date=Aug 2002 |title=Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3 |journal=J. Biol. Chem. |volume=277 |issue=32 |pages=28934–41 |location = United States| issn = 0021-9258| pmid = 12042322 |doi = 10.1074/jbc.M204340200 |doi-access=free }} and CLNS1A.{{cite journal |last=Larkin |first=Deirdre |author2=Murphy Derek |author3=Reilly Dermot F |author4=Cahill Martha |author5=Sattler Ellen |author6=Harriott Pat |author7=Cahill Dolores J |author8=Moran Niamh |date=Jun 2004 |title=ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation |journal=J. Biol. Chem. |volume=279 |issue=26 |pages=27286–93 |location = United States| issn = 0021-9258| pmid = 15075326 |doi = 10.1074/jbc.M402159200 |doi-access=free }}

See also

References

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Further reading

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  • {{cite journal | author=Bray PF |title=Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization. |journal=Thromb. Haemost. |volume=72 |issue= 4 |pages= 492–502 |year= 1995 |pmid= 7878622 }}
  • {{cite journal |vauthors=Naik UP, Parise LV |title=Structure and function of platelet alpha IIb beta 3. |journal=Curr. Opin. Hematol. |volume=4 |issue= 5 |pages= 317–22 |year= 1997 |pmid= 9288464 |doi= 10.1097/00062752-199704050-00004}}
  • {{cite journal |vauthors=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390–6 |year= 1999 |pmid= 9789327 |doi=10.1016/S0962-8924(98)01344-0 }}
  • {{cite journal | author=Lincoff AM |title=Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization. |journal=Am. J. Cardiol. |volume=82 |issue= 8B |pages= 36P–42P |year= 1998 |pmid= 9809890 |doi=10.1016/S0002-9149(98)00662-6 }}
  • {{cite journal | author=Bennett JS |title=Platelet-fibrinogen interactions. |journal=Ann. N. Y. Acad. Sci. |volume=936 |pages= 340–54 |year= 2001 |issue=1 |pmid= 11460491 |doi=10.1111/j.1749-6632.2001.tb03521.x |bibcode=2001NYASA.936..340B |s2cid=25431334 }}
  • {{cite journal |vauthors=Plow EF, Cierniewski CS, Xiao Z, etal |title=AlphaIIbbeta3 and its antagonism at the new millennium. |journal=Thromb. Haemost. |volume=86 |issue= 1 |pages= 34–40 |year= 2002 |pmid= 11487023 |doi= 10.1055/s-0037-1616198|s2cid=74389210 }}
  • {{cite journal |vauthors=Quinn MJ, Byzova TV, Qin J, etal |title=Integrin alphaIIbbeta3 and its antagonism. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 6 |pages= 945–52 |year= 2004 |pmid= 12637342 |doi= 10.1161/01.ATV.0000066686.46338.F1 |doi-access= free }}
  • {{cite journal | author=Fullard JF |title=The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis. |journal=Curr. Pharm. Des. |volume=10 |issue= 14 |pages= 1567–76 |year= 2004 |pmid= 15134555 |doi=10.2174/1381612043384682 }}
  • {{cite journal |vauthors=Watson SP, Auger JM, McCarty OJ, Pearce AC |title=GPVI and integrin alphaIIb beta3 signaling in platelets. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1752–62 |year= 2005 |pmid= 16102042 |doi= 10.1111/j.1538-7836.2005.01429.x |s2cid=42666713 |doi-access=free }}
  • {{cite journal | author=Bennett JS |title=Structure and function of the platelet integrin alphaIIbbeta3. |journal=J. Clin. Invest. |volume=115 |issue= 12 |pages= 3363–9 |year= 2006 |pmid= 16322781 |doi= 10.1172/JCI26989 | pmc=1297263 }}
  • {{cite journal |vauthors=Ma YQ, Qin J, Plow EF |title=Platelet integrin alpha(IIb)beta(3): activation mechanisms. |journal=J. Thromb. Haemost. |volume=5 |issue= 7 |pages= 1345–52 |year= 2007 |pmid= 17635696 |doi= 10.1111/j.1538-7836.2007.02537.x |s2cid=12983526 |doi-access=free }}

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External links

  • {{MeshName|CD41+Antigen}}
  • {{PDBe-KB2|P08514|Human Integrin alpha-IIb}}

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{{Clusters of differentiation}}

{{Coagulation}}

Category:Clusters of differentiation

Category:Integrins

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