Interferon gamma 5' UTR regulatory element

{{Infobox rfam

| Name = Interferon gamma 5' UTR regulatory element

| image = RF00259.jpg

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| caption = Predicted secondary structure and sequence conservation of IFN_gamma

| Symbol = IFN_gamma

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| Rfam = RF00259

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| RNA_type = Cis-reg

| Tax_domain = Eukaryota

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| SO = {{SO|0000204}}

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Interferon gamma 5' UTR regulatory elements are a family of regulatory RNAs. This family represents a pseudoknot containing stem-loop structure found in the 5' UTR of interferon-gamma mRNA. This structure is thought to be involved in translational regulation and the pseudoknot has been found to activate protein kinase R (PKR) which is known to be a translational inhibitor. Mutations in the pseudoknot structure have been found to reduce PKR activation and increase the translation of interferon-gamma.{{cite journal | vauthors = Ben-Asouli Y, Banai Y, Pel-Or Y, Shir A, Kaempfer R | title = Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR | journal = Cell | volume = 108 | issue = 2 | pages = 221–232 | date = January 2002 | pmid = 11832212 | doi = 10.1016/S0092-8674(02)00616-5 | doi-access = free }}