Intergenic lcrF RNA thermometer

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{{Infobox rfam

| Name = LcrF intergenic thermometer

| image = RF02704.svg

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| caption = Predicted secondary structure and sequence conservation of LcrF intergenic thermometer

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| Rfam = RF02704

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| Tax_domain = Bacteria

| GO = {{GO|0045975}},{{GO|0009266}}

| SO = {{SO|0005836}}

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RNA thermometers regulate gene expression in response to temperature allowing pathogens like Yersinia to switch on silent genes after entering the host organism. Usually, RNA thermometers are located in the 5'UTR, but an intergenic RNA thermometer was found in Yersinia pseudotuberculosis. The LcrF RNA thermometer together with the thermo-labile YmoA protein activates synthesis of the most crucial virulence activator [https://www.uniprot.org/uniprot/P28808 LcrF] (VirF). The RNA thermosensor sequence is 100% identical in all human pathogenic Yersinia species.{{cite journal | vauthors = Böhme K, Steinmann R, Kortmann J, Seekircher S, Heroven AK, Berger E, Pisano F, Thiermann T, Wolf-Watz H, Narberhaus F, Dersch P | title = Concerted actions of a thermo-labile regulator and a unique intergenic RNA thermosensor control Yersinia virulence | journal = PLOS Pathogens | volume = 8 | issue = 2 | pages = e1002518 | date = February 2012 | pmid = 22359501 | pmc = 3280987 | doi = 10.1371/journal.ppat.1002518 | doi-access = free }}{{cite journal | vauthors = Schwiesow L, Lam H, Dersch P, Auerbuch V | title = Yersinia Type III Secretion System Master Regulator LcrF | journal = Journal of Bacteriology | volume = 198 | issue = 4 | pages = 604–614 | date = December 2015 | pmid = 26644429 | pmc = 4751813 | doi = 10.1128/JB.00686-15 }}