Interleukin-7 receptor-α

{{Short description|Protein-coding gene in the species Homo sapiens}}

Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene.{{cite web | title = Entrez Gene: IL7R interleukin 7 receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3575}}{{cite journal |vauthors=Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE | title = Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily | journal = Cell | volume = 60 | issue = 6 | pages = 941–51 |date=March 1990 | pmid = 2317865 | doi =10.1016/0092-8674(90)90342-C | s2cid = 45181020 }}

IL7R-α is a type I cytokine receptor and is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors.

References

{{cite journal |vauthors=Akashi K, Kondo M, Weissman IL |title=Role of interleukin-7 in T-cell development from hematopoietic stem cells. |journal=Immunol. Rev. |volume=165 |pages= 13–28 |year= 1999 |pmid= 9850848 |doi=10.1111/j.1600-065X.1998.tb01226.x |s2cid=45365828 }}
{{cite journal | author=Appasamy PM |title=Biological and clinical implications of interleukin-7 and lymphopoiesis. |journal=Cytokines Cell. Mol. Ther. |volume=5 |issue= 1 |pages= 25–39 |year= 1999 |pmid= 10390077 }}
{{cite journal |vauthors=Al-Rawi MA, Mansel RE, Jiang WG |title=Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours. |journal=Histol. Histopathol. |volume=18 |issue= 3 |pages= 911–23 |year= 2004 |pmid= 12792903 }}
{{cite journal | author=Banham AH |title=Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells. |journal=Trends Immunol. |volume=27 |issue= 12 |pages= 541–4 |year= 2007 |pmid= 17045841 |doi= 10.1016/j.it.2006.10.002 }}
{{cite journal |vauthors=Nishii K, Kita K, Miwa H, etal |title=c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid-associated antigen CD13. |journal=Leukemia |volume=6 |issue= 7 |pages= 662–8 |year= 1992 |pmid= 1378163 }}
{{cite journal |vauthors=Lynch M, Baker E, Park LS, etal |title=The interleukin-7 receptor gene is at 5p13. |journal=Hum. Genet. |volume=89 |issue= 5 |pages= 566–8 |year= 1992 |pmid= 1634235 |doi=10.1007/BF00219186 |s2cid=8151834 }}
{{cite journal |vauthors=Pleiman CM, Gimpel SD, Park LS, etal |title=Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter. |journal=Mol. Cell. Biol. |volume=11 |issue= 6 |pages= 3052–9 |year= 1991 |pmid= 2038316 |doi= 10.1128/MCB.11.6.3052| pmc=360143 }}
{{cite journal |vauthors=Seckinger P, Fougereau M |title=Activation of src family kinases in human pre-B cells by IL-7. |journal=J. Immunol. |volume=153 |issue= 1 |pages= 97–109 |year= 1994 |doi=10.4049/jimmunol.153.1.97 |pmid= 7515933 }}
{{cite journal |vauthors=van der Plas DC, Smiers F, Pouwels K, etal |title=Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain. |journal=Leukemia |volume=10 |issue= 8 |pages= 1317–25 |year= 1996 |pmid= 8709637 }}
{{cite journal |vauthors=Maraskovsky E, O'Reilly LA, Teepe M, etal |title=Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice. |journal=Cell |volume=89 |issue= 7 |pages= 1011–9 |year= 1997 |pmid= 9215624 |doi=10.1016/S0092-8674(00)80289-5 |s2cid=16192745 |doi-access=free }}
{{cite journal |vauthors=Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR |title=Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. |journal=Nature |volume=391 |issue= 6670 |pages= 904–7 |year= 1998 |pmid= 9495344 |doi= 10.1038/36122 |bibcode=1998Natur.391..904C |s2cid=205024726 }}
{{cite journal |vauthors=Puel A, Ziegler SF, Buckley RH, Leonard WJ |title=Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. |journal=Nat. Genet. |volume=20 |issue= 4 |pages= 394–7 |year= 1998 |pmid= 9843216 |doi= 10.1038/3877 |s2cid=25873360 }}
{{cite journal |vauthors=Ye SK, Maki K, Kitamura T, etal |title=Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor. |journal=Immunity |volume=11 |issue= 2 |pages= 213–23 |year= 1999 |pmid= 10485656 |doi=10.1016/S1074-7613(00)80096-5 |doi-access=free }}
{{cite journal |vauthors=Benbernou N, Muegge K, Durum SK |title=Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 7060–5 |year= 2000 |pmid= 10702271 |doi=10.1074/jbc.275.10.7060 |doi-access=free }}
{{cite journal |vauthors=Roifman CM, Zhang J, Chitayat D, Sharfe N |title=A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency. |journal=Blood |volume=96 |issue= 8 |pages= 2803–7 |year= 2000 |pmid= 11023514 |doi= 10.1182/blood.V96.8.2803}}
{{cite journal |vauthors=Reche PA, Soumelis V, Gorman DM, etal |title=Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. |journal=J. Immunol. |volume=167 |issue= 1 |pages= 336–43 |year= 2001 |pmid= 11418668 |doi= 10.4049/jimmunol.167.1.336|doi-access=free |url=https://docta.ucm.es/bitstreams/d6b4babc-116c-4eb2-8300-ea5f088358c1/download }}

External links

{{MeshName|IL7R+protein,+human}}
{{PDBe-KB2|P16871|Human Interleukin-7 receptor subunit alpha}}
{{PDBe-KB2|P16872|Mouse Interleukin-7 receptor subunit alpha}}

Category:Type I cytokine receptors

Category:Clusters of differentiation

Interleukin-7 receptor-α

References

Further reading

External links