Interolog
An interolog is a conserved interaction between a pair of proteins which have interacting homologs in another organism. The term was introduced in a 2000 paper by Walhout et al.{{Cite journal | last1 = Walhout | first1 = A. J. | last2 = Sordella | first2 = R. | last3 = Lu | first3 = X. | last4 = Hartley | first4 = J. L. | last5 = Temple | first5 = G. F. | last6 = Brasch | first6 = M. A. | last7 = Thierry-Mieg | first7 = N. | last8 = Vidal | first8 = M. | doi = 10.1126/science.287.5450.116 | title = Protein Interaction Mapping in C. Elegans Using Proteins Involved in Vulval Development | journal = Science | volume = 287 | issue = 5450 | pages = 116–122 | year = 2000 | pmid = 10615043| bibcode = 2000Sci...287..116W }}{{Cite journal | doi=10.1101/gr.1774904| pmid=15173116| pmc=419789| title=Annotation Transfer Between Genomes: Protein-Protein Interologs and Protein-DNA Regulogs| journal=Genome Research| volume=14| issue=6| pages=1107–1118| year=2004| last1=Yu| first1=H.| last2=Luscombe| first2=N. M.| last3=Lu| first3=H. X.| last4=Zhu| first4=X.| last5=Xia| first5=Y.| last6=Han| first6=J. D.| last7=Bertin| first7=N.| last8=Chung| first8=S.| last9=Vidal| first9=M.| last10=Gerstein| first10=M.}}
Example
File:HypotheticalInterologExample.png
Suppose that A and B are two different interacting human proteins, and A' and B' are two different interacting dog proteins. Then the interaction between A and B is an interolog of the interaction between A' and B' if the following conditions all hold:
- A is a homolog of A'. (Protein homologs have similar amino acid sequences and derive from a common ancestral sequence).
- B is a homolog of B'.
- A and B interact.
- A' and B' interact.
Thus, interologs are homologous pairs of protein interactions across different organisms.
See also
References
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{{refbegin}}
- {{Cite journal
| last1 = Yu | first1 = H.
| last2 = Luscombe | first2 = N. M.
| last3 = Lu | first3 = H. X.
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| last6 = Han | first6 = J. D.
| last7 = Bertin | first7 = N.
| last8 = Chung | first8 = S.
| last9 = Vidal | first9 = M.
| last10 = Gerstein | first10 = M.
| title = Annotation Transfer Between Genomes: Protein-Protein Interologs and Protein-DNA Regulogs
| doi = 10.1101/gr.1774904
| journal = Genome Research
| volume = 14
| issue = 6
| pages = 1107–1118
| year = 2004
| pmid = 15173116
| pmc =419789
}}
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| last1 = Kemmer | first1 = D.
| last2 = Huang | first2 = Y.
| last3 = Shah | first3 = S. P.
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| last8 = Xu | first8 = T.
| last9 = Wasserman | first9 = W. W.
| last10 = Ouellette | first10 = B. F.
| title = Ulysses - an application for the projection of molecular interactions across species
| journal = Genome Biology
| volume = 6
| issue = 12
| pages = R106
| doi = 10.1186/gb-2005-6-12-r106
| year = 2005
| pmid = 16356269
| pmc =1414088
| doi-access = free
}}
- {{Cite journal
| last1 = Wiles | first1 = A. M.
| last2 = Doderer | first2 = M.
| last3 = Ruan | first3 = J.
| last4 = Gu | first4 = T. T.
| last5 = Ravi | first5 = D.
| last6 = Blackman | first6 = B.
| last7 = Bishop | first7 = A. J.
| title = Building and analyzing protein interactome networks by cross-species comparisons
| doi = 10.1186/1752-0509-4-36
| journal = BMC Systems Biology
| volume = 4
| pages = 36
| year = 2010
| pmid = 20353594
| pmc =2859380
| doi-access = free
}}
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External links
- [http://interactome.org Interactome.org] {{Webarchive|url=https://web.archive.org/web/20080820063335/http://interactome.org/ |date=2008-08-20 }}: Interactome portal site.
- {{usurped|1=[https://web.archive.org/web/20080706140930/http://interactomics.org/ Interactomics.org]}}: Interactomics portal site.
- [http://www.interologfinder.org]: Cross-species interaction prediction site.
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