Intracameral injection

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| name = Intracameral injection

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| image = Three Main Layers of the Eye.png

| caption = Intravitreal administration delivers substances directly into the anterior chamber of eyeball.

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| specialty = ophthalmology

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An intracameral injection is usually of an antibiotic into the anterior chamber of the eyeball to prevent endophthalmitis caused by an infection of the eye that can occur after cataract surgery. The Food and Drug Administration (FDA) has not approved antibiotics for this use and it is considered 'off-label'. Concerns about this procedure contributing to increasing numbers of antibiotic resistant bacteria have been expressed.{{cite web | vauthors = Kent C | title = Antibiotics & cataract surgery: new frontiers. | work = Review of Ophthalmology. |url=https://www.reviewofophthalmology.com/article/antibiotics--cataract-surgery-new-frontiers |publisher=|access-date=3 April 2017}}

In the UK, Aprokam cefuroxime has been approved for use in intracameral injections.{{cite web|url=https://www.medicines.org.uk/emc/medicine/27397|title=Aprokam cefuroxime 50mg powder for solution for injection - Summary of Product Characteristics (SPC) - (eMC)|publisher=|access-date=3 April 2017}} Intracameral injection of recombinant tissue plasminogen activator (r-TPA) has been found to be effective in treating the development of fibrin intraocularly after the development of endophthalmitis.{{cite journal | vauthors = Wu TT, Wang HH | title = Intracameral recombinant tissue plasminogen activator for the treatment of severe fibrin reaction in endophthalmitis | journal = Eye | volume = 23 | issue = 1 | pages = 101–107 | date = January 2009 | pmid = 17901882 | doi = 10.1038/sj.eye.6702984 | doi-access = free }}