Intraductal papilloma

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| image = Intraductal papilloma histopathology (3) p63.JPG

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| caption = Histopathology of intraductal papilloma of the breast by excisional biopsy. Immunostaining for p63 protein.

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Intraductal papillomas of the breast are benign lesions with an incidence of approximately 2-3% in humans.{{cite journal | vauthors = Cilotti A, Bagnolesi P, Napoli V, Lencioni R, Bartolozzi C | title = [Solitary intraductal papilloma of the breast. An echographic study of 12 cases] | language = it | journal = La Radiologia Medica | volume = 82 | issue = 5 | pages = 617–20 |date=November 1991 | pmid = 1780459 }} They result from abnormal proliferation of the epithelial cells lining the breast ducts.{{cite journal | vauthors = Li A, Kirk L | title = Intraductal Papilloma. | journal = StatPearls | pages = Internet |date=January 2020 | pmid = 30137824 | url = https://www.ncbi.nlm.nih.gov/books/NBK519539/ }}

Two types of intraductal papillomas are generally distinguished. The central type develops near the nipple. They are usually solitary and often arise in the years nearing menopause. On the other hand, the peripheral type are often multiple papillomas arising at the peripheral ducts, and are usually found in younger women. The peripheral type are associated with a higher risk of malignancy.{{cite journal|last=Tarallo|first=V|author2=Canepari, E |author3=Bortolotto, C |title=Intraductal papilloma of the breast: A case report |journal=Journal of Ultrasound|date=June 2012|volume=15|issue=2|pages=99–101|pmid=23396758|doi=10.1016/j.jus.2012.03.002 |pmc=3558092}}

They are the most common cause of bloody nipple discharge in women age 20-40 and generally do not show up on mammography due to their small size. They may be detectable on ultrasound. A galactogram is the most definitive test but is somewhat invasive.

The masses are often too small to be palpated or felt. A galactogram is therefore necessary to diagnose the type of lesion.

Excision is sometimes performed.{{cite journal |vauthors=Ahmadiyeh N, Stoleru MA, Raza S, Lester SC, Golshan M |title=Management of intraductal papillomas of the breast: an analysis of 129 cases and their outcome |journal=Annals of Surgical Oncology |volume=16 |issue=8 |pages=2264–9 |date=August 2009 |pmid=19484312 |doi=10.1245/s10434-009-0534-1 |s2cid=21938897 }} Microdochectomy/microdochotomy (removal of a breast duct) is the treatment of choice.