Intraneural perineurioma
An intraneural perineurioma is a rare benign tumor within the sheath of a single nerve that grows but typically does not recur or metastasize. These lesions are only composed of perineurial cells, cloned from a single cell. They are distinct from schwannoma and neurofibroma.
Intraneural perineurioma is a neoplastic proliferation of perineurial cells with unique immunohistochemistry and ultrastructural features, and it is distinct from other onion bulb Schwann cell-derived entities. Despite harboring molecular abnormalities of the long arm of chromosome 22, intraneural perineurioma has not been associated with neurofibromatosis.{{cite journal |journal=Archives of Pathology & Laboratory Medicine |year=2007 |volume=131 |issue=9 |pages=1382–92 |title= Intraneural perineurioma: a systematic review with illustrative cases|author1=Boyanton BL Jr |author2=Jones JK |author3=Shenaq SM |author4=Hicks MJ |author5=Bhattacharjee MB |pmid=17824794 |doi=10.5858/2007-131-1382-IPASRW}}
Due to the involvement of one or more nerve fascicles, intraneural perineuriomas are distinguished by a localized, solitary expansion of peripheral nerves. These tumors develop slowly or stay stable over time.{{cite journal | pmid=19567701 | year=2009 | last1=Mauermann | first1=M. L. | last2=Amrami | first2=K. K. | last3=Kuntz | first3=N. L. | last4=Spinner | first4=R. J. | last5=Dyck | first5=P. J. | last6=Bosch | first6=E. P. | last7=Engelstad | first7=J. | last8=Felmlee | first8=J. P. | last9=Dyck | first9=P. J. | title=Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youth | journal=Brain | volume=132 | issue=Pt 8 | pages=2265–2276 | doi=10.1093/brain/awp169 | pmc=2724918 }}
References
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Further reading
- {{cite journal |journal=Archives of Pathology & Laboratory Medicine |year=2007 |volume=131 |issue=4 |pages=625–36 |title=Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm |vauthors=Macarenco RS, Ellinger F, Oliveira AM |pmid=17425397 |doi=10.5858/2007-131-625-PADAUP}}
- {{cite journal |journal=Head & Neck |year=2009 |volume=31 |issue=6 |pages=833–7 |title=Intraneural reticular perineurioma of the hypoglossal nerve. |vauthors=Kum YS, Kim JK, Cho CH, Kim HK |pmid=18972430 |doi=10.1002/hed.20965 |s2cid=19616068 }}
- {{cite journal |journal=Arch Plast Surg |year=2014 |volume=41 |issue=3 |pages=296–9 |title=Surgical removal of intraneural perineurioma arising in the brachial plexus using an interfascicular dissection technique |vauthors=Chung JH, Jeong SH, Dhong ES, Han SK |pmid=24883285 |pmc=4037780 |doi=10.5999/aps.2014.41.3.296 }}
- {{cite journal |title=Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22|vauthors=Emory TS, Scheithauer BW, Hirose T, Wood M, Onofrio BM, Jenkins RB |journal=Am J Clin Pathol |year=1995 |volume=103 |issue=6 |pages=696–704 |pmid=7785653 |doi=10.1093/ajcp/103.6.696}}