Invasive urothelial carcinoma

{{Infobox medical condition (new)

| name = Invasive urethelia carcinoma

| synonyms =

| image = File:Invasive urothelial carcinoma.png

| caption = Immunoperoxidase staining of ZIP8 in high grade urothelial carcinoma.A &B. Noninvasive urothelial carcinoma showing weak staining of ZIP8 (+). Asterisks (*) indicate stromal tissue which is negative for ZIP8. C. Noninvasive urothelial carcinoma with focal moderate staining of ZIP8 (+). Asterisks (*) indicate stromal tissue which is negative for ZIP8. D. Invasive urothelial carcinoma with negative staining of ZIP8 (−). Few smooth muscle fibers between the invasive tumor nests are weakly positive for ZIP8 (*). E. Invasive urothelial carcinoma with focal weak staining of ZIP8 (+). Asterisks (*) indicate stromal tissue which is negative for ZIP8. F. Invasive urothelial carcinoma with weak staining of ZIP8 (+). A few spindled shaped stromal cells are also weakly positive for ZIP8 (*). G. Anaplastic urothelial carcinoma showing moderate staining for ZIP8 (+). Asterisks (*) indicate stromal tissue which is negative for ZIP8. H. Invasive urothelial carcinoma with moderate to strong staining of ZIP8 (*). A few spindled shaped stromal cells are weakly positive for ZIP8 (*). I. Poorly differentiated urothelial carcinoma with strong staining for ZIP8 (+). Asterisks (*) indicate stromal tissue which is negative for ZIP8.

| pronounce =

| field = Oncology

| symptoms =

| complications =

| onset =

| duration =

| types =

| causes =

| risks =

| diagnosis =

| differential =

| prevention =

| treatment =

| medication =

| prognosis =

| frequency =

| deaths =

}}

Invasive urothelial carcinoma is a type of transitional cell carcinoma. It is a type of cancer that develops in the urinary system: the kidney, urinary bladder, and accessory organs. Transitional cell carcinoma is the most common type of bladder cancer and cancer of the ureter, urethra, renal pelvis, the ureters, the bladder, and parts of the urethra and urachus.Andersson, 2011: [https://books.google.com/books?id=jnfQ5VbxJ_AC&pg=PA134 p. 134]{{cite journal|last1=Amornpan|first1=Ajjimaporn|last2=Botsford|first2=Tom|last3=Garrett|first3=Scott H|last4=Sens|first4=Mary Ann|last5=Zhou|first5=Xu Dong|last6=Dunlevy|first6=Jane R|last7=Sens|first7=Donald A|last8=Somji|first8=Seema|date=2012-07-04|title=ZIP8 expression in human proximal tubule cells, human urothelial cells transformed by Cd+2 and As+3 and in specimens of normal human urothelium and urothelial cancer|journal=Cancer Cell Int.|volume=12|issue=16|page=16|doi=10.1186/1475-2867-12-16|pmid=22550998|pmc=3390278 |doi-access=free }} It originates from tissue lining the inner surface of these hollow organs - transitional epithelium.{{DorlandsDict|two/000017251|transitional cell carcinoma}}{{cite web|url=http://www.medterms.com/script/main/art.asp?articlekey=20677|title=Definition of Carcinoma|url-status=dead|access-date=2017-06-12|archive-date=2012-10-10|archive-url=https://web.archive.org/web/20121010214950/http://www.medterms.com/script/main/art.asp?articlekey=20677}} The invading tumors can extend from the kidney collecting system to the bladder.Selvaraj V, Govindarajan P, Deepak M, Sivaraj M. "The creeping tumor:" An unusual presentation of upper urinary tract malignancy.

Indian J Urol 2014;30:454-5.

Carcinoma (from the Greek karkinos, or "crab", and -oma, "growth") is a type of cancer.{{cite book|last1=Lemoine|first1=Nigel Kirkham, Nicholas R.|title=Progress in pathology.|date=2001|publisher=Greenwich Medical Media|location=London|isbn=9781841100500|page=52|url=https://books.google.com/books?id=xiHcyr-BHeQC&pg=PT61}} A carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that generally arises from cells originating in the endodermal or ectodermal germ layer during embryogenesis.