Isabelle Mansuy

Mansuy studied molecular biology and biotechnology at the University Louis Pasteur and the École Supérieure de Biotechnologie de Strasbourg.{{Cite web|url=https://esbs.unistra.fr/ecole/les-anciens-alumni/les-ingenieurs-en-biotechnologie-de-lesbs/|title=Les Ingénieurs en Biotechnologie de l'ESBS – ESBS – Université de Strasbourg|website=esbs.unistra.fr|access-date=2020-04-03}} Mansuy went on to earn a PhD at the Friedrich Miescher Institute in Basel{{Cite web|url=https://fmi.ch/|title=FMI – Friedrich Miescher Institute for Biomedical Research – Denis Monard|last=FMI|website=fmi.ch|access-date=2020-04-03}} then a postdoc at Columbia University, where she gained expertise in neurobiology and in the design and use of transgenic mouse models. She established a lab as assistant professor at ETH Zürich at the end of 1998 and a few years later became professor in neuroepigenetics at the University of Zürich and ETH Zürich.{{Cite web|url=https://www.hifo.uzh.ch/en/research/mansuy.html|title=Laboratory of Neuroepigenetics|website=www.hifo.uzh.ch|language=en|access-date=2020-04-02}}

Mansuy initially worked on the molecular mechanisms of memory using mouse models.{{Cite news|date=August 29, 2002|title=How the brain forgets|language=en-GB|url=http://news.bbc.co.uk/2/hi/health/2222871.stm|access-date=2020-07-15}} Her team revealed the specific molecules that allow the adult brain to forget through constraining memory formation and storage. It identified protein phosphatase 1 (PP1) and calcineurin as such molecular suppressors and demonstrated that these molecules need to be inhibited through training to relieve their suppressing action on neuronal activity necessary for memorisation. Her team was also able to demonstrate the detrimental effects of the excess of these molecules in the diseased and aged brain, highlighting their link to memory deficits and cognitive decline in aging. Another important finding was that PP1 is a key epigenetic regulator in neurons that controls the post-translational modification of histones and therefore genome activity. The role of such an enzyme in epigenetic regulation in relation to cognitive processes was not known before, these findings participated to found the new field of neuroepigenetics that emerged in late 2000, and opened unexpected therapeutic perspectives linking the epigenome to memory diseases.{{Cite journal|last1=Genoux|first1=David|last2=Haditsch|first2=Ursula|last3=Knobloch|first3=Marlen|last4=Michalon|first4=Aubin|last5=Storm|first5=Daniel|last6=Mansuy|first6=Isabelle M.|date=August 2002|title=Protein phosphatase 1 is a molecular constraint on learning and memory|url=https://www.nature.com/articles/nature00928|journal=Nature|language=en|volume=418|issue=6901|pages=970–975|doi=10.1038/nature00928|pmid=12198546|bibcode=2002Natur.418..970G|s2cid=4402669|issn=1476-4687}}{{Cite journal|last1=Koshibu|first1=Kyoko|last2=Gräff|first2=Johannes|last3=Beullens|first3=Monique|last4=Heitz|first4=Fabrice D.|last5=Berchtold|first5=Dominik|last6=Russig|first6=Holger|last7=Farinelli|first7=Mélissa|last8=Bollen|first8=Mathieu|last9=Mansuy|first9=Isabelle M.|date=October 14, 2009|title=Protein Phosphatase 1 Regulates the Histone Code for Long-Term Memory|journal=Journal of Neuroscience|language=en|volume=29|issue=41|pages=13079–13089|doi=10.1523/JNEUROSCI.3610-09.2009|issn=0270-6474|pmid=19828821|pmc=6665317}}{{Cite journal|last1=Baumgärtel|first1=Karsten|last2=Genoux|first2=David|last3=Welzl|first3=Hans|last4=Tweedie-Cullen|first4=Ry Y.|last5=Koshibu|first5=Kyoko|last6=Livingstone-Zatchej|first6=Magdalena|last7=Mamie|first7=Céline|last8=Mansuy|first8=Isabelle M.|date=May 2008|title=Control of the establishment of aversive memory by calcineurin and Zif268|url=https://www.nature.com/articles/nn.2113|journal=Nature Neuroscience|language=en|volume=11|issue=5|pages=572–578|doi=10.1038/nn.2113|pmid=18425121|s2cid=7369635|issn=1546-1726}}

Mansuy's current research examines the epigenetic basis of complex brain functions and physiological changes in mammals with a focus on the mechanisms of epigenetic inheritance.{{Cite web|last=Henriques|first=Martha|title=Can the legacy of trauma be passed down the generations?|url=https://www.bbc.com/future/article/20190326-what-is-epigenetics|access-date=2020-07-15|website=www.bbc.com|language=en}}{{Cite web|date=July 12, 2017|title=Peut-on souffrir des tragédies vécues par nos ancêtres ?|url=https://www.franceculture.fr/conferences/palais-de-la-decouverte-et-cite-des-sciences-et-de-lindustrie/peut-souffrir-des|access-date=2021-02-25|website=France Culture|language=fr}} The goal is to determine how life experiences can influence mental and physical health across generations and what molecular mechanisms are involved. The research is focused on how adverse experiences in early life can lead to psychiatric and metabolic disorders. Mouse models and cellular systems are used to study non-coding RNAs, epigenetic factors and chromatin remodelling in the brain and germline, and elucidate how they are involved in the expression and subsequent transmission of environmentally-induced phenotypes. Her lab showed that the effects of traumatic stress in early life can be transmitted across multiple generations in mice{{Cite journal |last1=Franklin |first1=Tamara B. |author-link=Tamara Franklin |last2=Russig |first2=Holger |last3=Weiss |first3=Isabelle C. |last4=Gräff |first4=Johannes |last5=Linder |first5=Natacha |last6=Michalon |first6=Aubin |last7=Vizi |first7=Sandor |last8=Mansuy |first8=Isabelle M. |date=September 1, 2010 |title=Epigenetic Transmission of the Impact of Early Stress Across Generations |journal=Biological Psychiatry |series=Stress, Neuroplasticity, and Posttraumatic Stress Disorder |language=en |volume=68 |issue=5 |pages=408–415 |doi=10.1016/j.biopsych.2010.05.036 |issn=0006-3223 |pmid=20673872 |s2cid=15851484 |doi-access=free}}{{Cite journal |last1=van Steenwyk |first1=Gretchen |last2=Roszkowski |first2=Martin |last3=Manuella |first3=Francesca |last4=Franklin |first4=Tamara B. |author-link4=Tamara Franklin |last5=Mansuy |first5=Isabelle M. |date=April 1, 2018 |title=Transgenerational inheritance of behavioral and metabolic effects of paternal exposure to traumatic stress in early postnatal life: evidence in the 4th generation |url= |journal=Environmental Epigenetics |language=en |volume=4 |issue=2 |pages=dvy023 |doi=10.1093/eep/dvy023 |pmc=6190267 |pmid=30349741}} and that RNA in sperm is a vector of transmission.{{Cite journal|last1=Gapp|first1=Katharina|last2=Jawaid|first2=Ali|last3=Sarkies|first3=Peter|last4=Bohacek|first4=Johannes|last5=Pelczar|first5=Pawel|last6=Prados|first6=Julien|last7=Farinelli|first7=Laurent|last8=Miska|first8=Eric|last9=Mansuy|first9=Isabelle M.|date=May 2014|title=Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice|journal=Nature Neuroscience|volume=17|issue=5|pages=667–669|doi=10.1038/nn.3695|issn=1546-1726|pmc=4333222|pmid=24728267}} Recent work showed that blood factors are involved in transmission mechanisms{{Cite journal|last1=van Steenwyk|first1=Gretchen|last2=Gapp|first2=Katharina|last3=Jawaid|first3=Ali|last4=Germain|first4=Pierre-Luc|last5=Manuella|first5=Francesca|last6=Tanwar|first6=Deepak K|last7=Zamboni|first7=Nicola|last8=Gaur|first8=Niharika|last9=Efimova|first9=Anastasiia|last10=Thumfart|first10=Kristina M|last11=Miska|first11=Eric A |last12=Mansuy|first12=Isabelle M|date=October 9, 2020|title=Involvement of circulating factors in the transmission of paternal experiences through the germline|journal=The EMBO Journal|volume=39|issue=23|pages=e104579|doi=10.15252/embj.2020104579|pmid=33034389|pmc=7705452|issn=0261-4189|doi-access=free}} and have been validated in human subjects.{{Cite medRxiv |last1=Jawaid |first1=Ali |last2=Kunzi |first2=Marina |last3=Mansoor |first3=Mahgul |last4=Khan |first4=Zain Yar |last5=Abid |first5=Anooshay |last6=Taha |first6=Muhammad |last7=Rigotti |first7=Serena |last8=Thumfart |first8=Kristina |last9=Faisal |first9=Saba |last10=Chughtai |first10=Omar |last11=Mansuy |first11=Isabelle |date=August 14, 2020 |title=Distinct microRNA signature in human serum and germline after childhood trauma |language=en |medrxiv=10.1101/2020.08.11.20168393v1}}

• 2017 Elected member of the European Academy of Sciences{{Cite web|url=https://www.eurasc.org/user/309/isabelle-mansuy|title=European Academy of Sciences – Isabelle Mansuy|website=www.eurasc.org|access-date=2020-04-03}}
• 2016 Knight in the Order of the Legion of Honour, France{{Citation|title=Décret du 31 décembre 2015 portant promotion et nomination|url=https://www.legifrance.gouv.fr/affichTexte.do?cidTexte=JORFTEXT000031741925&categorieLien=id|access-date=2020-04-03}}
• 2011 Elected member of the Research Council of the Swiss National Science Foundation{{Cite web|title=SNSF Research Council: nine new members elected – SNF|url=http://www.snf.ch/en/researchinFocus/newsroom/Pages/news-181219-nine-new-members-of-the-research.aspx|access-date=2020-07-09|website=www.snf.ch}}
• 2011 Knight in the Order of Merit, France{{Citation|title=Décret du 14 novembre 2011 portant promotion et nomination|url=https://www.legifrance.gouv.fr/affichTexte.do?cidTexte=JORFTEXT000024795827&categorieLien=id|access-date=2020-07-22}}
• 2010 Elected member of the Swiss Academy of Medical Sciences{{Cite web|title=Senate|url=https://www.samw.ch/|access-date=2020-07-09|website=SAMS|language=en-GB}}
• 2008 Robert Bing Prize{{Cite web|title=Robert Bing Prize|url=https://www.samw.ch/|access-date=2020-07-09|website=SAMS|language=en-GB}}
• 2006 EMBO member{{Cite web|title=Find people in the EMBO Community|url=https://people.embo.org/profile/isabelle-mansuy|access-date=July 22, 2020|website=EMBO.org}}
• 2004 FEBS Anniversary Award{{Cite web|title=FEBS Anniversary Prize der GBM – Homepage der Gesellschaft für Biochemie und Molekularbiologie e.V.|url=https://gbm-online.de/preise-und-auszeichnungen-details/febs-anniversary-prize-der-gbm.html|access-date=2020-07-09|website=gbm-online.de}}
• 2004 Boehringer Ingelheim FENS Research Award{{Cite web|last=Office|first=FENS|title=Boehringer Ingelheim FENS Research Award 2004|url=https://www.fens.org/News-Activities/Awards/FENS-Awards/Boehringer-Ingelheim-FENS-Research-Award/2004/|access-date=2020-07-09|website=FENS.org|language=en|archive-date=2020-07-09|archive-url=https://web.archive.org/web/20200709141435/https://www.fens.org/News-Activities/Awards/FENS-Awards/Boehringer-Ingelheim-FENS-Research-Award/2004/|url-status=dead}}
• 2001 EMBO Young Investigator Program Award{{Cite web|title=Find an EMBO Young Investigator / EMBO Installation Grantee|url=https://yip-search.embo.org/#/yip/2241|access-date=2020-07-09|website=yip-search.embo.org}}
• 1997 Fyssen Foundation Research Award{{Cite web|title=Annuaires|url=http://www.fondationfyssen.fr/annuaire/|access-date=2020-07-09|website=Fondation Fyssen}}

{{refbegin|30em}}

• {{Cite journal |last1=Winder |first1=Danny G |last2=Mansuy |first2=Isabelle M |last3=Osman |first3=Mona |last4=Moallem |first4=Theodore M |last5=Kandel |first5=Eric R |date=1998 |title=Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin |journal=Cell |language=en |volume=92 |issue=1 |pages=25–37 |doi=10.1016/S0092-8674(00)80896-X |pmid=9489697 |s2cid=18429683 |doi-access=free}}
• {{Cite journal |last1=Mansuy |first1=Isabelle M |last2=Mayford |first2=Mark |last3=Jacob |first3=Betsy |last4=Kandel |first4=Eric R |last5=Bach |first5=Mary Elizabeth |date=1998 |title=Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory |journal=Cell |language=en |volume=92 |issue=1 |pages=39–49 |doi=10.1016/S0092-8674(00)80897-1 |pmid=9489698 |s2cid=11586300 |doi-access=free}}
• {{Cite journal |last1=Franklin |first1=Tamara B. |author-link=Tamara Franklin |last2=Saab |first2=Bechara J. |last3=Mansuy |first3=Isabelle M. |date=2012 |title=Neural mechanisms of stress resilience and vulnerability |journal=Neuron |language=en |volume=75 |issue=5 |pages=747–761 |doi=10.1016/j.neuron.2012.08.016 |pmid=22958817 |s2cid=16257483 |doi-access=free}}
• {{Cite journal |last1=Gräff |first1=Johannes |last2=Mansuy |first2=Isabelle M. |date=2008 |title=Epigenetic codes in cognition and behaviour |journal=Behavioural Brain Research |language=en |volume=192 |issue=1 |pages=70–87 |doi=10.1016/j.bbr.2008.01.021 |pmid=18353453 |s2cid=5788700}}
• {{Cite journal |last1=Franklin |first1=Tamara B. |author-link=Tamara Franklin |last2=Russig |first2=Holger |last3=Weiss |first3=Isabelle C. |last4=Gräff |first4=Johannes |last5=Linder |first5=Natacha |last6=Michalon |first6=Aubin |last7=Vizi |first7=Sandor |last8=Mansuy |first8=Isabelle M. |date=2010 |title=Epigenetic transmission of the impact of early stress across generations |journal=Biological Psychiatry |language=en |volume=68 |issue=5 |pages=408–415 |doi=10.1016/j.biopsych.2010.05.036 |pmid=20673872 |s2cid=15851484 |doi-access=free}}
• {{Cite book |last1=Mansuy |first1=Isabelle M. |url=https://books.google.com/books?id=9smxDwAAQBAJ&q=Reprenez+le+contr%C3%B4le+de+vos+g%C3%A8nes:+Am%C3%A9liorez+votre+vie+et+celles+de+vos+descendant+avec+l%27%C3%A9pig%C3%A9n%C3%A9tique |title=Reprenez le contrôle de vos gènes: Améliorez votre vie et celles de vos descendant avec l'épigénétique |last2=Gurret |first2=Jean-Michel |last3=Lefief-Delcourt |first3=Alix |publisher=Larousse |year=2019 |isbn=978-2035956262}}

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{{reflist}}

• [https://www.hifo.uzh.ch/en/research/mansuy.html Isabelle Mansuy] University of Zurich profile
• {{Google Scholar id|id=4iAFh5cAAAAJ}}
• [https://www.mansuylab.ch/ Mansuy Lab website]

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Category:Swiss neuroscientists

Category:Swiss women neuroscientists

Category:Academic staff of the University of Zurich

Category:Academic staff of ETH Zurich

Category:Epigeneticists

Category:Living people

Category:1965 births