Isopenicillin N epimerase

{{infobox enzyme

| Name = isopenicillin N epimerase

| EC_number = 5.1.1.17

| CAS_number = 88201-43-8

| GO_code = 0045439

| image =

| width =

| caption =

}}

In enzymology, an isopenicillin N epimerase ({{EnzExplorer|5.1.1.17}}) is an enzyme that catalyzes the chemical reaction

:isopenicillin N $\rightleftharpoons$ penicillin N

Hence, this enzyme has one substrate, isopenicillin N, and one product, penicillin N.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is penicillin N 5-amino-5-carboxypentanoyl-epimerase. This enzyme participates in penicillin and cephalosporin biosynthesis.

References

{{cite journal | doi = 10.1016/0167-4838(89)90033-2 |vauthors=Usui S, Yu CA | date = 1989 | title = Purification and properties of isopenicillin N epimerase from Streptomyces clavuligerus | journal = Biochim. Biophys. Acta | volume = 999 | pages = 78–85 | pmid = 2804141 | issue = 1 }}
{{cite journal |vauthors=Laiz L, Liras P, Castro JM, Martin JF | date = 1990 | title = Purification and characterization of the isopenicillin-N epimerase from Nocardia lactamdurans | journal = J. Gen. Microbiol. | volume = 136 | issue = 4 | pages = 663–671 | doi=10.1099/00221287-136-4-663| doi-access = free | hdl = 10261/63775 | hdl-access = free }}
{{cite journal |vauthors=Cantwell C, Beckmann R, Whiteman P, Queener SW, Abraham EP | date = 1992 | title = Isolation of deacetoxycephalosporin C from fermentation broths of Penicillium chrysogenum transformants: construction of a new fungal biosynthetic pathway | journal = Proceedings of the Royal Society B | volume = 248 | pages = 283–9 | pmid = 1354366 | doi = 10.1098/rspb.1992.0073 | issue = 1323 }}
{{cite journal |vauthors=Yeh WK, Ghag SK, Queener SW | date = 1992 | title = Enzymes for epimerization of isopenicillin N, ring expansion of penicillin N, and 3'-hydroxylation of deacetoxycephalosporin C Function, evolution, refolding, and enzyme engineering | journal = Ann. N.Y. Acad. Sci. | volume = 672 | issue = 1 Enzyme Engine | pages = 396–408 | doi = 10.1111/j.1749-6632.1992.tb32705.x }}

Category:EC 5.1.1

Category:Enzymes of unknown structure