Isopropyl acetate

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| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 442346934

| Name = Isopropyl acetate

| ImageFile = Isopropyl acetate.svg

| ImageAlt = Skeletal formula of isopropyl acetate

| ImageFile1 = Isopropyl acetate 3D ball.png

| ImageAlt1 = Ball-and-stick model of the isopropyl acetate molecule

|SystematicName = Propan-2-yl ethanoate

|IUPACName = Propan-2-yl acetate

| OtherNames = Isopropyl acetate
2-Acetoxypropane
2-Propyl acetate
2-Propyl ethanoate
Propan-2-yl ethanoate

| Section1 = {{Chembox Identifiers

| CASNo_Ref = {{cascite|correct|CAS}}

| CASNo = 108-21-4

| ChEMBL = 1608674

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 7627

| EC_number = 203-561-1

| PubChem = 7915

| RTECS = AI4930000

| UNNumber = 1220

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 1Y67AFK870

| SMILES = CC(OC(C)C)=O

| InChI = 1/C5H10O2/c1-4(2)7-5(3)6/h4H,1-3H3

| InChIKey = JMMWKPVZQRWMSS-UHFFFAOYAA

| StdInChI_Ref = {{stdinchicite|changed|chemspider}}

| StdInChI = 1S/C5H10O2/c1-4(2)7-5(3)6/h4H,1-3H3

| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}

| StdInChIKey = JMMWKPVZQRWMSS-UHFFFAOYSA-N

}}

| Section2 = {{Chembox Properties

| C=5 | H=10 | O=2

| Density = 0.87{{nbsp}}g/cm3

| Solubility = 4.3{{nbsp}}g/100{{nbsp}}mL (27{{nbsp}}°C), 3.0{{nbsp}}g/100{{nbsp}}mL (20{{nbsp}}°C)

| MeltingPtC = −73

| BoilingPtC = 89

| VaporPressure = 42{{nbsp}}mmHg (20{{nbsp}}°C)

| MagSus = −67.04·10−6{{nbsp}}cm3/mol

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| Section7 = {{Chembox Hazards

| GHSPictograms = {{GHS02}}{{GHS07}}

| GHSSignalWord = Danger

| HPhrases = {{H-phrases|225|319|336}}

| PPhrases = {{P-phrases|210|233|240|241|242|243|261|264|271|280|303+361+353|304+340|305+351+338|312|337+313|370+378|403+233|403+235|405|501}}

| NFPA-H = 1

| NFPA-F = 3

| NFPA-R =

| FlashPtC = 2

| AutoignitionPtC = 460

| ExploLimits = 1.8–7.8%

| IDLH = 1800{{nbsp}}ppm{{PGCH|0358}}

| PEL = TWA 250{{nbsp}}ppm (950{{nbsp}}mg/m3)

| REL = None established

| LC50 = 11,918{{nbsp}}ppm (rat, 8{{nbsp}}hr){{IDLH|108214|Isopropyl acetate}}

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Isopropyl acetate (commonly abbreviated IPAc or iPrOAc) is an ester, an organic compound which is the product of esterification of acetic acid and isopropanol. It is a clear, colorless liquid with a characteristic fruity odor.{{cite web| publisher= ChemViP| title= Isopropyl acetate| url= http://www.chemvip.com/index/products_index/all_products/all_products_solvents/product-isopropyl_acetate.htm| access-date= 2009-04-20| archive-date= 2012-07-15| archive-url= https://web.archive.org/web/20120715084747/http://www.chemvip.com/index/products_index/all_products/all_products_solvents/product-isopropyl_acetate.htm| url-status= dead}}

Isopropyl acetate is a solvent with a wide variety of manufacturing uses that is miscible with most other organic solvents and is slightly soluble in water (2.9 wt% at 20 °C), though less so than ethyl acetate. Inversely, water is also slightly soluble in isopropyl acetate (1.8 wt% at 20 °C).{{Cite web |title=Isopropyl Acetate (IPAc) - Monument Chemical |url=https://monumentchemical.com/uploads/files/TDS/IPAC_TDS.pdf?v=1635378483427 |access-date=May 29, 2025}} Isopropyl acetetate forms an azeotrope with water, allowing for anhydrous solutions to be easily achieved through evaporation with an azeotrope composition of 88.9 wt% isopropyl acetate.{{Cite patent|number=US4826576A|title=Separation of isopropyl acetate from isopropanol by extractive distillation|gdate=1989-05-02|invent1=Berg|invent2=Yeh|inventor1-first=Lloyd|inventor2-first=An-I.|url=https://patents.google.com/patent/US4826576A/en}} It is used as a solvent for cellulose, plastics, oil and fats. It is a component of some printing inks{{cite web|url=http://www.chemvip.com/index/products_index/all_products/all_products_solvents/product-isopropyl_acetate.htm|title=Celanese - The chemistry inside innovation™|work=chemvip.com|access-date=18 May 2015|archive-date=15 July 2012|archive-url=https://web.archive.org/web/20120715084747/http://www.chemvip.com/index/products_index/all_products/all_products_solvents/product-isopropyl_acetate.htm|url-status=dead}} and perfumes.

Isopropyl acetate decomposes slowly on contact with steel in the presence of air, producing acetic acid and isopropanol. It reacts violently with oxidizing materials and it attacks many plastics.{{cite web| publisher= International Chemical Safety Cards| title= ISOPROPYL ACETATE| url= http://actrav.itcilo.org/actrav-english/telearn/osh/ic/108214.htm| access-date= 2009-06-25| archive-url= https://web.archive.org/web/20110722053722/http://actrav.itcilo.org/actrav-english/telearn/osh/ic/108214.htm| archive-date= 2011-07-22| url-status= dead}}

Isopropyl acetate is quite flammable in both its liquid and vapor forms, and it may be harmful if swallowed or inhaled. {{ cite web| publisher= Material Safety Data Sheets| title= Iso-propyl Acetate|url=http://hazard.com/msds/mf/baker/baker/files/p6753.htm}}

The Occupational Safety and Health Administration has set a permissible exposure limit (PEL) of 250{{nbsp}}ppm (950{{nbsp}}mg/m3) over an eight-hour time-weighted average for workers handling isopropyl acetate. {{cite web| publisher=Centers for Disease Control and Prevention| title=NIOSH Pocket Guide to Chemical Hazards - Isopropyl acetate|url=https://www.cdc.gov/niosh/npg/npgd0358.html}}

References