JAG2

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.

JAG2 has been shown to interact with NOTCH2.{{cite journal |vauthors=Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H | title = Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2 | journal = Mol. Cell. Biol. | volume = 20 | issue = 18 | pages = 6913–22 | year = 2000 | pmid = 10958687 | pmc = 88767 | doi = 10.1128/MCB.20.18.6913-6922.2000 }}

MicroRNA miR-1280 has been shown to inhibit JAG2 expression.{{Cite journal|title = A MicroRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma|author = Wang|author2 = Remke|author3 = Bhat|author4 = Wong|author5 = Zhou|author6 = Ramaswamy|author7 = Dubuc|author8 = Fonkem|author9 = Salem|author10 = Zhang|author11 = Hsieh|author12 = O'Rourke|author13 = Wu|author14 = Li|author15 = Hawkins|author16 = Kohane|author17 = Wu|author18 = Wu|author19 = Taylor|date = February 2015|journal = Oncotarget|doi = 10.18632/oncotarget.2779|pmid = 25576913|volume=6| issue=5 |pages=2709–24|pmc=4413612}}

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• {{cite journal |vauthors=Shawber C, Boulter J, Lindsell CE, Weinmaster G | title = Jagged2: a serrate-like gene expressed during rat embryogenesis | journal = Dev. Biol. | volume = 180 | issue = 1 | pages = 370–6 | year = 1997 | pmid = 8948600 | doi = 10.1006/dbio.1996.0310 | doi-access = free }}
• {{cite journal |vauthors=Valsecchi C, Ghezzi C, Ballabio A, Rugarli EI | title = JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions | journal = Mech. Dev. | volume = 69 | issue = 1–2 | pages = 203–7 | year = 1998 | pmid = 9486542 | doi = 10.1016/S0925-4773(97)00146-9 | s2cid = 15978116 | doi-access = }}
• {{cite journal |vauthors=Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S | title = Human Ligands of the Notch Receptor | journal = Am. J. Pathol. | volume = 154 | issue = 3 | pages = 785–94 | year = 1999 | pmid = 10079256 | pmc = 1866435 | doi = 10.1016/S0002-9440(10)65325-4 }}
• {{cite journal |vauthors=Lanford PJ, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley T, Kelley MW | title = Notch signalling pathway mediates hair cell development in mammalian cochlea | journal = Nat. Genet. | volume = 21 | issue = 3 | pages = 289–92 | year = 1999 | pmid = 10080181 | doi = 10.1038/6804 | s2cid = 6801552 }}
• {{cite journal |vauthors=Felli MP, Maroder M, Mitsiadis TA, Campese AF, Bellavia D, Vacca A, Mann RS, Frati L, Lendahl U, Gulino A, Screpanti I | title = Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development | journal = Int. Immunol. | volume = 11 | issue = 7 | pages = 1017–25 | year = 1999 | pmid = 10383933 | doi = 10.1093/intimm/11.7.1017 | doi-access = free }}
• {{cite journal |vauthors=Tsai S, Fero J, Bartelmez S | title = Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact | journal = Blood | volume = 96 | issue = 3 | pages = 950–7 | year = 2000 | doi = 10.1182/blood.V96.3.950 | pmid = 10910909 }}
• {{cite journal |vauthors=Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H | title = Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2 | journal = Mol. Cell. Biol. | volume = 20 | issue = 18 | pages = 6913–22 | year = 2000 | pmid = 10958687 | pmc = 88767 | doi = 10.1128/MCB.20.18.6913-6922.2000 }}
• {{cite journal |vauthors=Shimizu K, Chiba S, Saito T, Kumano K, Hirai H | title = Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors | journal = Biochem. Biophys. Res. Commun. | volume = 276 | issue = 1 | pages = 385–9 | year = 2000 | pmid = 11006133 | doi = 10.1006/bbrc.2000.3469 }}
• {{cite journal |vauthors=Cereseto A, Tsai S | title = Jagged2 induces cell cycling in confluent fibroblasts susceptible to density-dependent inhibition of cell division | journal = J. Cell. Physiol. | volume = 185 | issue = 3 | pages = 425–31 | year = 2000 | pmid = 11056013 | doi = 10.1002/1097-4652(200012)185:3<425::AID-JCP13>3.0.CO;2-U | s2cid = 683811 }}
• {{cite journal |vauthors=Lindner V, Booth C, Prudovsky I, Small D, Maciag T, Liaw L | title = Members of the Jagged/Notch Gene Families Are Expressed in Injured Arteries and Regulate Cell Phenotype via Alterations in Cell Matrix and Cell-Cell Interaction | journal = Am. J. Pathol. | volume = 159 | issue = 3 | pages = 875–83 | year = 2001 | pmid = 11549580 | pmc = 1850458 | doi = 10.1016/S0002-9440(10)61763-4 }}
• {{cite journal |vauthors=Hayashi T, Kageyama Y, Ishizaka K, Xia G, Kihara K, Oshima H | title = Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes | journal = J. Androl. | volume = 22 | issue = 6 | pages = 999–1011 | year = 2002 | doi = 10.1002/j.1939-4640.2001.tb03441.x | pmid = 11700865 }}
• {{cite journal |vauthors=Ikeuchi T, Sisodia SS | title = The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage | journal = J. Biol. Chem. | volume = 278 | issue = 10 | pages = 7751–4 | year = 2003 | pmid = 12551931 | doi = 10.1074/jbc.C200711200 | doi-access = free }}
• {{cite journal |vauthors=Houde C, Li Y, Song L, Barton K, Zhang Q, Godwin J, Nand S, Toor A, Alkan S, Smadja NV, Avet-Loiseau H, Lima CS, Miele L, Coignet LJ | title = Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines | journal = Blood | volume = 104 | issue = 12 | pages = 3697–704 | year = 2004 | pmid = 15292061 | doi = 10.1182/blood-2003-12-4114 | doi-access = free }}
• {{cite journal |vauthors=Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 | doi-access = free }}

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{{Notch signaling pathway}}

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