JPH1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{about|the gene and protein Junctophilin-1|the racecar|Williams JPH1}}
{{Infobox_gene}}
Junctophilin-1 is a protein that in humans is encoded by the JPH1 gene.{{cite journal |vauthors=Nishi M, Mizushima A, Nakagawara K, Takeshima H | title = Characterization of human junctophilin subtype genes | journal = Biochem Biophys Res Commun | volume = 273 | issue = 3 | pages = 920–7 |date=Sep 2000 | pmid = 10891348 | doi = 10.1006/bbrc.2000.3011 }}{{cite journal |vauthors=Takeshima H, Komazaki S, Nishi M, Iino M, Kangawa K | title = Junctophilins: a novel family of junctional membrane complex proteins | journal = Mol Cell | volume = 6 | issue = 1 | pages = 11–22 |date=Aug 2000 | pmid = 10949023 | doi =10.1016/S1097-2765(05)00005-5 | doi-access = free }}{{cite web | title = Entrez Gene: JPH1 junctophilin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56704}}
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family.
References
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Further reading
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- {{cite journal | author=Takeshima H |title=Ryanodine receptor and junctional membrane structure. |journal=Nippon Yakurigaku Zasshi |volume=121 |issue= 4 |pages= 203–10 |year= 2003 |pmid= 12777839 |doi=10.1254/fpj.121.203 |doi-access=free }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
- {{cite journal |vauthors=Nusbaum C, Mikkelsen TS, Zody MC, etal |title=DNA sequence and analysis of human chromosome 8. |journal=Nature |volume=439 |issue= 7074 |pages= 331–5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 |bibcode=2006Natur.439..331N |doi-access= free }}
- {{cite journal |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |s2cid=27764390 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Komazaki S, Ito K, Takeshima H, Nakamura H |title=Deficiency of triad formation in developing skeletal muscle cells lacking junctophilin type 1. |journal=FEBS Lett. |volume=524 |issue= 1–3 |pages= 225–9 |year= 2002 |pmid= 12135771 |doi=10.1016/S0014-5793(02)03042-9 |s2cid=9826632 |doi-access= }}
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