JUNB
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene.{{cite journal |vauthors=Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J | title = jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun | journal = Cell | volume = 59 | issue = 6 | pages = 987–997 | date = Feb 1990 | pmid = 2513129 | doi = 10.1016/0092-8674(89)90755-1 | doi-access = free }}{{cite web | title = Entrez Gene: JUNB jun B proto-oncogene | url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&list_uids=3726&rn=1}} Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.
Interactions
JUNB has been shown to interact with
- BRCA1,{{cite journal |vauthors=Hu YF, Li R | title = JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction | journal = Genes Dev. | volume = 16 | issue = 12 | pages = 1509–17 | date = Jun 2002 | pmid = 12080089 | pmc = 186344 | doi = 10.1101/gad.995502 }} and
- SMAD3.{{cite journal |vauthors=Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF | title = Smads bind directly to the Jun family of AP-1 transcription factors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 9 | pages = 4844–9 | date = Apr 1999 | pmid = 10220381 | pmc = 21779 | doi = 10.1073/pnas.96.9.4844| bibcode = 1999PNAS...96.4844L | doi-access = free }}
See also
References
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Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Hsu JC, Bravo R, Taub R | title = Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration | journal = Mol. Cell. Biol. | volume = 12 | issue = 10 | pages = 4654–65 | year = 1992 | pmid = 1406655 | pmc = 360392 | doi = 10.1128/MCB.12.10.4654}}
- {{cite journal |vauthors=Zafarullah M, Martel-Pelletier J, Cloutier JM, Gedamu L, Pelletier JP | title = Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte | journal = FEBS Lett. | volume = 306 | issue = 2–3 | pages = 169–172 | year = 1992 | pmid = 1633872 | doi = 10.1016/0014-5793(92)80992-P | s2cid = 43460076 | doi-access = free | bibcode = 1992FEBSL.306..169Z }}
- {{cite journal |vauthors=Mollinedo F, Vaquerizo MJ, Naranjo JR | title = Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes | journal = Biochem. J. | volume = 273(Pt 2) | issue = 2| pages = 477–9 | year = 1991 | pmid = 1899335 | pmc = 1149869 | doi = 10.1042/bj2730477}}
- {{cite journal |vauthors=Nomura N, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R | title = Isolation of human cDNA clones of jun-related genes, jun-B and jun-D | journal = Nucleic Acids Res. | volume = 18 | issue = 10 | pages = 3047–3048 | year = 1990 | pmid = 2112242 | pmc = 330838 | doi = 10.1093/nar/18.10.3047 }}
- {{cite journal |vauthors=Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A | title = Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers | journal = Genomics | volume = 15 | issue = 1 | pages = 133–145 | year = 1993 | pmid = 8432525 | doi = 10.1006/geno.1993.1021 | url = https://zenodo.org/record/1229582 }}
- {{cite journal |vauthors=Phinney DG, Tseng SW, Ryder K | title = Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci | journal = Genomics | volume = 28 | issue = 2 | pages = 228–234 | year = 1996 | pmid = 8530030 | doi = 10.1006/geno.1995.1135 }}
- {{cite journal |vauthors=Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ | title = B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family | journal = Oncogene | volume = 11 | issue = 11 | pages = 2255–65 | year = 1996 | pmid = 8570175 }}
- {{cite journal |vauthors=Neyns B, Vermeij J, Bourgain C, Vandamme B, Amfo K, Lissens W, DeSutter P, Hooghe-Peters E, DeGrève J | title = Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium | journal = Oncogene | volume = 12 | issue = 6 | pages = 1247–57 | year = 1996 | pmid = 8649827 }}
- {{cite journal |vauthors=Mendelson KG, Contois LR, Tevosian SG, Davis RJ, Paulson KE | title = Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 23 | pages = 12908–12913 | year = 1996 | pmid = 8917518 | pmc = 24019 | doi = 10.1073/pnas.93.23.12908 | bibcode = 1996PNAS...9312908M | doi-access = free }}
- {{cite journal |vauthors=Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M | title = Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions | journal = Mol. Cell. Biol. | volume = 17 | issue = 6 | pages = 3094–102 | year = 1997 | pmid = 9154808 | pmc = 232162 | doi = 10.1128/mcb.17.6.3094}}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
- {{cite journal |vauthors=Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z | title = c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors | journal = J. Biol. Chem. | volume = 272 | issue = 51 | pages = 32163–32168 | year = 1998 | pmid = 9405416 | doi = 10.1074/jbc.272.51.32163 | doi-access = free }}
- {{cite journal |vauthors=Venugopal R, Jaiswal AK | title = Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes | journal = Oncogene | volume = 17 | issue = 24 | pages = 3145–3156 | year = 1999 | pmid = 9872330 | doi = 10.1038/sj.onc.1202237 | doi-access = free }}
- {{cite journal |vauthors=Li B, Tournier C, Davis RJ, Flavell RA | title = Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation | journal = EMBO J. | volume = 18 | issue = 2 | pages = 420–432 | year = 1999 | pmid = 9889198 | pmc = 1171136 | doi = 10.1093/emboj/18.2.420 }}
- {{cite journal |vauthors=Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF | title = Smads bind directly to the Jun family of AP-1 transcription factors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 9 | pages = 4844–4849 | year = 1999 | pmid = 10220381 | pmc = 21779 | doi = 10.1073/pnas.96.9.4844 | bibcode = 1999PNAS...96.4844L | doi-access = free }}
- {{cite journal |vauthors=Chen P, Flory E, Avots A, Jordan BW, Kirchhoff F, Ludwig S, Rapp UR | title = Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors | journal = J. Biol. Chem. | volume = 275 | issue = 27 | pages = 20382–20390 | year = 2000 | pmid = 10764760 | doi = 10.1074/jbc.M001149200 | doi-access = free }}
- {{cite journal |vauthors=Echlin DR, Tae HJ, Mitin N, Taparowsky EJ | title = B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos | journal = Oncogene | volume = 19 | issue = 14 | pages = 1752–1763 | year = 2000 | pmid = 10777209 | doi = 10.1038/sj.onc.1203491 | doi-access = free }}
- {{cite journal |vauthors=Verrecchia F, Pessah M, Atfi A, Mauviel A | title = Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation | journal = J. Biol. Chem. | volume = 275 | issue = 39 | pages = 30226–30231 | year = 2000 | pmid = 10903323 | doi = 10.1074/jbc.M005310200 | url = http://www.hal.inserm.fr/inserm-00150046 | doi-access = free }}
- {{cite journal |vauthors=Singh K, Camera E, Krug L, Basu A, Pandey RK, Munir S, Wlaschek M, Kochanek S, Schorpp-Kistner M, Picardo M, Angel P, Niemann C, Maity P, Scharffetter-Kochanek K | title = JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin | journal = Nature | volume = 9 | issue = 1 | year = 2018 | page = 3425 | pmid = 30143626 | doi = 10.1038/s41467-018-05726-z | pmc = 6109099 | bibcode = 2018NatCo...9.3425S | doi-access = free }}
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External links
- {{MeshName|JUNB+protein,+human}}
{{NLM content}}
{{Transcription factors|g1}}
Category:Transcription factors
{{gene-19-stub}}