JZL195

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| ImageFile = JZL-195 Structure.svg

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| PIN = 4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate

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|Section1={{Chembox Identifiers

| CASNo = 1210004-12-8

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = TP6P2HKJ54

| PubChem = 46232606

| ChemSpiderID = 24655100

| ChEMBL = 606201

| SMILES = c1ccc(cc1)Oc2cccc(c2)CN3CCN(CC3)C(=O)Oc4ccc(cc4)[N+](=O)[O-]

| StdInChI = 1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2

| StdInChIKey = QNYRAEKLMNDRFY-UHFFFAOYSA-N

}}

|Section2={{Chembox Properties

| C=24 | H=23 | N=3 | O=5

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|Section3={{Chembox Hazards

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JZL195 is a potent inhibitor of both fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the primary enzymes responsible for degrading the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively.{{cite journal | vauthors = Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF | title = Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 48 | pages = 20270–5 | date = December 2009 | pmid = 19918051 | pmc = 2787168 | doi = 10.1073/pnas.0909411106 | bibcode = 2009PNAS..10620270L | doi-access = free }}

See also

References