Jay Shendure

{{short description|American geneticist}}

{{infobox scientist/Wikidata

|fetchwikidata = ALL

|thesis_url = https://www.proquest.com/docview/305001213

|thesis_year = 2005

|website = {{url|krishna.gs.washington.edu}}

}}

Jay Shendure is an American scientist and human geneticist at the University of Washington. He is a professor in the Department of Genome Sciences at the University of Washington School of Medicine{{cite web|url=http://www.gs.washington.edu/faculty/shendure.htm |title=Jay Shendure |publisher=UW Genome Sciences |date= |access-date=2014-02-04}} and an Affiliate Investigator in the Human Biology Division at the Fred Hutchinson Cancer Research Center.{{cite web|url=https://www.fhcrc.org/en/labs/profiles/shendure-jay.html |title=Jay Shendure, MD, PhD |publisher=Fred Hutchinson Cancer Research Center |date= |access-date=2014-02-04}}

Shendure's research is focused on developing and applying new technologies in genomics. In 2005, his doctoral research with George M. Church resulted one of the first successful proof-of-concepts of next-generation DNA sequencing.{{cite news|url=https://www.nytimes.com/2005/08/09/science/09dna.html|title=2 New Methods to Sequence DNA Promise Vastly Lower Costs|author=Nicholas Wade|newspaper=The New York Times|access-date=2014-02-04}}{{cite web|url=http://www.nature.com/milestones/miledna/full/miledna18.html |title=Milestone 18 : Nature Milestones in DNA |work=Nature |date=2007-10-15 |access-date=2014-02-04}}{{Cite journal

| last1 = Eichler | first1 = E. E.

| title = 2012 Introduction to the Curt Stern Award: Jay Shendure

| doi = 10.1016/j.ajhg.2012.11.019

| journal = The American Journal of Human Genetics

| volume = 92

| issue = 3

| pages = 338–339

| year = 2013

| pmid = 23472755

| pmc =3591784

}} Shendure's research group at the University of Washington pioneered exome sequencing and its application to Mendelian disorders,{{cite web |author=Elie Dolgin |url=http://www.nature.com/news/2009/091113/full/news.2009.1085.html |title=Selective sequencing solves a genetic mystery : Nature News |work=Nature |date=2009-11-13 |access-date=2014-02-04}} a strategy that has been applied to identify hundreds of disease-causing genes.{{cite journal|author=Jocelyn Kaiser |url=https://www.science.org/doi/abs/10.1126/science.330.6006.903 |title=Affordable 'Exomes' Fill Gaps in a Catalog of Rare Diseases |journal=Science |date=2010-11-12 |volume=330 |issue=6006 |page=903 |doi=10.1126/science.330.6006.903 |pmid=21071642 |access-date=2014-02-04|doi-access=free }} Other notable accomplishments of Shendure's laboratory include the first whole genome sequencing of a human fetus using samples obtained non-invasively from the parents,{{cite news|url=https://www.nytimes.com/2012/06/07/health/tests-of-parents-are-used-to-map-genes-of-a-fetus.html?hp |title=DNA Blueprint for Fetus Built Using Tests of Parents|author=Andrew Pollack|newspaper=The New York Times|access-date=2014-02-04}}{{cite web|last=Lopatto |first=Elizabeth |url=https://www.bloomberg.com/news/2012-06-06/blood-saliva-analysis-may-replace-invasive-prenatal-test.html |title=Blood-Saliva Analysis May Replace Invasive Prenatal Test |publisher=Bloomberg |date=2012-06-06 |access-date=2014-02-04}} and the sequencing of the HeLa genome in agreement with Henrietta Lacks' family.{{cite news |url=https://www.nytimes.com/2013/08/08/science/after-decades-of-research-henrietta-lacks-family-is-asked-for-consent.html?pagewanted=all&_r=1& |title=After Decades of Research Henrietta Lack's Family is Asked for Consent|newspaper=The New York Times |access-date=2014-02-04}}{{cite web |author= |url=http://www.nature.com/news/deal-done-over-hela-cell-line-1.13511 |title=Deal done over HeLa cell line : Nature News & Comment |work=Nature |date=2013-08-07 |access-date=2014-02-04}}{{cite journal |title=Biospecimen policy: Family matters |journal=Nature |volume=500 |issue=7461 |doi=10.1038/500141a |pmid=23925224 |pages=141–142|year=2013 |last1=Hudson |first1=Kathy L. |last2=Collins |first2=Francis S. |pmc=5101952 |bibcode=2013Natur.500..141H }}

Shendure graduated summa cum laude from Princeton University in 1996 and completed a Fulbright scholarship at Pune, India, in 1997. He then entered the Medical Scientist Training Program at Harvard Medical School and received his Ph.D. in 2005 and his M.D. in 2007. He joined the faculty at the Department of Genome Sciences at the University of Washington in 2007 and was tenured as an associate professor four years later in 2011.

Shendure is a 2006 recipient of the TR35 Young Innovator Award from MIT Technology Review,{{cite web |author= |url=http://www2.technologyreview.com/tr35/Profile.aspx?TRID=458 |archive-url=https://web.archive.org/web/20090929001723/http://www.technologyreview.com/tr35/Profile.aspx?TRID=458 |url-status=dead |archive-date=September 29, 2009 |title=Innovator Under 35: Jay Shendure, 31 – MIT Technology Review |work=MIT Technology Review |date= |access-date=2014-02-04 }} the Curt Stern Award from the American Society of Human Genetics in 2012,{{cite web |url=http://www.ashg.org/pdf/PR_2012_CurtStern.pdf |title=American Society of Human Genetics Honors Dr. Jay Shendure with Curt Stern Award for 2012 |publisher=American Society of Human Genetics |access-date=2014-02-04 |archive-date=2016-11-09 |archive-url=https://web.archive.org/web/20161109172119/http://www.ashg.org/pdf/PR_2012_CurtStern.pdf |url-status=dead }} the FederaPrijs from the Federation of Dutch Medical Scientific Societies in 2013,{{cite web|url=http://www.federa.org/prijswinnaar-federa-2013 |title=Prijswinnaar Federa 2013 | Stichting Federatie van Medisch Wetenschappelijke Verenigingen |publisher=Federa.org |date= |access-date=2014-02-04}} a National Institutes of Health Director's Pioneer Award in 2013,{{cite web|url=http://commonfund.nih.gov/pioneer/Recipients13 |title=NIH Director's Pioneer Award Program – 2013 PioneerAward Recipients |publisher=NIH Common Fund |date=2013-12-04 |access-date=2014-02-04}} and a Howard Hughes Medical Investigator Award. He is also the founding Scientific Director of the Brotman-Baty Institute established in 2017 through a gift from Jeffrey H. and Susan Brotman, and Daniel R. and Pamela L. Baty.