Jayne S. Danska
{{Short description|Immunologist in Canada}}
{{Use mdy dates|date=November 2022}}
Jayne S. Danska is an immunologist in Canada. Danska is a Senior Scientist at the Hospital for Sick Children, a Professor at the University of Toronto's Faculty of Medicine, and the Anne and Max Tanenbaum Chair in Molecular Medicine.{{Cite web |last=Government of Canada |first=Canadian Institutes of Health Research |date=2013-01-11 |title=Biographies: College Chairs - CIHR |url=https://cihr-irsc.gc.ca/e/49802.html |access-date=2022-10-20 |website=cihr-irsc.gc.ca}}{{Cite news |last=Khaja |first=Mariyam |date=19 July 2022 |title=Two Experts On How To Protect Yourself From BA.4 And BA.5 |work=Chatelaine |url=https://www.chatelaine.com/health/covid-19-wave-variants-vaccines-masking/}}{{Cite web |title=Jayne Danska |url=https://medbio.utoronto.ca/faculty/danska |access-date=2022-10-20 |website=medbio.utoronto.ca |language=en}}
Research
Danska holds a PhD in Genetics and Molecular Biology from Cornell University.{{Cite web |title=Jayne Danska {{!}} SickKids Directory |url=https://www.sickkids.ca/en/staff/d/jayne-danska/ |access-date=2022-10-20 |website=SickKids |language=en}} Her lab's research involves using both animal models and humans to investigate the mechanisms underlying immune system diseases (such as Type 1 diabetes), and improve diagnosis, prevention and treatment.{{Cite web |date=2008-03-20 |title=Sponsored {{!}} The people behind the breakthroughs |url=https://www.thestar.com/sponsored_sections/2008/03/20/the_people_behind_the_breakthroughs.html |access-date=2022-10-20 |website=thestar.com |language=en}} Danska is also one of the 14 researchers involved in the Integrated Microbiome Platforms for Advancing Causation Testing and Translation (IMPACTT), a pan-Canadian cross-disciplinary group conducting microbiome research.{{Cite web |date=2019-02-11 |title=University of Calgary to lead pan-Canadian microbiome research core |url=https://ucalgary.ca/news/university-calgary-lead-pan-canadian-microbiome-research-core |access-date=2022-10-20 |website=News |language=en}}
Previously, Danska's research found that in children with acute lymphoblastic leukemia, at the time of diagnosis, subpopulations of leukemic cells can cause a relapse. Additionally, in collaboration with John Dick, research from Danska's lab has previously led to the discovery of a gene (SIRPalpha) which can both support and destroy the growth of human blood stem cells, and was used to enable the successful grafting of stem cells from human bone marrow into mice.{{Cite web |date=2007-11-05 |title=Step forward in stem cell transplant research |url=https://www.ctvnews.ca/step-forward-in-stem-cell-transplant-research-1.262894?cache=trxjaxqprxeg%3FclipId%3D89750 |access-date=2022-10-20 |website=CTVNews |language=en}} Ultimately, the researchers aim to develop a therapy to allow more children with blood diseases to receive life-saving bone marrow transplants.
In 2022, Danska was selected as one of Canada's Most Powerful Women: Top 100.{{Cite web |title=Top 100 Award Winners 2022 - WXN |url=https://wxnetwork.com/page/2022Top100AwardWinners}} She has spoken about different aspects of the COVID-19 pandemic, including the BA.4 And BA.5 SARS-CoV-2 variants, and the expected changes in menstruation after taking a COVID-19 vaccine.{{Cite web |last=Taylor |first=Brooke |date=2021-04-16 |title=Menstrual changes to be expected after COVID-19 vaccine, during pandemic: experts |url=https://www.ctvnews.ca/health/coronavirus/menstrual-changes-to-be-expected-after-covid-19-vaccine-during-pandemic-experts-1.5391236 |access-date=2022-10-20 |website=Coronavirus |language=en}}
Danska has published over 140 academic papers, which have been collectively cited over 8,000 times.{{Cite web |title=Jayne Danska |url=https://scholar.google.ca/citations?user=ybUzi40AAAAJ&hl=en |access-date=2022-10-20 |website=scholar.google.ca}}
Selected academic publications
- Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. Micha J Rapoport, A Jaramillo, D Zipris, AH Lazarus, DV Serreze, EH Leiter, P Cyopick, JS Danska, and TL Delovitch. 1997. Journal of Experimental Medicine.
- Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Katsuto Takenaka, Tatiana K Prasolava, Jean CY Wang, Steven M Mortin-Toth, Sam Khalouei, Olga I Gan, John E Dick, and Jayne S Danska. 2007. Nature Immunology.
- Stem cell gene expression programs influence clinical outcome in human leukemia. Kolja Eppert, Katsuto Takenaka, Eric R Lechman, Levi Waldron, Björn Nilsson, Peter Van Galen, Klaus H Metzeler, Armando Poeppl, Vicki Ling, Joseph Beyene, Angelo J Canty, Jayne S Danska, Stefan K Bohlander, Christian Buske, Mark D Minden, Todd R Golub, Igor Jurisica, Benjamin L Ebert, and John E Dick. 2011. Nature Medicine.
- Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Janet GM Markle, Daniel N Frank, Steven Mortin-Toth, Charles E Robertson, Leah M Feazel, Ulrike Rolle-Kampczyk, Martin Von Bergen, Kathy D McCoy, Andrew J Macpherson, and Jayne S Danska. 2013. Science.
References
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Category:Canadian immunologists
Category:Year of birth missing (living people)
Category:21st-century Canadian physicians
Category:21st-century Canadian women physicians
Category:Cornell University alumni
Category:21st-century Canadian women scientists