Jessica Kramer

Kramer attended the University of Utah where she received an Honors Bachelor’s Degree of Science in Chemistry, following the biochemistry track. Kramer’s research under C. Dale Poulter contributed to her honors thesis, The Binding Specificity of Phospholipase C.{{Cite web|url=https://chem.utah.edu/directory/poulter/|title=C. Dale Poulter - Department of Chemistry - The University of Utah|website=chem.utah.edu}} She then pursued a Ph.D. in Organic Chemistry at the University of California, Los Angeles, where she worked with Dr. Timothy Deming as her research advisor.{{Cite web|url=https://www.chemistry.ucla.edu/directory/deming-timothy-j|title=Deming, Timothy J. | UCLA Chemistry and Biochemistry|website=www.chemistry.ucla.edu}}{{Cite web|url=http://deming.seas.ucla.edu/timdeming.html|title=Home Page|website=deming.seas.ucla.edu}} After graduate school, Kramer was awarded a University of California Chancellor’s Postdoctoral Fellowship at the University of California, Berkeley while working with Carolyn Bertozzi. Kramer was also awarded a National Institute of Health NRSA Postdoctoral Fellowship. During her fellowship at UC Berkeley, the Bertozzi lab moved to Stanford University, where Kramer continued her research.{{Cite web|url=https://chemistry.stanford.edu/people/carolyn-bertozzi|title=Carolyn Bertozzi | Department of Chemistry|website=chemistry.stanford.edu}}{{Cite web|url=http://bertozzigroup.stanford.edu/|title=Bertozzi Research Group|website=bertozzigroup.stanford.edu}}

Kramer began her career working in industrial research at Echelon Biosciences Inc. in Salt Lake City, Utah as a staff scientist during her undergraduate studies. She was part of a team synthesizing isoprenoid, phosphoinositide, and phospholipid product lines.{{Cite web|url=https://echelon-inc.com/|title=Home|website=Echelon Biosciences}} She also interned at HRL Laboratories in Malibu, California, where she worked with microbial fuel cells.{{Cite web |url=http://www.hrl.com/laboratories/labs_sml.html |title=Sensors and materials Lab (SML) |access-date=2020-07-31 |archive-date=2017-12-21 |archive-url=https://web.archive.org/web/20171221194444/http://www.hrl.com/laboratories/labs_sml.html |url-status=dead }}

Kramer has contributed to the field of glycopolypeptide research. During her graduate studies, she and Deming produced the first living polymerization of glycosylated NCAs utilizing C-linked sugars and linking lysine via amides to improve stability. These can be used as mimics of natural glycoproteins.Kramer JR, Deming TJ, Glycopolypeptides via living polymerization of glycosylated-L-lysine N-carboxyanhydrides. J Am Chem Soc 2010 Oct 27;132(42):15068-71 Additionally, she developed a purification method for α-amino acid-N-carboxyanhydride (NCA) monomers using flash chromatography. This purification method results in improved yields compared to recrystallization and is useful for purifying NCAs that are difficult to crystallize.Kramer JR, Deming TJ, General method for purification of a-amino acid-n-carboxyanhydrides using flash chromatography.Biomacromolecules 2010 Dec 13;11(12):3668-72 Kramer has also researched bioconjugation reactions of methionine, determining different electrophiles that can react efficiently with methionine, and the lack of pH effects.Kramer JR, Deming TJ, Reversible chemoselective tagging and functionalization of methionine containing peptides. Chem Commun (Camb) 2013 Jun 7;49(45):5144-6

While completing her postdoctoral fellowship under Bertozzi, she studied the synthesis of protein glycodomain mimetics. Kramer designed a synthetic route to produce mucin glycodomain constructs using NCA polymerization. This research furthered mucin knowledge regarding its structure and properties.Kramer JR, Onoa B, Bustamante C, Bertozzi CR, Chemically tunable mucin chimeras assembled on living cells. Proc Natl Acad Sci U S A 2015 Oct 13;112(41):12574-9 With the Bertozzi lab, Kramer explored design and synthesis of specific glycopolypeptide ligands for receptors that play a critical role in microbial pathogen immunity. This was accomplished by using polymerization of glycosylated N-carboxyanhydrides.Zhou MN, Delaveris CS, Kramer JR, Kenkel JA, Engleman EG, Bertozzi CR, N-Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen-Presenting Cells through Dectin-1 and Dectin-2. Angew Chem Int Ed Engl 2018 Mar 12;57(12):3137-3142

Currently, the Kramer Lab at the University of Utah is developing methods for glycocalyx engineering to study the surface of cancerous cells with long-term goals of new diagnostics and treatments for various types of cancer. Additionally, Kramer’s lab is researching cryopreservation of tissue and whole organs, as well as the development of synthetic human mucus.{{Cite web|url=https://my.eng.utah.edu/~jessicak/research.html|title=Jessica Kramer, Ph.D.|website=my.eng.utah.edu}}

• NSF Career Award (2019){{Cite web|url=https://www.coe.utah.edu/2019/02/26/nsf-career-award-recipients/|title=NSF CAREER Award Recipients|date=February 26, 2019}}
• International Dream Chemistry Award (2017){{Cite web|url=https://www.coe.utah.edu/2017/12/06/jessica-kramer-receives-international-award/|title=Jessica Kramer Receives International Award|date=December 6, 2017}}
• Henkel Award for Outstanding Graduate Research in Polymer Chemistry, American Chemical Society (2015){{Cite web|url=https://pmsedivision.org/graduate-research-award/|title=Henkel Award for Outstanding Graduate Research in Polymer Science and Engineering – PMSE}}
• Norma Stoddart Prize, UCLA Department of Chemistry (2013){{Cite web|url=https://www.chemistry.ucla.edu/news/2013-departmental-awards-ceremony|title=2013 Departmental Awards Ceremony | UCLA Chemistry and Biochemistry|website=www.chemistry.ucla.edu}}

• [https://pubweb.eng.utah.edu/~jessicak/research.html The Kramer Lab]

{{DEFAULTSORT:Kramer, Jessica}}

Category:Living people

Category:Year of birth missing (living people)

Category:University of Utah faculty

Category:University of Utah alumni

Category:University of California, Los Angeles alumni