Joffroy's sign

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Joffroy's sign is a clinical sign in which there is a lack of wrinkling of the forehead when a patient looks up with the head bent forwards.{{cite journal|last=Woods|first=Alan|title=The Ocular Changes of Primary Diffuse Toxic Goitre A Review|journal=Medicine|date=May 1946|volume=25|issue=2|pages=113–154|doi=10.1097/00005792-194605000-00002|doi-access=free}} It occurs in patients with exophthalmos in Graves disease.{{cite journal|last=Means|first=JH|title=The Nature of Graves' Disease With Special Reference to Its Ophthalmic Component|journal=American Journal of the Medical Sciences|date=January 1944|volume=207|issue=1|pages=1–18|doi=10.1097/00000441-194401000-00001}}

The sign is named after Alexis Joffroy.