John Oghalai

Oghalai grew up in Madison (Wisconsin) with his father Rahim, mother Karen (née Herbert), and brother Mark, who also became a doctor.{{cite news |title=Masons cite scholars |work=Wisconsin State Journal |date=17 May 1986}}{{cite news |title=Obituary - Maxwell Herbert |work=Detroit Free Press, p. 21 |date=21 May 1995}}{{cite news |title=Engagements - Williams/Oghalai |work=Wisconsin State Journal |date=5 August 2001}} Oghalai went to a Madison High School and became an Eagle Scout in 1983.{{cite news |title=Three Boy Scouts get Eagle Awards Eagle Awards |work=Wisconsin State Journal |date=29 March 1983}}

He received a Bachelor of Science degree in electrical engineering in 1990, and his medical degree in 1994, both at the University of Wisconsin at Madison.{{cite journal |title=Graduation: Bioengeneering |journal=Rice University General Announcements |date=2006 |volume=2006/07 |page=103 |url=http://www.archive.org/details/riceuniversityge200607hous |access-date=30 March 2023}}

In 2003, Oghalai joined the faculty at the Baylor College of Medicine as an assistant professor.{{cite news |last1=Sharos |first1=David |title=Volume of hearing loss rising |url=https://www.chicagotribune.com/news/ct-xpm-2006-01-28-0601280035-story.html |access-date=13 January 2023 |work=Chicago Tribune |date=28 January 2006}}{{cite web |title=Faculty: John S. Oghalai |url=https://keck.usc.edu/otolaryngology/faculty/john-s.-oghalai |website=keck.usc.edu |publisher=University of Southern California |access-date=28 February 2023}} He served as director at The Hearing Center at Texas Children's Hospital in Houston, TX in 2005.{{cite news |last1=Irvine |first1=Martha |title=What's that?; Experts say increased headphone use exacerbates hearing loss in youth |work=The Record (Kitchener, Ont.) |date=23 September 2005}} He became an associate professor at Baylor in 2009.{{cite news |last1=Beam |first1=Christopher |title=Can You Hear Without Ears? Can you smell without a nose? |url=https://slate.com/news-and-politics/2007/03/can-you-hear-and-smell-if-they-cut-off-your-ears-and-nose.html |access-date=13 January 2023 |work=Slate |date=21 March 2007}}

In 2010, Oghalai moved to Stanford University School of Medicine as an associate professor and became a full professor in 2015. He became professor of otolaryngology and director of the Children’s Hearing Center at Stanford’s Lucile Packard Children's Hospital in 2016.

In 2017, Oghalai moved to University of Southern California{{cite news |last1=Strickland |first1=Anais |title=Appointments, Resignations, Deaths |url=https://www.chronicle.com/article/appointments-resignations-deaths-5-5-2017/ |access-date=12 January 2023 |work=The Chronicle of Higher Education |date=30 April 2017}} to become chair of the Caruso Department of Otolaryngology at the Keck School of Medicine.{{cite news |last1=Becker |first1=Rachel |title=Weaponizing sound: could sonic devices have injured diplomats in Cuba? |url=https://www.theverge.com/2017/9/16/16316048/sonic-weapon-cuba-us-canadian-diplomats-ultrasound-infrasound-science |access-date=13 January 2023 |work=Verge |date=16 September 2017}}

As an otolaryngology clinician, Oghalai has treated patients with issues that include noise-induced hearing loss, benign paroxysmal positional vertigo (BPPV), Bell’s palsy and Ramsay Hunt Syndrome.{{cite magazine |last1=Mier |first1=Tomás |title=Justin Bieber's Facial Paralysis Could Take 'Months' to Heal, Experts Say |url=https://www.rollingstone.com/music/music-news/justin-bieber-facial-paralysis-ramsay-hunt-syndrome-experts-1366507/ |access-date=13 January 2023 |magazine=Rolling Stone |date=10 June 2022}} In addition, Oghalai treated rare diseases such as cholesteatoma.{{cite journal| author=Kuo CL, Lien CF, Shiao AS| title=Mastoid obliteration for pediatric suppurative cholesteatoma: long-term safety and sustained effectiveness after 30 years' experience with cartilage obliteration. | journal=Audiol Neurootol | year= 2014 | volume= 19 | issue= 6 | pages= 358–69 | pmid=25377728 | doi=10.1159/000363685 | pmc= | s2cid=30283836 | url=https://pubmed.ncbi.nlm.nih.gov/25377728 }}{{cite journal| author=Egilmez OK, Hanege FM, Kalcioglu MT, Kaner T, Kokten N| title=Tegmen tympani defect and brain herniation secondary to mastoid surgery: case presentation. | journal=Case Rep Otolaryngol | year= 2014 | volume= 2014 | issue= | pages= 756280 | pmid=25140266 | doi=10.1155/2014/756280 | pmc=4129166 | doi-access=free }}{{cite journal| author=McMurphy AB, Oghalai JS| title=Repair of iatrogenic temporal lobe encephalocele after canal wall down mastoidectomy in the presence of active cholesteatoma. | journal=Otol Neurotol | year= 2005 | volume= 26 | issue= 4 | pages= 587–94 | pmid=16015151 | doi=10.1097/01.mao.0000178119.46290.e1 | pmc= | s2cid=37589021 | url=https://pubmed.ncbi.nlm.nih.gov/16015151 }}

In a 2000 study, Oghalai and colleagues examined incidence of benign paroxysmal positional vertigo (BPPV) in geriatric patients at a Houston hospital. They found that 9% of the sample population had undiagnosed BPPV, a predictor of fall risk, depression, and difficulties with daily activities.{{cite journal |last1=Laurent |first1=G |last2=Vereeck |first2=L |last3=Verbecque |first3=E |last4=Herssens |first4=N |last5=Casters |first5=L |last6=Spildooren |first6=J |title=Effect of age on treatment outcomes in benign paroxysmal positional vertigo: A systematic review |journal=Journal of the American Geriatrics Society |date=2022 |volume=70 |issue=1 |pages=281–293 |doi=10.1111/jgs.17485|pmid=34698378 |s2cid=239888032 |doi-access=free |hdl=1942/35743 |hdl-access=free }}{{cite journal |last1=Oghalai |first1=JS |last2=Manolidis |first2=S |last3=Barth |first3=JL |last4=Stewart |first4=MG |last5=Jenkins |first5=HA |title=Unrecognized Benign Paroxysmal Positional Vertigo in Elderly Patients |journal=Otolaryngology–Head and Neck Surgery |date=2000 |volume=122 |issue=5 |pages=630–634 |doi=10.1016/S0194-5998(00)70187-2|pmid=10793337 |s2cid=33401924 }}

To help understand mechanisms of hearing loss brought on by explosive pressures such as those soldiers experience when exposed to roadside bombs, in 2013 Oghalai and his team studied blast effects on hearing in mice. They found that the main traumatic damage leading to noise-induced hearing loss was to cochlear hair and nerve cells,{{cite journal |last1=Kindt |first1=Katie S |last2=Sheets |first2=Lavinia |title=Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish |journal=Frontiers in Cell and Developmental Biology |date=2018 |volume=6 |page=114 |doi=10.3389/fcell.2018.00114 |pmid=30258843 |pmc=6143809 |doi-access=free }} the cells responsible for translating pressure waves into the nerve signals in hearing.{{cite journal |last1=Cho |first1=Sung-Il |last2=Simon |first2=S. Gao |last3=Xia |first3=Anping |last4=Wang |first4=Rosalie |last5=Salles |first5=Felipe T. |last6=Raphael |first6=Patrick D. |last7=Abaya |first7=Homer |last8=Wachte |first8=Jacqueline |last9=Baek |first9=Jongmin |last10=Jacobs |first10=David |last11=Rasband |first11=Matthew N. |last12=Oghalai |first12=John S. |title=Mechanisms of hearing loss after blast injury to the ear |journal=PLOS ONE |date=1 July 2013 |volume=8 |issue=7 |pages=e67618 |doi=10.1371/journal.pone.0067618 |pmid=23840874 |pmc=3698122 |doi-access=free }}

In 2018, Oghalai and colleagues studied molecular dimensions of noise-induced hearing loss in mice by using optical coherence tomography, an imaging technique that allows in vivo (instead of invasive) observation and measurement. They found that after blasts damage hair cells, there is also a build up of ionized potassium in cochlear fluid. The findings showed how high concentrations of potassium disrupts hair and nerve cells, whose degeneration or synaptopathy contributes to hearing loss.{{cite journal |last1=Zhao |first1=H |last2=Zhu |first2=Y |last3=Liu |first3=L |title=Excess extracellular K+ causes inner hair cell ribbon synapse degeneration |journal=Communications Biology |date=2021 |volume=4 |issue=1 |page=24 |doi=10.1038/s42003-020-01532-w|pmid=33398038 |pmc=7782724 }}{{cite news |last1=Houser |first1=Kristin |title=An Injection Of Salt In Your Eardrum Might Save You From A Lifetime Of Hearing Loss |url=https://futurism.com/neoscope/nihl-hearing-treatment-salt-eardrum |access-date=13 January 2023 |work=Futurism |date=14 May 2018}}{{cite journal |last1=Kim |first1=J |last2=Xia |first2=A |last3=Grillet |first3=N |last4=Applegate |first4=B.E. |last5=Oghalai |first5=J.S. |title=Osmotic stabilization prevents cochlear synaptopathy after blast trauma |journal=Proceedings of the National Academy of Sciences |date=2018 |volume=115 |issue=21 |pages=E4853–E4860 |doi=10.1073/pnas.1720121115 |pmid=29735658 |pmc=6003510 |doi-access=free }}

In 2022 Oghalai and colleagues published results for a longitudinal study on the effects of cochlear implants on deaf children with developmental delays. They compared cohorts of children who received the implants to a cohort of children who, due to insurance protocols, were only given hearing aids. The children who received implants showed improved cognitive and behavioral functioning.{{cite news |last1=Black |first1=Lisa |title=Study Finds Benefits for Deaf Children With Developmental Delays Who Receive Cochlear Implants |url=https://www.aap.org/en/news-room/news-releases/pediatrics2/2022/study-finds-benefits-for-deaf-children-with-developmental-delays-who-receive-cochlear-implants/ |access-date=23 January 2023 |work=AAP News |publisher=American Academy of Pediatrics |date=24 May 2022}}{{cite news |last1=Katie |first1=Hobbins |title=Cochlear implants benefit children with hearing loss and developmental delays, says study |url=https://www.contemporarypediatrics.com/view/cochlear-implants-benefit-children-with-hearing-loss-developmental-delays |access-date=18 January 2023 |work=Contemporary Pediatrics |date=25 May 2022}}

{{cite journal |last1=Oghalai |first1=JS |last2=Bortfeld |first2=H |last3=Feldman |first3=HM |last4=Chimalakonda |first4=N |last5=Emery |first5=C |last6=Choi |first6=JS |last7=Zhou |first7=S |title=Cochlear implants for deaf children with early developmental impairment |journal=Pediatrics |date=2022 |volume=149 |issue=6 |doi=10.1542/peds.2021-055459|pmid=35607935 |pmc=9648123 }}

John Oghalai is married to Tracy Nguyen-Oghalai, a rheumatologist. They have two sons, Kevin{{cite news |last1=Dong |first1=Jocelyn |title=Small wonders: using books, front yards to foster neighborliness |url=https://www.paloaltoonline.com/news/2013/03/24/small-wonders-using-books-front-yards-to-foster-neighborliness |access-date=19 January 2023 |work=Palo Alto Weekly |date=23 March 2013}} and Tom.

• {{cite journal |last1=Oghalai |first1=JS |last2=Manolidis |first2=S |last3=Barth |first3=JL |last4=Stewart |first4=MG |last5=Jenkins |first5=HA |title=Unrecognized Benign Paroxysmal Positional Vertigo in Elderly Patients |journal=Otolaryngology–Head and Neck Surgery |date=2000 |volume=122 |issue=5 |pages=630–634 |doi=10.1016/S0194-5998(00)70187-2|pmid=10793337 |s2cid=33401924 }}
• {{cite journal |last1=Oghalai |first1=JS |last2=Zhao |first2=HB |last3=Kutz |first3=JW |last4=Brownell |first4=WE |title=Voltage- and tension-dependent lipid mobility in the outer hair cell plasma membrane |journal=Science |date=2000 |volume=287 |issue=5453 |pages=658–61 |doi=10.1126/science.287.5453.658|pmid=10650000 |pmc=1976274 }}
• {{cite journal |last1=Chai |first1=R |last2=Wang |first2=T |last3=Liaw |first3=EJ |last4=Xia |first4=A |last5=Jan |first5=TA |last6=Liu |first6=Z |last7=Taketo |first7=MM |last8=Oghalai |first8=JS |last9=Nusse |first9=R |last10=Zuo |first10=J |last11=Cheng |first11=AG |title=Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. |journal=Proc Natl Acad Sci U S A |date=22 May 2012 |volume=109 |issue=22 |pages=8167–72 |doi=10.1073/pnas.1202774109 |pmid=22562792 |pmc=3361451 |doi-access=free }}
• {{cite journal |last1=Lee |first1=HY |last2=Raphael |first2=PD |last3=Park |first3=J |last4=Ellerbee |first4=AK |last5=Applegate |first5=BE |last6=Oghalai |first6=JS |title=Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea |journal=Proc Natl Acad Sci U S A |date=10 March 2015 |volume=112 |issue=10 |pages=3128–33 |doi=10.1073/pnas.1500038112 |pmid=25737536 |pmc=4364183 |doi-access=free }}

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Category:1968 births

Category:Living people

Category:American otolaryngologists

Category:University of Wisconsin–Madison alumni

Category:Keck School of Medicine of USC faculty