Jonathan Weissman
{{short description|American scientist and academic}}
{{Infobox scientist
| name = Jonathan S. Weissman
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| nationality = American
| fields = Biochemistry
| workplaces = MIT
| alma_mater = Harvard University, MIT, Yale University
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| doctoral_advisor = Peter Kim
| academic_advisors = Arthur Horwich
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| known_for = Ribosome profiling
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|prizes = {{Plainlist|
- Protein Society Irving Sigal Young Investigator Award (2004)
- Raymond and Beverly Sackler International Prize (2008)
- National Academy of Sciences Award for Scientific Discovery (2015)}}
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Jonathan S. Weissman is the Landon T. Clay Professor of Biology at the Massachusetts Institute of Technology, a member of the Whitehead Institute, and a Howard Hughes Medical Institute Investigator. From 1996 to 2020, he was a faculty member in the department of cellular molecular pharmacology at the University of California, San Francisco.
Education
He earned his B.A. in physics from Harvard College (1988) and his Ph.D. in physics (1993) from MIT working with Peter Kim. There, he started his studies on protein folding examining Bovine pancreatic trypsin inhibitor (BPTI).{{cite journal|last=Hoffman|first=M|title=Straightening out the protein folding puzzle.|journal=Science|date=Sep 20, 1991|volume=253|issue=5026|pages=1357–8|pmid=1896845|doi=10.1126/science.1896845|bibcode=1991Sci...253.1357H|s2cid=38632703}}
He was a postdoctoral fellow at Yale University (1993–1996), where he worked with Arthur Horwich studying the mechanism of GroEL.{{cite journal|last=Weissman|first=JS|author2=Hohl, CM |author3=Kovalenko, O |author4=Kashi, Y |author5=Chen, S |author6=Braig, K |author7=Saibil, HR |author8=Fenton, WA |author9= Horwich, AL |title=Mechanism of GroEL action: productive release of polypeptide from a sequestered position under GroES.|journal=Cell|date=Nov 17, 1995|volume=83|issue=4|pages=577–87|pmid=7585961|doi=10.1016/0092-8674(95)90098-5|s2cid=17839893|doi-access=free}}{{cite journal|last=Weissman|first=Jonathan S.|author2=O'Shea, Erin K.|title=2004 Irving Sigal Young Investigator Award|journal=Protein Science|date=1 January 2009|volume=13|issue=12|pages=3333–3335|doi=10.1110/ps.041134604|pmid=15557272|pmc=2287319}}
Career
Weissman's research team studies how cells ensure that proteins fold into their correct shape, as well as the role of protein misfolding in disease and normal physiology. The team also develops experimental and analytical approaches for exploring the organizational principles of biological systems and globally monitoring protein translation through ribosome profiling. A broad goal of his work is to bridge large-scale approaches and in depth mechanistic investigations to reveal the information encoded within genomes.{{cite news|title=New Technique Focuses on Transcription|url=http://www.hhmi.org/news/weissman20110120.html|accessdate=14 February 2013|newspaper=HHMI|date=20 January 2011}}{{cite journal|last=Ingolia|first=Nicholas T.|author2=Lareau, Liana F. |author3=Weissman, Jonathan S. |title=Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes|journal=Cell|date=1 November 2011|volume=147|issue=4|pages=789–802|doi=10.1016/j.cell.2011.10.002|pmid=22056041|pmc=3225288}}{{cite web|title=Jonathan S. Weissman|url=http://www.hhmi.org/research/investigators/weissman_bio.html|publisher=HHMI|accessdate=14 February 2013}}
Weissman has been a member of the National Academy of Sciences since 2009. in 2015, he co-founded the Innovative Genomics Institute with Jennifer Doudna.
Weissman joined the Whitehead Institute and MIT in March 2020.{{cite web |last=Trafton |first=Anne |title=Pioneering cell researcher Jonathan Weissman joins Whitehead Institute, MIT |url=https://news.mit.edu/2020/pioneering-cell-researcher-jonathan-weissman-joins-whitehead-institute-mit-0316 |website=MIT News |date=2020-03-16 |publisher=Massachusetts Institute of Technology |access-date=2025-05-15}}
References
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External links
- [http://profiles.ucsf.edu/jonathan.weissman UCSF Academic Bio]
- [http://www.hhmi.org/research/investigators/weissman_bio.html His Howard Hughes Medical Institute bio]
- [http://weissmanlab.ucsf.edu/people/jonathan.html Weissman Lab website]
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Category:Howard Hughes Medical Investigators
Category:Place of birth missing (living people)
Category:Year of birth missing (living people)
Category:University of California, San Francisco faculty
Category:Members of the United States National Academy of Sciences
Category:Harvard College alumni
Category:Massachusetts Institute of Technology School of Science alumni