Julie Ahringer

{{Short description|American geneticist}}

{{Infobox scientist

| name = Julie Ahringer

| honorific_suffix = {{post-nominals|country=GBR|FMedSci|FRS|size=100}}

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| image = Julie Ahringer (16464845320).jpg

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| caption = Ahringer in 2014

| birth_name = Julie Ann Ahringer

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| nationality = American

| fields = {{Plainlist|

• Chromatin
• Epigenetics
• Gene expression
• Genome organization}}

| workplaces = Gurdon Institute
University of Cambridge
Laboratory of Molecular Biology
University of Wisconsin–Madison

| alma_mater = {{Plainlist|

• Lafayette College (BA)
• University of Wisconsin–Madison (PhD)}}

| thesis_title = Post-transcriptional regulation of fem-3, a sex-determining gene of Caenorhabditis elegans

| thesis_url = https://www.proquest.com/docview/303972449

| thesis_year = 1991

| doctoral_advisor = Judith Kimble

| academic_advisors = John Graham White

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| known_for = RNA interference{{Cite journal | last1 = Qu | first1 = W. | last2 = Ren | first2 = C. | last3 = Li | first3 = Y. | last4 = Shi | first4 = J. | last5 = Zhang | first5 = J. | last6 = Wang | first6 = X. | last7 = Hang | first7 = X. | last8 = Lu | first8 = Y. | last9 = Zhao | first9 = D. | last10 = Zhang | first10 = C. | title = Reliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: A guide for genome-wide screens | doi = 10.1186/1471-2164-12-170 | journal = BMC Genomics | volume = 12 | page = 170 | year = 2011 | pmid = 21453524| pmc =3087708 | doi-access = free }}
Caenorhabditis elegans{{Cite journal | first8 = N.| last9 = Moreno| last8 = Le Bot | first7 = A.| last7 = Kanapin | first9 = S. | last10 = Sohrmann | first10 = M. | last11 = Welchman | first11 = D. P. | last12 = Zipperlen | first12 = P. | last13 = Ahringer | first13 = J.| title = Systematic functional analysis of the Caenorhabditis elegans genome using RNAi| journal = Nature| pages = 231–237| issue = 6920| volume = 421 | first6 = M.| last6 = Gotta | first1 = R.| last2 = Fraser| last1 = Kamath| year = 2003| pmid = 12529635 | first2 = A.| last3 = Dong| last5 = Durbin | first5 = R. | first4 = G.| last4 = Poulin | first3 = Y.| doi = 10.1038/nature01278 | bibcode = 2003Natur.421..231K| s2cid = 15745225}}{{Cite journal | last1 = Ahringer | first1 = J. | author-link1 = Julie Ahringer| last2 = Kamath | first2 = A. G. | last3 = Zipperlen | first3 = R. S. | last4 = Martinez-Campos | first4 = P. | last5 = Sohrmann | first5 = M. | last6 = Ahringer | first6 = M. | title = Functional genomic analysis of C. Elegans chromosome I by systematic RNA interference | journal = Nature | volume = 408 | issue = 6810 | pages = 325–330 | year = 2000 | doi = 10.1038/35042517 | pmid = 11099033| bibcode = 2000Natur.408..325F | s2cid = 4373444 }}{{Cite journal | last1 = Murphy | first1 = C. T. | last2 = McCarroll | first2 = S. A. | last3 = Bargmann | first3 = C. I. | last4 = Fraser | first4 = A. | last5 = Kamath | first5 = R. S. | last6 = Ahringer | first6 = J. | last7 = Li | first7 = H. | last8 = Kenyon | first8 = C. | doi = 10.1038/nature01789 | title = Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans | journal = Nature | volume = 424 | issue = 6946 | pages = 277–283 | year = 2003 | pmid = 12845331| bibcode = 2003Natur.424..277M | s2cid = 4424249 }}{{Cite journal | last1 = Ashrafi | first1 = K. | last2 = Chang | first2 = F. Y. | last3 = Watts | first3 = J. L. | last4 = Fraser | first4 = A. G. | last5 = Kamath | first5 = R. S. | last6 = Ahringer | first6 = J. | last7 = Ruvkun | first7 = G. | doi = 10.1038/nature01279 | title = Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes | journal = Nature | volume = 421 | issue = 6920 | pages = 268–272 | year = 2003 | pmid = 12529643| bibcode = 2003Natur.421..268A | s2cid = 4321264 }}{{Cite journal | last1 = Lee | first1 = S. S. | last2 = Lee | first2 = R. Y. N. | last3 = Fraser | first3 = A. G. | last4 = Kamath | first4 = R. S. | last5 = Ahringer | first5 = J. | last6 = Ruvkun | first6 = G. | doi = 10.1038/ng1056 | title = A systematic RNAi screen identifies a critical role for mitochondria in C. Elegans longevity | journal = Nature Genetics | volume = 33 | issue = 1 | pages = 40–48 | year = 2002 | pmid = 12447374| s2cid = 17681940 }}

| influences =

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• EMBO Member (2003)
• Crick Lecture (2004)
• George W. Beadle Award (2020)}}

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| spouse = {{marriage|Richard Durbin|1996}}

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Julie Ann Ahringer {{post-nominals|country=GBR|FMedSci|FRS}} is an American/British Professor of Genetics and Genomics, Director of the Gurdon Institute and a member of the Department of Genetics at the University of Cambridge.{{cite web|url=http://www2.gurdon.cam.ac.uk/~ahringerlab/|title=Home | Ahringer Lab|author=Florence Leroy based on Custom Repute template|website=Gurdon.cam.ac.uk|archive-url=https://web.archive.org/web/20161017074039/http://www2.gurdon.cam.ac.uk/~ahringerlab/|archive-date=2016-10-17|url-status=dead|access-date=2016-12-19}}{{Scopus|id=7004726748}}{{Google scholar id}}{{EuropePMC}}{{Cite journal | last1 = Pocock | first1 = R. | last2 = Ahringer | first2 = J. | author-link2 = Julie Ahringer| last3 = Mitsch | first3 = M. | last4 = Maxwell | first4 = S. | last5 = Woollard | first5 = A. | author-link5 = Alison Woollard| title = A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. Elegans | doi = 10.1242/dev.01110 | journal = Development | volume = 131 | issue = 10 | pages = 2373–2385 | year = 2004 | pmid = 15102704 | doi-access = free }} She leads a research lab investigating the control of gene expression.

Her laboratory carried out the first systematic inactivation of the majority of genes in an animal through constructing and screening a genome-wide RNA interference library for the nematode worm Caenorhabditis elegans.{{Cite web|url=https://nccr-chembio.ch/events/outstanding-women-science-seminar-series-julie-ahringer/|title=Outstanding Women In Science Seminar series: Julie Ahringer|website=NCCR in Chemical Biology|language=en-US|access-date=2019-04-06}} Research in Ahringer's lab investigates the control of gene expression and genome architecture in development, using C. elegans as a model system.{{Cite web|url=http://ahringer.group.gurdon.cam.ac.uk/|title=Ahringer Lab — The Gurdon Institute|website=www.ahringer.group.gurdon.cam.ac.uk/|language=en|access-date=2020-12-10}}