KCNA5

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Mutations in this gene have been related to both atrial fibrillation{{cite journal | vauthors = Olson TM, Alekseev AE, Liu XK, Park S, Zingman LV, Bienengraeber M, Sattiraju S, Ballew JD, Jahangir A, Terzic A | title = Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation | journal = Human Molecular Genetics | volume = 15 | issue = 14 | pages = 2185–2191 | date = July 2006 | pmid = 16772329 | doi = 10.1093/hmg/ddl143 | doi-access =free }} and sudden cardiac death.{{cite journal | vauthors = Nielsen NH, Winkel BG, Kanters JK, Schmitt N, Hofman-Bang J, Jensen HS, Bentzen BH, Sigurd B, Larsen LA, Andersen PS, Haunsø S, Kjeldsen K, Grunnet M, Christiansen M, Olesen SP | title = Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients | journal = Biochemical and Biophysical Research Communications | volume = 354 | issue = 3 | pages = 776–782 | date = March 2007 | pmid = 17266934 | doi = 10.1016/j.bbrc.2007.01.048 }} KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.

KCNA5 has been shown to interact with DLG4,{{cite journal | vauthors = Eldstrom J, Choi WS, Steele DF, Fedida D | title = SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism | journal = FEBS Letters | volume = 547 | issue = 1–3 | pages = 205–211 | date = July 2003 | pmid = 12860415 | doi = 10.1016/S0014-5793(03)00668-9 | s2cid = 34857270 | doi-access = | bibcode = 2003FEBSL.547..205E }}{{cite journal | vauthors = Eldstrom J, Doerksen KW, Steele DF, Fedida D | title = N-terminal PDZ-binding domain in Kv1 potassium channels | journal = FEBS Letters | volume = 531 | issue = 3 | pages = 529–537 | date = November 2002 | pmid = 12435606 | doi = 10.1016/S0014-5793(02)03572-X | s2cid = 40689829 | doi-access = | bibcode = 2002FEBSL.531..529E }} PDZ domain-containing proteins such as SAP97,{{cite journal | vauthors = Murata M, Buckett PD, Zhou J, Brunner M, Folco E, Koren G | title = SAP97 interacts with Kv1.5 in heterologous expression systems | journal = American Journal of Physiology. Heart and Circulatory Physiology | volume = 281 | issue = 6 | pages = H2575–H2584 | date = December 2001 | pmid = 11709425 | doi = 10.1152/ajpheart.2001.281.6.H2575 | s2cid = 28915450 | doi-access = free }} and Actinin, alpha 2.{{cite journal | vauthors = Maruoka ND, Steele DF, Au BP, Dan P, Zhang X, Moore ED, Fedida D | title = alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells | journal = FEBS Letters | volume = 473 | issue = 2 | pages = 188–194 | date = May 2000 | pmid = 10812072 | doi = 10.1016/S0014-5793(00)01521-0 | s2cid = 13026110 | doi-access = free | bibcode = 2000FEBSL.473..188M }}

• Voltage-gated potassium channel

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X | title = International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 473–508 | date = December 2005 | pmid = 16382104 | doi = 10.1124/pr.57.4.10 | s2cid = 219195192 }}
• {{cite journal | vauthors = Curran ME, Landes GM, Keating MT | title = Molecular cloning, characterization, and genomic localization of a human potassium channel gene | journal = Genomics | volume = 12 | issue = 4 | pages = 729–737 | date = April 1992 | pmid = 1349297 | doi = 10.1016/0888-7543(92)90302-9 }}
• {{cite journal | vauthors = Philipson LH, Hice RE, Schaefer K, LaMendola J, Bell GI, Nelson DJ, Steiner DF | title = Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 1 | pages = 53–57 | date = January 1991 | pmid = 1986382 | pmc = 50746 | doi = 10.1073/pnas.88.1.53 | doi-access = free | bibcode = 1991PNAS...88...53P }}
• {{cite journal | vauthors = Tamkun MM, Knoth KM, Walbridge JA, Kroemer H, Roden DM, Glover DM | title = Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle | journal = FASEB Journal | volume = 5 | issue = 3 | pages = 331–337 | date = March 1991 | pmid = 2001794 | doi = 10.1096/fasebj.5.3.2001794 | s2cid = 23737559 | doi-access = free }}
• {{cite journal | vauthors = Mays DJ, Foose JM, Philipson LH, Tamkun MM | title = Localization of the Kv1.5 K+ channel protein in explanted cardiac tissue | journal = The Journal of Clinical Investigation | volume = 96 | issue = 1 | pages = 282–292 | date = July 1995 | pmid = 7615797 | pmc = 185199 | doi = 10.1172/JCI118032 }}
• {{cite journal | vauthors = Crumb WJ, Wible B, Arnold DJ, Payne JP, Brown AM | title = Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine-associated cardiotoxicity | journal = Molecular Pharmacology | volume = 47 | issue = 1 | pages = 181–190 | date = January 1995 | doi = 10.1016/S0026-895X(25)08517-7 | pmid = 7838127 }}
• {{cite journal | vauthors = Phromchotikul T, Browne DL, Curran ME, Keating MT, Litt M | title = Dinucleotide repeat polymorphism at the KCNA5 locus | journal = Human Molecular Genetics | volume = 2 | issue = 9 | pages = 1512 | date = September 1993 | pmid = 8242092 | doi = 10.1093/hmg/2.9.1512-a }}
• {{cite journal | vauthors = Albrecht B, Weber K, Pongs O | title = Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13 | journal = Receptors & Channels | volume = 3 | issue = 3 | pages = 213–220 | year = 1996 | pmid = 8821794 }}
• {{cite journal | vauthors = Holmes TC, Fadool DA, Ren R, Levitan IB | title = Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain | journal = Science | volume = 274 | issue = 5295 | pages = 2089–2091 | date = December 1996 | pmid = 8953041 | doi = 10.1126/science.274.5295.2089 | doi-access = | bibcode = 1996Sci...274.2089H }}
• {{cite journal | vauthors = Lacerda AE, Roy ML, Lewis EW, Rampe D | title = Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart | journal = Molecular Pharmacology | volume = 52 | issue = 2 | pages = 314–322 | date = August 1997 | pmid = 9271355 | doi = 10.1124/mol.52.2.314 }}
• {{cite journal | vauthors = Kääb S, Dixon J, Duc J, Ashen D, Näbauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, Tomaselli GF | title = Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density | journal = Circulation | volume = 98 | issue = 14 | pages = 1383–1393 | date = October 1998 | pmid = 9760292 | doi = 10.1161/01.cir.98.14.1383 | doi-access = free }}
• {{cite journal | vauthors = Maruoka ND, Steele DF, Au BP, Dan P, Zhang X, Moore ED, Fedida D | title = alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells | journal = FEBS Letters | volume = 473 | issue = 2 | pages = 188–194 | date = May 2000 | pmid = 10812072 | doi = 10.1016/S0014-5793(00)01521-0 | s2cid = 13026110 | doi-access = free | bibcode = 2000FEBSL.473..188M }}
• {{cite journal | vauthors = Peretz A, Gil-Henn H, Sobko A, Shinder V, Attali B, Elson A | title = Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon | journal = The EMBO Journal | volume = 19 | issue = 15 | pages = 4036–4045 | date = August 2000 | pmid = 10921884 | pmc = 306594 | doi = 10.1093/emboj/19.15.4036 }}
• {{cite journal | vauthors = Nitabach MN, Llamas DA, Araneda RC, Intile JL, Thompson IJ, Zhou YI, Holmes TC | title = A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 2 | pages = 705–710 | date = January 2001 | pmid = 11149959 | pmc = 14652 | doi = 10.1073/pnas.031446198 | doi-access = free }}
• {{cite journal | vauthors = Cukovic D, Lu GW, Wible B, Steele DF, Fedida D | title = A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of alpha-actinin-2 | journal = FEBS Letters | volume = 498 | issue = 1 | pages = 87–92 | date = June 2001 | pmid = 11389904 | doi = 10.1016/S0014-5793(01)02505-4 | s2cid = 20622483 | doi-access = free | bibcode = 2001FEBSL.498...87C }}
• {{cite journal | vauthors = Kurata HT, Soon GS, Eldstrom JR, Lu GW, Steele DF, Fedida D | title = Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels | journal = The Journal of Biological Chemistry | volume = 277 | issue = 32 | pages = 29045–29053 | date = August 2002 | pmid = 12021261 | doi = 10.1074/jbc.M111470200 | doi-access = free }}
• {{cite journal | vauthors = Williams CP, Hu N, Shen W, Mashburn AB, Murray KT | title = Modulation of the human Kv1.5 channel by protein kinase C activation: role of the Kvbeta1.2 subunit | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 302 | issue = 2 | pages = 545–550 | date = August 2002 | pmid = 12130714 | doi = 10.1124/jpet.102.033357 | s2cid = 34085749 }}
• {{cite journal | vauthors = Eldstrom J, Doerksen KW, Steele DF, Fedida D | title = N-terminal PDZ-binding domain in Kv1 potassium channels | journal = FEBS Letters | volume = 531 | issue = 3 | pages = 529–537 | date = November 2002 | pmid = 12435606 | doi = 10.1016/S0014-5793(02)03572-X | s2cid = 40689829 | doi-access = | bibcode = 2002FEBSL.531..529E }}
• {{cite journal | vauthors = Zhang S, Kurata HT, Kehl SJ, Fedida D | title = Rapid induction of P/C-type inactivation is the mechanism for acid-induced K+ current inhibition | journal = The Journal of General Physiology | volume = 121 | issue = 3 | pages = 215–225 | date = March 2003 | pmid = 12601085 | pmc = 2217332 | doi = 10.1085/jgp.20028760 }}

{{refend}}

• {{MeshName|Kv1.5+Potassium+Channel}}
• {{MeshName|KCNA5+protein,+human}}

{{Ion channels|g3}}

{{NLM content}}

Category:Ion channels

{{membrane-protein-stub}}