KCNC2
{{Short description|Protein-coding gene in humans}}
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{{Infobox_gene}}
Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene.{{cite journal |vauthors=Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B | title = Localization of Shaw-related K+ channel genes on mouse and human chromosomes | journal = Mamm Genome | volume = 4 | issue = 12 | pages = 711–5 |date=Mar 1994 | pmid = 8111118 | doi =10.1007/BF00357794 | s2cid = 24121259 }}{{cite journal |vauthors=Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X | title = International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels | journal = Pharmacol Rev | volume = 57 | issue = 4 | pages = 473–508 |date=Dec 2005 | pmid = 16382104 | doi = 10.1124/pr.57.4.10 | s2cid = 219195192 }} The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).{{cite journal |vauthors=Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X | title = International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels | journal = Pharmacol. Rev. | volume = 57 | issue = 4 | pages = 473–508 |date=December 2005 | pmid = 16382104 | doi = 10.1124/pr.57.4.10 | s2cid = 219195192 }}
Expression pattern
Kv3.1 and Kv3.2 channels are prominently expressed in neurons that fire at high frequency. Kv3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.{{cite web | url = http://ykolodin.50webs.com | title = Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat | author = Kolodin YO | date = 2008-04-27 | access-date = 2008-10-20}}{{cite journal |vauthors=Rudy B, McBain CJ | title = Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing | journal = Trends in Neurosciences | volume = 24 | issue = 9 | pages = 517–26 |date=September 2001 | pmid = 11506885 | doi = 10.1016/S0166-2236(00)01892-0 | s2cid = 36100588 }}
Physiological role
Kv3.1/Kv3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.{{cite journal |vauthors=Lien CC, Jonas P | title = Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons | journal = Journal of Neuroscience | volume = 23 | issue = 6 | pages = 2058–68 |date=March 2003 | pmid = 12657664 | doi = 10.1523/JNEUROSCI.23-06-02058.2003| pmc = 6742035 | doi-access = free }} Sometimes in heteromeric complexes with Kv3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.
Pharmacological properties
Kv3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC50 values are 0.1 mM for both of the drugs). This can be useful in identifying native channels.
Transcript variants
There are four transcript variants of Kv3.2 gene: Kv3.2a, Kv3.2b, Kv3.2c, Kv3.2d. Kv3.2 isoforms differ only in their C-terminal sequence.{{cite journal |vauthors=Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E | title = Contributions of Kv3 channels to neuronal excitability | journal = Annals of the New York Academy of Sciences | volume = 868 | issue = 1 MOLECULAR AND| pages = 304–43 |date=April 1999 | pmid = 10414303 | doi = 10.1111/j.1749-6632.1999.tb11295.x | s2cid = 25289187 | doi-access = free | bibcode = 1999NYASA.868..304R }}
References
{{Reflist|2}}
External links
- {{MeshName|Kv3.2+Potassium+Channel}}
- {{MeshName|KCNC2+protein,+human}}
{{Ion channels|g3}}
{{membrane-protein-stub}}