KCNJ3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
G protein-activated inward rectifier potassium channel 1 (GIRK-1) is encoded in the human by the gene KCNJ3.{{cite web | title = Entrez Gene: KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3760}}
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a hetero-tetrameric pore-forming complex.
Interactions
KCNJ3 has been shown to interact with KCNJ5.{{cite journal |last=Huang |first=C L |author2=Jan Y N |author3=Jan L Y |date=Apr 1997 |title=Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels |journal=FEBS Lett. |volume=405 |issue=3 |pages=291–8 | issn = 0014-5793| pmid = 9108307 |doi=10.1016/S0014-5793(97)00197-X |s2cid=44072628 |doi-access= |bibcode=1997FEBSL.405..291H }}{{cite journal |last=He |first=Cheng |author2=Yan Xixin |author3=Zhang Hailin |author4=Mirshahi Tooraj |author5=Jin Taihao |author6=Huang Aijun |author7=Logothetis Diomedes E |date=Feb 2002 |title=Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins |journal=J. Biol. Chem. |volume=277 |issue=8 |pages=6088–96 | issn = 0021-9258| pmid = 11741896 |doi = 10.1074/jbc.M104851200 |doi-access=free }}
See also
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Kubo Y, Adelman JP, Clapham DE, etal |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509–26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11 |s2cid=11588492 }}
- {{cite journal |vauthors=Stoffel M, Espinosa R, Powell KL, etal |title=Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism |journal=Genomics |volume=21 |issue= 1 |pages= 254–6 |year= 1994 |pmid= 8088798 |doi= 10.1006/geno.1994.1253 }}
- {{cite journal |vauthors=Schoots O, Yue KT, MacDonald JF, etal |title=Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum |journal=Brain Res. Mol. Brain Res. |volume=39 |issue= 1–2 |pages= 23–30 |year= 1996 |pmid= 8804710 |doi=10.1016/0169-328X(95)00349-W }}
- {{cite journal |vauthors=Chan KW, Langan MN, Sui JL, etal |title=A recombinant inwardly rectifying potassium channel coupled to GTP- binding proteins |journal=J. Gen. Physiol. |volume=107 |issue= 3 |pages= 381–97 |year= 1996 |pmid= 8868049 |doi=10.1085/jgp.107.3.381 | pmc=2216996 }}
- {{cite journal |vauthors=Liao YJ, Jan YN, Jan LY |title=Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain |journal=J. Neurosci. |volume=16 |issue= 22 |pages= 7137–50 |year= 1996 |pmid= 8929423 |doi= 10.1523/JNEUROSCI.16-22-07137.1996|pmc=6578936 |doi-access=free }}
- {{cite journal |vauthors=Signorini S, Liao YJ, Duncan SA, etal |title=Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 3 |pages= 923–7 |year= 1997 |pmid= 9023358 |doi=10.1073/pnas.94.3.923 | pmc=19615 |bibcode=1997PNAS...94..923S |doi-access=free }}
- {{cite journal |vauthors=Huang CL, Jan YN, Jan LY |title=Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels |journal=FEBS Lett. |volume=405 |issue= 3 |pages= 291–8 |year= 1997 |pmid= 9108307 |doi=10.1016/S0014-5793(97)00197-X |s2cid=44072628 |doi-access= |bibcode=1997FEBSL.405..291H }}
- {{cite journal |vauthors=Schoots O, Voskoglou T, Van Tol HH |title=Genomic organization and promoter analysis of the human G-protein-coupled K+ channel Kir3.1 (KCNJ3/HGIRK1) |journal=Genomics |volume=39 |issue= 3 |pages= 279–88 |year= 1997 |pmid= 9119365 |doi= 10.1006/geno.1996.4495 }}
- {{cite journal |vauthors=Corey S, Clapham DE |title=Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27499–504 |year= 1998 |pmid= 9765280 |doi=10.1074/jbc.273.42.27499 |doi-access=free }}
- {{cite journal |vauthors=Kennedy ME, Nemec J, Corey S, etal |title=GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels |journal=J. Biol. Chem. |volume=274 |issue= 4 |pages= 2571–82 |year= 1999 |pmid= 9891030 |doi=10.1074/jbc.274.4.2571 |doi-access=free }}
- {{cite journal |vauthors=Pabon A, Chan KW, Sui JL, etal |title=Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30677–82 |year= 2000 |pmid= 10889209 |doi= 10.1074/jbc.M005338200 |doi-access= free }}
- {{cite journal |vauthors=He C, Yan X, Zhang H, etal |title=Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6088–96 |year= 2002 |pmid= 11741896 |doi= 10.1074/jbc.M104851200 |doi-access= free }}
- {{cite journal |vauthors=Chen L, Kawano T, Bajic S, etal |title=A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: Implication for Andersen's syndrome |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 8430–5 |year= 2002 |pmid= 12034888 |doi= 10.1073/pnas.122682899 | pmc=123084 |bibcode=2002PNAS...99.8430C |doi-access=free }}
- {{cite journal |vauthors=Lavine N, Ethier N, Oak JN, etal |title=G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46010–9 |year= 2003 |pmid= 12297500 |doi= 10.1074/jbc.M205035200 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Ivanina T, Rishal I, Varon D, etal |title=Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29174–83 |year= 2003 |pmid= 12743112 |doi= 10.1074/jbc.M304518200 |doi-access= free }}
- {{cite journal |vauthors=Shankar H, Murugappan S, Kim S, etal |title=Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses |journal=Blood |volume=104 |issue= 5 |pages= 1335–43 |year= 2004 |pmid= 15142872 |doi= 10.1182/blood-2004-01-0069 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Plummer HK, Dhar MS, Cekanova M, Schuller HM |title=Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines |journal=BMC Cancer |volume=5|pages= 104 |year= 2006 |pmid= 16109170 |doi= 10.1186/1471-2407-5-104 | pmc=1208863 |doi-access=free }}
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External links
- {{MeshName|KCNJ3+protein,+human}}
{{NLM content}}
{{PDB Gallery|geneid=3760}}
{{Ion channels|g3}}
{{membrane-protein-stub}}