KCNK7
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which is encoded in humans by the KCNK7 gene. K2P7.1 is a potassium channel containing two pore-forming P domains.{{cite journal |vauthors=Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M | title = Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure | journal = J. Biol. Chem. | volume = 274 | issue = 17 | pages = 11751–60 |date=April 1999 | pmid = 10206991 | doi = 10.1074/jbc.274.17.11751 | doi-access = free }}{{cite journal |vauthors=Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N | title = Potassium leak channels and the KCNK family of two-P-domain subunits | journal = Nat. Rev. Neurosci. | volume = 2 | issue = 3 | pages = 175–84 |date=March 2001 | pmid = 11256078 | doi = 10.1038/35058574| s2cid = 9682396 | url = https://escholarship.org/uc/item/9z7112ns}}{{cite journal |vauthors=Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S | title = International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels | journal = Pharmacol. Rev. | volume = 57 | issue = 4 | pages = 527–40 |date=December 2005 | pmid = 16382106 | doi = 10.1124/pr.57.4.12 | s2cid = 7356601 | url = https://escholarship.org/uc/item/3k15p5vt}} Multiple transcript variants encoding different isoforms have been found for this gene.
Function
This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.{{cite web | title = Entrez Gene: potassium channel| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10089}}
See also
References
{{Reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |name-list-style=vanc|author2=Feingold EA |author3=Grouse LH |display-authors=3 |last4=Derge |first4=JG |last5=Klausner |first5=RD |last6=Collins |first6=FS |last7=Wagner |first7=L |last8=Shenmen |first8=CM |last9=Schuler |first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N |title=Potassium leak channels and the KCNK family of two-P-domain subunits |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 175–84 |year= 2001 |pmid= 11256078 |doi=10.1038/35058574 |s2cid=9682396 |url=https://escholarship.org/uc/item/9z7112ns }}
- {{cite journal |author=Salinas M |title=Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11751–60 |year= 1999 |pmid= 10206991 |doi=10.1074/jbc.274.17.11751 |name-list-style=vanc|author2=Reyes R |author3=Lesage F |display-authors=3 |last4=Fosset |first4=M |last5=Heurteaux |first5=C |last6=Romey |first6=G |last7=Lazdunski |first7=M |doi-access=free }}
- {{cite journal |author=Medhurst AD |title=Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery |journal=Brain Res. Mol. Brain Res. |volume=86 |issue= 1–2 |pages= 101–14 |year= 2001 |pmid= 11165377 |doi=10.1016/S0169-328X(00)00263-1 |name-list-style=vanc|author2=Rennie G |author3=Chapman CG |display-authors=3 |last4=Meadows |first4=H |last5=Duckworth |first5=MD |last6=Kelsell |first6=RE |last7=Gloger |first7=II |last8=Pangalos |first8=MN }}
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External links
- {{MeshName|KCNK7+protein,+human}}
- {{UCSC genome browser|KCNK7}}
- {{UCSC gene details|KCNK7}}
{{Ion channels|g3}}
{{membrane-protein-stub}}