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KCNMB1

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox_gene}}

Calcium-activated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNMB1 gene.{{cite journal | vauthors = Tseng-Crank J, Godinot N, Johansen TE, Ahring PK, Strøbaek D, Mertz R, Foster CD, Olesen SP, Reinhart PH | title = Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 17 | pages = 9200–9205 | date = Aug 1996 | pmid = 8799178 | pmc = 38619 | doi = 10.1073/pnas.93.17.9200 | bibcode = 1996PNAS...93.9200T | doi-access = free }}{{cite journal | vauthors = Jiang Z, Wallner M, Meera P, Toro L | title = Human and rodent MaxiK channel beta-subunit genes: cloning and characterization | journal = Genomics | volume = 55 | issue = 1 | pages = 57–67 | date = Jan 1999 | pmid = 9888999 | doi = 10.1006/geno.1998.5627 }}{{cite web | title = Entrez Gene: KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3779 }}

Function

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Beta subunits (beta 1-4) are highly tissue specific in their expression, with beta-1 being present predominantly on vascular smooth muscle. Endothelial cells are not known to express beta-1 subunits. Beta-1 is also known to be expressed in urinary bladder and in some regions of the brain. Association of the beta-1 subunit with the BK channel increases the apparent Ca2+ sensitivity of the channel and decreases voltage dependence.{{cite journal | vauthors = Tano JY, Gollasch M | title = Hypoxia and ischemia-reperfusion: a BiK contribution? | journal = American Journal of Physiology. Heart and Circulatory Physiology | volume = 307 | issue = 6 | pages = H811–H817 | date = Sep 2014 | pmid = 25015960 | doi = 10.1152/ajpheart.00319.2014 | issn = 0363-6135 }}

See also

References

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Further reading

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  • {{cite journal | vauthors = Orio P, Rojas P, Ferreira G, Latorre R | title = New disguises for an old channel: MaxiK channel beta-subunits | journal = News in Physiological Sciences | volume = 17 | issue = 4 | pages = 156–161 | date = Aug 2002 | pmid = 12136044 | doi = 10.1152/nips.01387.2002 | hdl = 10533/173696 | hdl-access = free }}
  • {{cite journal | vauthors = Knaus HG, Folander K, Garcia-Calvo M, Garcia ML, Kaczorowski GJ, Smith M, Swanson R | title = Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle | journal = The Journal of Biological Chemistry | volume = 269 | issue = 25 | pages = 17274–17278 | date = Jun 1994 | pmid = 8006036 | doi = 10.1016/S0021-9258(17)32551-6 | doi-access = free }}
  • {{cite journal | vauthors = Meera P, Wallner M, Jiang Z, Toro L | title = A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels | journal = FEBS Letters | volume = 382 | issue = 1–2 | pages = 84–88 | date = Mar 1996 | pmid = 8612769 | doi = 10.1016/0014-5793(96)00151-2 | s2cid = 81684849 | bibcode = 1996FEBSL.382...84M }}
  • {{cite journal | vauthors = Dworetzky SI, Boissard CG, Lum-Ragan JT, McKay MC, Post-Munson DJ, Trojnacki JT, Chang CP, Gribkoff VK | title = Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation | journal = The Journal of Neuroscience | volume = 16 | issue = 15 | pages = 4543–4550 | date = Aug 1996 | pmid = 8764643 | pmc = 6579031 | doi = 10.1523/JNEUROSCI.16-15-04543.1996 }}
  • {{cite journal | vauthors = Valverde MA, Rojas P, Amigo J, Cosmelli D, Orio P, Bahamonde MI, Mann GE, Vergara C, Latorre R | title = Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit | journal = Science | location = New York, N.Y. | volume = 285 | issue = 5435 | pages = 1929–1931 | date = Sep 1999 | pmid = 10489376 | doi = 10.1126/science.285.5435.1929 }}
  • {{cite journal | vauthors = Meera P, Wallner M, Toro L | title = A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 10 | pages = 5562–5567 | date = May 2000 | pmid = 10792058 | pmc = 25868 | doi = 10.1073/pnas.100118597 | bibcode = 2000PNAS...97.5562M | doi-access = free }}
  • {{cite journal | vauthors = Jin P, Weiger TM, Wu Y, Levitan IB | title = Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit | journal = The Journal of Biological Chemistry | volume = 277 | issue = 12 | pages = 10014–10020 | date = Mar 2002 | pmid = 11790768 | doi = 10.1074/jbc.M107682200 | doi-access = free }}
  • {{cite journal | vauthors = Greenwood IA, Miller LJ, Ohya S, Horowitz B | title = The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 25 | pages = 22119–22122 | date = Jun 2002 | pmid = 11994272 | doi = 10.1074/jbc.C200215200 | doi-access = free }}
  • {{cite journal | vauthors = Gollasch M, Tank J, Luft FC, Jordan J, Maass P, Krasko C, Sharma AM, Busjahn A, Bähring S | title = The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation | journal = Journal of Hypertension | volume = 20 | issue = 5 | pages = 927–933 | date = May 2002 | pmid = 12011654 | doi = 10.1097/00004872-200205000-00028 | s2cid = 88440283 }}
  • {{cite journal | vauthors = Jin P, Weiger TM, Levitan IB | title = Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels | journal = The Journal of Biological Chemistry | volume = 277 | issue = 46 | pages = 43724–43729 | date = Nov 2002 | pmid = 12223479 | doi = 10.1074/jbc.M205795200 | doi-access = free }}
  • {{cite journal | vauthors = Mazzone JN, Kaiser RA, Buxton IL | title = Calcium-activated potassium channel expression in human myometrium: effect of pregnancy | journal = Proceedings of the Western Pharmacology Society | volume = 45 | pages = 184–186 | year = 2003 | pmid = 12434576 }}
  • {{cite journal | vauthors = Kudlacek PE, Pluznick JL, Ma R, Padanilam B, Sansom SC | title = Role of hbeta1 in activation of human mesangial BK channels by cGMP kinase | journal = American Journal of Physiology. Renal Physiology | volume = 285 | issue = 2 | pages = F289–F294 | date = Aug 2003 | pmid = 12670831 | doi = 10.1152/ajprenal.00046.2003 | s2cid = 3238002 }}
  • {{cite journal | vauthors = Qian X, Magleby KL | title = Beta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanisms | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 17 | pages = 10061–10066 | date = Aug 2003 | pmid = 12893878 | pmc = 187764 | doi = 10.1073/pnas.1731650100 | bibcode = 2003PNAS..10010061Q | doi-access = free }}
  • {{cite journal | vauthors = Ransom CB, Liu X, Sontheimer H | title = Current transients associated with BK channels in human glioma cells | journal = The Journal of Membrane Biology | volume = 193 | issue = 3 | pages = 201–213 | date = Jun 2003 | pmid = 12962281 | doi = 10.1007/s00232-003-2019-7 | s2cid = 20169684 }}
  • {{cite journal | vauthors = Hartness ME, Brazier SP, Peers C, Bateson AN, Ashford ML, Kemp PJ | title = Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia | journal = The Journal of Biological Chemistry | volume = 278 | issue = 51 | pages = 51422–51432 | date = Dec 2003 | pmid = 14522958 | doi = 10.1074/jbc.M309463200 | doi-access = free }}
  • {{cite journal | vauthors = Fernández-Fernández JM, Tomás M, Vázquez E, Orio P, Latorre R, Sentí M, Marrugat J, Valverde MA | title = Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension | journal = The Journal of Clinical Investigation | volume = 113 | issue = 7 | pages = 1032–1039 | date = Apr 2004 | pmid = 15057310 | pmc = 379324 | doi = 10.1172/JCI20347 | url = http://repositori.upf.edu/bitstream/10230/25630/1/Fernandez_cli_gai.pdf }}
  • {{cite journal | vauthors = Leo MD, Bannister JP, Narayanan D, Nair A, Grubbs JE, Gabrick KS, Boop FA, Jaggar JH | title = Dynamic regulation of β1 subunit trafficking controls vascular contractility | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 111 | issue = 6 | pages = 2361–2366 | date = Feb 2014 | pmid = 24464482 | pmc = 3926029 | doi = 10.1073/pnas.1317527111 | bibcode = 2014PNAS..111.2361L | doi-access = free }}
  • {{cite journal | vauthors = Kuntamallappanavar G, Toro L, Dopico AM | title = Both transmembrane domains of BK β1 subunits are essential to confer the normal phenotype of β1-containing BK channels | journal = PLOS ONE | volume = 9 | issue = 10 | pages = e109306 | year = 2014 | pmid = 25275635 | pmc = 4183656 | doi = 10.1371/journal.pone.0109306 | bibcode = 2014PLoSO...9j9306K | doi-access = free }}

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{{NLM content}}

{{Ion channels|g3}}

Category:Ion channels

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