KCNRG

KCNRG is a soluble protein with characteristics suggesting it forms hetero-tetramers with voltage-gated K⁺ channels and inhibits their function.

KCNRG has been found to be predominantly expressed in lung tissue. Additionally, KCNRG transcripts are also found in liver and some other tissues, but in lower extent.

Researchers at Uppsala University have found that KCNRG is found in the lower lung and constitutes an autoantigen in a rare disorder named autoimmune polyendocrine syndrome type 1 (APS1). As a subset of patients with APS1 suffer from respiratory disease, an autoimmune reaction against KCNRG may explain the respiratory disease in these patients. KCNRG may also be connected to common nonfatal diseases like asthma and chronic bronchitis.{{cite journal |vauthors=Alimohammadi M, Dubois N, Sköldberg F, Hallgren A, Tardivel I, Hedstrand H, Haavik J, Husebye ES, Gustafsson J, Rorsman F, Meloni A, Janson C, Vialettes B, Kajosaari M, Egner W, Sargur R, Pontén F, Amoura Z, Grimfeld A, De Luca F, Betterle C, Perheentupa J, Kämpe O, Carel JC | title = Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 106| issue = 11| pages = 4396–401|date=February 2009 | pmid = 19251657 | pmc = 2648890 | doi = 10.1073/pnas.0809986106 | bibcode = 2009PNAS..106.4396A | doi-access = free }}

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