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KCNU1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the KCa5.1 protein.{{cite journal |vauthors=Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L | title = Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes | journal = J. Biol. Chem. | volume = 273 | issue = 6 | pages = 3509–16 |date=February 1998 | pmid = 9452476 | doi = 10.1074/jbc.273.6.3509 | doi-access = free }}

Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.{{cite journal |vauthors=Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H |title=International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.|journal= Pharmacol Rev |volume= 57 |issue= 4 |pages= 463–72 |year= 2005 |pmid= 16382103 | doi = 10.1124/pr.57.4.9|s2cid=8290401}}{{cite journal |vauthors=Zhang X, Zeng X, Xia XM, Lingle CJ | title = pH-regulated Slo3 K+ channels: properties of unitary currents | journal = J. Gen. Physiol. | volume = 128 | issue = 3 | pages = 301–15 |date=September 2006 | pmid = 16940554 | pmc = 2151565 | doi = 10.1085/jgp.200609551 }}{{cite journal |vauthors=Zhang X, Zeng X, Lingle CJ | title = Slo3 K+ channels: voltage and pH dependence of macroscopic currents | journal = J. Gen. Physiol. | volume = 128 | issue = 3 | pages = 317–36 |date=September 2006 | pmid = 16940555 | pmc = 2151566 | doi = 10.1085/jgp.200609552 }}

References

{{Reflist|2}}

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).

External links

  • {{PDBe-KB2|A8MYU2|Potassium channel subfamily U member 1}}

Further reading

{{refbegin | 2}}

  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 |pmc=1356129 }}
  • {{cite journal |vauthors=Schreiber M, Wei A, Yuan A, etal |title=Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3509–16 |year= 1998 |pmid= 9452476 |doi=10.1074/jbc.273.6.3509 |doi-access=free }}
  • {{cite journal |vauthors=Nusbaum C, Mikkelsen TS, Zody MC, etal |title=DNA sequence and analysis of human chromosome 8. |journal=Nature |volume=439 |issue= 7074 |pages= 331–5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 |bibcode=2006Natur.439..331N |doi-access= free }}
  • {{cite journal |vauthors=Wei AD, Gutman GA, Aldrich R, etal |title=International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 463–72 |year= 2005 |pmid= 16382103 |doi= 10.1124/pr.57.4.9 |s2cid=8290401 }}

{{refend}}

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).

{{Ion channels|g3}}

{{gene-8-stub}}