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KCNV1

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Potassium voltage-gated channel subfamily V member 1 is a protein that in humans is encoded by the KCNV1 gene.{{cite journal |vauthors=Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattei MG, Lazdunski M | title = Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels | journal = EMBO J | volume = 15 | issue = 13 | pages = 3322–31 |date=Aug 1996 | pmid = 8670833 | pmc = 451895 | doi = 10.1002/j.1460-2075.1996.tb00697.x}}{{cite journal |vauthors=Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X | title = International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels | journal = Pharmacol Rev | volume = 57 | issue = 4 | pages = 473–508 |date=Dec 2005 | pmid = 16382104 | doi = 10.1124/pr.57.4.10 | s2cid = 219195192 }} The protein encoded by this gene is a voltage-gated potassium channel subunit.

Common variations in the KCNV1 gene have been associated with schizophrenia.{{Cite journal|last=Schizophrenia Working Group of the Psychiatric Genomics Consortium|date=2014-07-24|title=Biological insights from 108 schizophrenia-associated genetic loci|journal=Nature|volume=511|issue=7510|pages=421–427|doi=10.1038/nature13595|issn=1476-4687|pmc=4112379|pmid=25056061|bibcode=2014Natur.511..421S}}

References

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Further reading

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  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Sano A, Mikami M, Nakamura M, etal |title=Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy. |journal=Epilepsia |volume=43 |pages= 26–31 |year= 2002 |issue=Suppl 9 |pmid= 12383276 |doi= 10.1046/j.1528-1157.43.s.9.7.x|s2cid=39236204 |doi-access=free }}
  • {{cite journal |vauthors=Ebihara M, Ohba H, Kikuchi M, Yoshikawa T |title=Structural characterization and promoter analysis of human potassium channel Kv8.1 (KCNV1) gene. |journal=Gene |volume=325 |pages= 89–96 |year= 2004 |pmid= 14697513 |doi=10.1016/j.gene.2003.09.044 }}
  • {{cite journal |vauthors=Salinas M, de Weille J, Guillemare E, etal |title=Modes of regulation of shab K+ channel activity by the Kv8.1 subunit. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8774–80 |year= 1997 |pmid= 9079713 |doi=10.1074/jbc.272.13.8774 |doi-access=free }}

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External links

  • {{MeshName|Kv8.1+Potassium+Channel}}
  • {{MeshName|KCNV1+protein,+human}}

{{Ion channels|g3}}

Category:Ion channels

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