KDM4D
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene.{{cite journal | vauthors = Katoh M, Katoh M | title = Identification and characterization of JMJD2 family genes in silico | journal = International Journal of Oncology | volume = 24 | issue = 6 | pages = 1623–8 | date = June 2004 | pmid = 15138608 | doi = 10.3892/ijo.25.3.759 }}{{cite web | title = Entrez Gene: JMJD2D jumonji domain containing 2D| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55693}} KDM4D belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.
In 2017, messenger RNA from this gene was used in the somatic cell nuclear transfer experiment that produced the first two cloned primates from post-embryonic donor material.{{cite journal | vauthors = Liu Z, Cai Y, Wang Y, Nie Y, Zhang C, Xu Y, Zhang X, Lu Y, Wang Z, Poo M, Sun Q | title = Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer | journal = Cell | volume = 172 | issue = 4 | pages = 881–887.e7 | date = February 2018 | pmid = 29395327 | doi = 10.1016/j.cell.2018.01.020 | doi-access = free }}{{cite journal | url = https://www.npr.org/sections/health-shots/2018/01/24/579925801/chinese-scientists-clone-monkeys-using-method-that-created-dolly-the-sheep |title = Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep | first = Rob | last = Stein | name-list-style = vanc | journal = National Public Radio | date = 24 January 2018 | access-date = 24 January 2018 }} A similar experiment was carried out to increase the cloning efficiency of bovine species in 2018.{{cite journal | vauthors = Liu X, Wang Y, Gao Y, Su J, Zhang J, Xing X, Zhou C, Yao K, An Q, Zhang Y | title = H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming | journal = Development | volume = 145 | issue = 4 | date = February 2018 | pages = dev158261 | pmid = 29453221 | doi = 10.1242/dev.158261 | doi-access = free }}
{{wikinews|Healthy cloned monkeys born in Shanghai}}
References
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Further reading
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- {{cite journal | vauthors = Shin S, Janknecht R | title = Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D | journal = Biochemical and Biophysical Research Communications | volume = 359 | issue = 3 | pages = 742–6 | date = August 2007 | pmid = 17555712 | doi = 10.1016/j.bbrc.2007.05.179 }}
- {{cite journal | vauthors = Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y | title = Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases | journal = Cell | volume = 125 | issue = 3 | pages = 467–81 | date = May 2006 | pmid = 16603238 | doi = 10.1016/j.cell.2006.03.028 | s2cid = 14461740 | doi-access = free }}
- {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
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{{Dioxygenases}}
{{Enzymes}}
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