KIF2A
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{cs1 config|name-list-style=vanc}}
{{Infobox_gene}}
Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene.{{cite journal | vauthors = Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D | title = Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique | journal = Genomics | volume = 42 | issue = 1 | pages = 67–73 | date = May 1997 | pmid = 9177777 | doi = 10.1006/geno.1997.4720 }}{{cite web | title = Entrez Gene: KIF2A kinesin heavy chain member 2A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3796}} In mice, KIF2A is essential for proper neurogenesis and deficiency of KIF2A in mature neurons results in the loss of those neurons.{{cite journal | vauthors = Ruiz-Reig N, Chehade G, Hakanen J, Aittaleb M, Wierda K, De Wit J, Nguyen L, Gailly P, Tissir F | display-authors = 6 | title = KIF2A deficiency causes early-onset neurodegeneration | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 119 | issue = 46 | pages = e2209714119 | date = November 2022 | pmid = 36343267 | pmc = 9674219 | doi = 10.1073/pnas.2209714119 | doi-access = free | bibcode = 2022PNAS..11909714R }}
Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM]{{cite web | title = Entrez Gene: KIF2A kinesin heavy chain member 2A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3796}}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA | title = The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells | journal = Molecular Biology of the Cell | volume = 18 | issue = 8 | pages = 2970–2979 | date = August 2007 | pmid = 17538014 | pmc = 1949365 | doi = 10.1091/mbc.E07-02-0110 }}
- {{cite journal | vauthors = Schepis A, Stauber T, Krijnse Locker J | title = Kinesin-1 plays multiple roles during the vaccinia virus life cycle | journal = Cellular Microbiology | volume = 9 | issue = 8 | pages = 1960–1973 | date = August 2007 | pmid = 17394562 | doi = 10.1111/j.1462-5822.2007.00927.x | s2cid = 23205204 | doi-access = free }}
- {{cite journal | vauthors = Li C, Zheng Y, Qin W, Tao R, Pan Y, Xu Y, Li X, Gu N, Feng G, He L | display-authors = 6 | title = A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia | journal = Neuroscience Letters | volume = 407 | issue = 2 | pages = 151–155 | date = October 2006 | pmid = 16959419 | doi = 10.1016/j.neulet.2006.08.025 | s2cid = 32742823 }}
- {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–5396 | date = April 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | doi-access = free | bibcode = 2006PNAS..103.5391N }}
- {{cite journal | vauthors = Ganem NJ, Upton K, Compton DA | title = Efficient mitosis in human cells lacking poleward microtubule flux | journal = Current Biology | volume = 15 | issue = 20 | pages = 1827–1832 | date = October 2005 | pmid = 16243029 | doi = 10.1016/j.cub.2005.08.065 | s2cid = 8541946 | doi-access = free | bibcode = 2005CBio...15.1827G }}
- {{cite journal | vauthors = Ganem NJ, Compton DA | title = The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK | journal = The Journal of Cell Biology | volume = 166 | issue = 4 | pages = 473–478 | date = August 2004 | pmid = 15302853 | pmc = 2172212 | doi = 10.1083/jcb.200404012 }}
- {{cite journal | vauthors = Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, Santos R, Schadt EE, Stoughton R, Shoemaker DD | display-authors = 6 | title = Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays | journal = Science | volume = 302 | issue = 5653 | pages = 2141–2144 | date = December 2003 | pmid = 14684825 | doi = 10.1126/science.1090100 | s2cid = 10007258 | citeseerx = 10.1.1.1017.9438 | bibcode = 2003Sci...302.2141J }}
{{refend}}
External links
- {{PDBe-KB2|O00139|Human Kinesin-like protein KIF2A}}
{{PDB Gallery|geneid=3796}}
{{gene-5-stub}}{{Cytoskeletal proteins}}