KIF3A

KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification.{{cite journal |vauthors=Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM | title = Novel heterotrimeric kinesin-related protein purified from sea urchin eggs | journal = Nature | volume = 366 | issue = 6452 | pages = 268–70 |date=November 1993 | pmid = 8232586 | doi = 10.1038/366268a0 | bibcode = 1993Natur.366..268C | s2cid = 4367715 }} This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein (KAP3), and it transports protein complexes, nucleic acids and organelles towards the "plus" ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intraflagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips.{{cite journal |vauthors=Rosenbaum JL, Witman GB | title = Intraflagellar transport | journal = Nat. Rev. Mol. Cell Biol. | volume = 3 | issue = 11 | pages = 813–25 |date=November 2002 | pmid = 12415299 | doi = 10.1038/nrm952 | s2cid = 12130216 }} This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.{{cite journal |vauthors=Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N | title = Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein | journal = Cell | volume = 95 | issue = 6 | pages = 829–37 |date=December 1998 | pmid = 9865700 | doi = 10.1016/S0092-8674(00)81705-5| s2cid = 62805329 | doi-access = free }}

KIF3A has been shown to interact with MAP3K10.{{cite journal |vauthors=Nagata K, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A | title = The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3 | journal = EMBO J. | volume = 17 | issue = 1 | pages = 149–58 |date=January 1998 | pmid = 9427749 | pmc = 1170366 | doi = 10.1093/emboj/17.1.149 }}

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{{Gene-5-stub}}{{Cytoskeletal proteins}}