KIF3B
{{cs1 config|name-list-style=vanc}}
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox gene|Aliases=KIAA0359}}
Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene.{{cite journal | vauthors = Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | display-authors = 6 | title = Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 4 | issue = 2 | pages = 141–50 | date = April 1997 | pmid = 9205841 | doi = 10.1093/dnares/4.2.141 | doi-access = free }}{{cite web | title = Entrez Gene: KIF3B kinesin family member 3B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9371}} KIF3B is an N-type protein that complexes with two other kinesin proteins to form two-headed anterograde motors.{{cite journal | vauthors = Hirokawa N | title = Kinesin and dynein superfamily proteins and the mechanism of organelle transport | journal = Science | volume = 279 | issue = 5350 | pages = 519–26 | date = January 1998 | pmid = 9438838 | doi = 10.1126/science.279.5350.519 | bibcode = 1998Sci...279..519H }} First, KIF3B forms a heterodimer with KIF3A (kinesin-like protein KIF3A); (KIF3A/3B), that is membrane-bound and has ATPase activity. Then KIFAP3 (KAP3, kinesin superfamily associated protein–3) binds to the tail domain to form a heterotrimeric motor. This motor has a plus end-directed microtubule sliding activity that exhibits a velocity of ~0.3 μm/s a.{{cite journal | vauthors = Hirokawa N | title = Kinesin and dynein superfamily proteins and the mechanism of organelle transport | journal = Science | volume = 279 | issue = 5350 | pages = 519–26 | date = January 1998 | pmid = 9438838 | doi = 10.1126/science.279.5350.519 | bibcode = 1998Sci...279..519H }} There are 14 kinesin protein families in the kinesin superfamily and KIF3B is part of the Kinesin-2 family, of kinesins that can all form heterotrimeric complexes.{{cite journal | vauthors = Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L | display-authors = 6 | title = A standardized kinesin nomenclature | journal = The Journal of Cell Biology | volume = 167 | issue = 1 | pages = 19–22 | date = October 2004 | pmid = 15479732 | pmc = 2041940 | doi = 10.1083/jcb.200408113 }} Expression of the three motor subunits is ubiquitous. The KIG3A/3B/KAP3 motors can transport 90 to 160 nm in diameter organelles.
There are many orthologous KIF3B genes that are expressed in Drosophila, the sea urchin, Bos taurus, Canis familiaris, Equus caballus, Felis catus, Macaca mulatta, Mus musculus, Pan troglodytes, and Rattus norvegicus.
Function
The heterotrimeric KIF3B/KIF3A/KAP3 motor machinery functions in the intracellular transport of multiple different molecules such as β-catenin and MT1-MMP.{{cite journal | vauthors = Jimbo T, Kawasaki Y, Koyama R, Sato R, Takada S, Haraguchi K, Akiyama T | title = Identification of a link between the tumour suppressor APC and the kinesin superfamily | journal = Nature Cell Biology | volume = 4 | issue = 4 | pages = 323–7 | date = April 2002 | pmid = 11912492 | doi = 10.1038/ncb779 | s2cid = 10745049 }}{{cite journal | vauthors = Wiesner C, Faix J, Himmel M, Bentzien F, Linder S | title = KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding, and extracellular matrix degradation in primary macrophages | journal = Blood | volume = 116 | issue = 9 | pages = 1559–69 | date = September 2010 | pmid = 20505159 | doi = 10.1182/blood-2009-12-257089 | doi-access = free }} KIF3B activity has been implicated with various cellular processes such as intracellular movement of organelles, intraflagellar transport, chromosome movement during mitosis and meiosis, and cellular interaction with the extracellular matrix.{{cite journal | vauthors = Scholey JM | title = Kinesin-II, a membrane traffic motor in axons, axonemes, and spindles | journal = The Journal of Cell Biology | volume = 133 | issue = 1 | pages = 1–4 | date = April 1996 | pmid = 8601599 | pmc = 2120781 | doi = 10.1083/jcb.133.1.1 }}{{cite journal | vauthors = Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L | display-authors = 6 | title = A standardized kinesin nomenclature | journal = The Journal of Cell Biology | volume = 167 | issue = 1 | pages = 19–22 | date = October 2004 | pmid = 15479732 | pmc = 2041940 | doi = 10.1083/jcb.200408113 }}
KIF3B also regulates the interaction of cancer cells with the extracellular matrix (ECM), in particular the transport of MT1-MMP to the cancer cell front is essential for collagen fiber matrix realignment and degradation.{{cite journal | vauthors = Kravtsov O, Hartley CP, Compérat EM, Iczkowski KA | title = KIF3B protein expression loss correlates with metastatic ability of prostate cancer | journal = American Journal of Clinical and Experimental Urology | volume = 7 | issue = 3 | pages = 178–181 | date = 2019 | pmid = 31317057 | pmc = 6627541 }}{{cite journal | vauthors = Stoletov K, Willetts L, Paproski RJ, Bond DJ, Raha S, Jovel J, Adam B, Robertson AE, Wong F, Woolner E, Sosnowski DL, Bismar TA, Wong GK, Zijlstra A, Lewis JD | display-authors = 6 | title = Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis | journal = Nature Communications | volume = 9 | issue = 1 | pages = 2343 | date = June 2018 | pmid = 29904055 | doi = 10.1038/s41467-018-04743-2 | pmc = 6002534 | bibcode = 2018NatCo...9.2343S | doi-access = free }}
Interactions
KIF3B has been shown to interact with the SMC3 subunit of the cohesin complex and with RAB4A.{{cite journal | vauthors = Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM | title = Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin | journal = Molecular and Cellular Biology | volume = 23 | issue = 14 | pages = 4892–900 | date = July 2003 | pmid = 12832475 | pmc = 162221 | doi = 10.1128/MCB.23.14.4892-4900.2003 }}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Yamazaki H, Nakata T, Okada Y, Hirokawa N | title = KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport | journal = The Journal of Cell Biology | volume = 130 | issue = 6 | pages = 1387–99 | date = September 1995 | pmid = 7559760 | pmc = 2120571 | doi = 10.1083/jcb.130.6.1387 }}
- {{cite journal | vauthors = Nagata K, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A | display-authors = 6 | title = The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3 | journal = The EMBO Journal | volume = 17 | issue = 1 | pages = 149–58 | date = January 1998 | pmid = 9427749 | pmc = 1170366 | doi = 10.1093/emboj/17.1.149 }}
- {{cite journal | vauthors = Shimizu K, Shirataki H, Honda T, Minami S, Takai Y | title = Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide | journal = The Journal of Biological Chemistry | volume = 273 | issue = 12 | pages = 6591–4 | date = March 1998 | pmid = 9506951 | doi = 10.1074/jbc.273.12.6591 | doi-access = free}}
- {{cite journal | vauthors = Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N | display-authors = 6 | title = Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein | journal = Cell | volume = 95 | issue = 6 | pages = 829–37 | date = December 1998 | pmid = 9865700 | doi = 10.1016/S0092-8674(00)81705-5 | s2cid = 62805329 | doi-access = free }}
- {{cite journal | vauthors = Navarro E, Espinosa L, Adell T, Torà M, Berrozpe G, Real FX | title = Expressed sequence tag (EST) phenotyping of HT-29 cells: cloning of ser/thr protein kinase EMK1, kinesin KIF3B, and of transcripts that include Alu repeated elements | journal = Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | volume = 1450 | issue = 3 | pages = 254–64 | date = July 1999 | pmid = 10395937 | doi = 10.1016/S0167-4889(99)00051-8 | doi-access = }}
- {{cite journal | vauthors = Whitehead JL, Wang SY, Bost-Usinger L, Hoang E, Frazer KA, Burnside B | title = Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina | journal = Experimental Eye Research | volume = 69 | issue = 5 | pages = 491–503 | date = November 1999 | pmid = 10548469 | doi = 10.1006/exer.1999.0724 }}
- {{cite journal | vauthors = Jimbo T, Kawasaki Y, Koyama R, Sato R, Takada S, Haraguchi K, Akiyama T | title = Identification of a link between the tumour suppressor APC and the kinesin superfamily | journal = Nature Cell Biology | volume = 4 | issue = 4 | pages = 323–7 | date = April 2002 | pmid = 11912492 | doi = 10.1038/ncb779 | s2cid = 10745049 }}
- {{cite journal | vauthors = Baker SA, Freeman K, Luby-Phelps K, Pazour GJ, Besharse JC | title = IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia | journal = The Journal of Biological Chemistry | volume = 278 | issue = 36 | pages = 34211–8 | date = September 2003 | pmid = 12821668 | doi = 10.1074/jbc.M300156200 | doi-access = free }}
- {{cite journal | vauthors = Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM | title = Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin | journal = Molecular and Cellular Biology | volume = 23 | issue = 14 | pages = 4892–900 | date = July 2003 | pmid = 12832475 | pmc = 162221 | doi = 10.1128/MCB.23.14.4892-4900.2003 }}
- {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | display-authors = 6 | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = July 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
- {{cite journal | vauthors = Haraguchi K, Hayashi T, Jimbo T, Yamamoto T, Akiyama T | title = Role of the kinesin-2 family protein, KIF3, during mitosis | journal = The Journal of Biological Chemistry | volume = 281 | issue = 7 | pages = 4094–9 | date = February 2006 | pmid = 16298999 | doi = 10.1074/jbc.M507028200 | doi-access = free }}
- {{cite journal | vauthors = Wu Y, Dai XQ, Li Q, Chen CX, Mai W, Hussain Z, Long W, Montalbetti N, Li G, Glynne R, Wang S, Cantiello HF, Wu G, Chen XZ | display-authors = 6 | title = Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin | journal = Human Molecular Genetics | volume = 15 | issue = 22 | pages = 3280–92 | date = November 2006 | pmid = 17008358 | doi = 10.1093/hmg/ddl404 | doi-access = free }}
{{refend}}