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KLC1

{{short description|Gene of the kinesin light chain family}}

{{Infobox_gene}}

Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene.{{cite journal |vauthors=Cabeza-Arvelaiz Y, Shih LC, Hardman N, Asselbergs F, Bilbe G, Schmitz A, White B, Siciliano MJ, Lachman LB | title = Cloning and genetic characterization of the human kinesin light-chain (KLC) gene | journal = DNA Cell Biol | volume = 12 | issue = 10 | pages = 881–92 |date=Feb 1994 | pmid = 8274221 | doi = 10.1089/dna.1993.12.881}}{{cite journal |vauthors=Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS | title = Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein | journal = Cell | volume = 103 | issue = 4 | pages = 583–94 |date=Jan 2001 | pmid = 11106729 | doi =10.1016/S0092-8674(00)00162-8 | doi-access = free }}{{cite web | title = Entrez Gene: KNS2 kinesin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3831}}

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined.

Interactions

KLC1 has been shown to interact with MAPK8IP3, KIF5B{{cite journal |last=Diefenbach |first=Russell J |author2=Diefenbach Eve |author3=Douglas Mark W |author4=Cunningham Anthony L |date=Dec 2002 |title=The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23 |journal=Biochemistry |volume=41 |issue=50 |pages=14906–15 | issn = 0006-2960| pmid = 12475239 |doi=10.1021/bi026417u }}{{cite journal |last=Rahman |first=A |author2=Friedman D S |author3=Goldstein L S |date=Jun 1998 |title=Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins |journal=J. Biol. Chem. |volume=273 |issue=25 |pages=15395–403 | issn = 0021-9258| pmid = 9624122 |doi=10.1074/jbc.273.25.15395 |doi-access=free }}{{cite journal |last=Rahman |first=A |author2=Kamal A |author3=Roberts E A |author4=Goldstein L S |date=Sep 1999 |title=Defective kinesin heavy chain behavior in mouse kinesin light chain mutants |journal=J. Cell Biol. |volume=146 |issue=6 |pages=1277–88 | issn = 0021-9525| pmid = 10491391 |doi=10.1083/jcb.146.6.1277 |pmc=2156125 }} and KIF5A.

References

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Further reading

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  • {{cite journal |vauthors=Miki H, Okada Y, Hirokawa N |title=Analysis of the kinesin superfamily: insights into structure and function |journal=Trends Cell Biol. |volume=15 |issue= 9 |pages= 467–76 |year= 2005 |pmid= 16084724 |doi= 10.1016/j.tcb.2005.07.006 }}
  • {{cite journal |vauthors=Goedert M, Marsh S, Carter N |title=Localization of the human kinesin light chain gene (KNS2) to chromosome 14q32.3 by fluorescence in situ hybridization |journal=Genomics |volume=32 |issue= 1 |pages= 173–5 |year= 1996 |pmid= 8786116 |doi= 10.1006/geno.1996.0102 }}
  • {{cite journal |vauthors=Chernajovsky Y, Brown A, Clark J |title=Human kinesin light (beta) chain gene: DNA sequence and functional characterization of its promoter and first exon |journal=DNA Cell Biol. |volume=15 |issue= 11 |pages= 965–74 |year= 1997 |pmid= 8945637 |doi=10.1089/dna.1996.15.965 }}
  • {{cite journal | author=Khodjakov A |title=A specific light chain of kinesin associates with mitochondria in cultured cells |journal=Mol. Biol. Cell |volume=9 |issue= 2 |pages= 333–43 |year= 1998 |pmid= 9450959 |doi= 10.1091/mbc.9.2.333| pmc=25259 |name-list-style=vanc| author2=Lizunova EM | author3=Minin AA | display-authors=3 | last4=Koonce | first4=MP | last5=Gyoeva | first5=FK }}
  • {{cite journal |vauthors=Rahman A, Friedman DS, Goldstein LS |title=Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15395–403 |year= 1998 |pmid= 9624122 |doi=10.1074/jbc.273.25.15395 |doi-access=free }}
  • {{cite journal |vauthors=Gyoeva FK, Bybikova EM, Minin AA |title=An isoform of kinesin light chain specific for the Golgi complex |journal=J. Cell Sci. |volume=113 |issue= 11|pages= 2047–54 |year= 2000 |doi=10.1242/jcs.113.11.2047 |pmid= 10806115 }}
  • {{cite journal | author=Kamal A |title=Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I |journal=Neuron |volume=28 |issue= 2 |pages= 449–59 |year= 2001 |pmid= 11144355 |doi=10.1016/S0896-6273(00)00124-0 |name-list-style=vanc| author2=Stokin GB | author3=Yang Z | display-authors=3 | last4=Xia | first4=Chun-Hong | last5=Goldstein | first5=Lawrence S.B |doi-access=free}}
  • {{cite journal | author=Verhey KJ |title=Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules |journal=J. Cell Biol. |volume=152 |issue= 5 |pages= 959–70 |year= 2001 |pmid= 11238452 |doi=10.1083/jcb.152.5.959 | pmc=2198804 |name-list-style=vanc| author2=Meyer D | author3=Deehan R | display-authors=3 | last4=Blenis | first4=J. | last5=Schnapp | first5=B. J. | last6=Rapoport | first6=T. A. | last7=Margolis | first7=B. }}
  • {{cite journal |vauthors=Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL |title=The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23 |journal=Biochemistry |volume=41 |issue= 50 |pages= 14906–15 |year= 2003 |pmid= 12475239 |doi=10.1021/bi026417u }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Behrends U |title=Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries |journal=Int. J. Cancer |volume=106 |issue= 2 |pages= 244–51 |year= 2003 |pmid= 12800201 |doi= 10.1002/ijc.11208 |name-list-style=vanc| author2=Schneider I | author3=Rössler S | display-authors=3 | last4=Frauenknecht | first4=Heinrich | last5=Golbeck | first5=Anja | last6=Lechner | first6=Brigitte | last7=Eigenstetter | first7=Gerhard | last8=Zobywalski | first8=Colette | last9=Müller-Weihrich | first9=Stephan | doi-access=free }}
  • {{cite journal |vauthors=McCart AE, Mahony D, Rothnagel JA |title=Alternatively spliced products of the human kinesin light chain 1 (KNS2) gene |journal=Traffic |volume=4 |issue= 8 |pages= 576–80 |year= 2004 |pmid= 12839500 |doi= 10.1034/j.1600-0854.2003.00113.x|doi-access=free }}
  • {{cite journal | author=Suzuki Y |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 |name-list-style=vanc| author2=Yamashita R | author3=Shirota M | display-authors=3 | last4=Sakakibara | first4=Y | last5=Chiba | first5=J | last6=Mizushima-Sugano | first6=J | last7=Nakai | first7=K | last8=Sugano | first8=S }}
  • {{cite journal | author=Dhaenens CM |title=Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease |journal=Neurosci. Lett. |volume=368 |issue= 3 |pages= 290–2 |year= 2005 |pmid= 15364413 |doi= 10.1016/j.neulet.2004.07.040 |name-list-style=vanc| author2=Van Brussel E | author3=Schraen-Maschke S | display-authors=3 | last4=Pasquier | first4=F | last5=Delacourte | first5=A | last6=Sablonniere | first6=B |s2cid=25039113 }}
  • {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Benzinger A |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 |name-list-style=vanc| author2=Muster N | author3=Koch HB | display-authors=3 | last4=Yates Jr | last5=Hermeking | first5=H |doi-access=free }}
  • {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-style=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
  • {{cite journal|author=Pernigo S|title=Structural basis for kinesin-1:cargo recognition|journal=Science|volume=340|issue=6130|pages=356–359|year=2013|pmid=23519214|doi=10.1126/science.1234264|pmc=3693442|author2=Lamprecht A|author3=Steiner RA|author4=Dodding MP|bibcode=2013Sci...340..356P}}

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