KSR1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{for multi|the KSR1 supercomputer|Kendall Square Research}}
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Kinase suppressor of Ras 1 is an enzyme that in humans is encoded by the KSR1 gene.{{cite journal |vauthors=Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM | title = KSR, a novel protein kinase required for RAS signal transduction | journal = Cell | volume = 83 | issue = 6 | pages = 879–88 |date=Jan 1996 | pmid = 8521512 | doi =10.1016/0092-8674(95)90204-X | s2cid = 16975824 | doi-access = free }}{{cite web | title = Entrez Gene: KSR1 kinase suppressor of ras 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8844}}
References
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Further reading
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- {{cite journal |vauthors=Goettel JA, Liang D, Hilliard VC, etal |title=KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1 |journal=Exp. Cell Res. |volume=317 |issue= 4 |pages= 452–63 |year= 2011 |pmid= 21144847 |doi= 10.1016/j.yexcr.2010.11.018 | pmc=3038243 }}
- {{cite journal |vauthors=Kolesnick R, Xing HR |title=Inflammatory bowel disease reveals the kinase activity of KSR1 |journal=J. Clin. Invest. |volume=114 |issue= 9 |pages= 1233–7 |year= 2004 |pmid= 15520853 |doi= 10.1172/JCI23441 | pmc=524240 }}
- {{cite journal |vauthors=Xing HR, Lozano J, Kolesnick R |title=Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17276–80 |year= 2000 |pmid= 10764733 |doi= 10.1074/jbc.C900989199 |doi-access=free }}
- {{cite journal |vauthors=Roy F, Therrien M |title=MAP kinase module: the Ksr connection |journal=Curr. Biol. |volume=12 |issue= 9 |pages= R325–7 |year= 2002 |pmid= 12007434 |doi=10.1016/S0960-9822(02)00831-X |s2cid=17763459 |doi-access=free |bibcode=2002CBio...12.R325R }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Matheny SA, Chen C, Kortum RL, etal |title=Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP |journal=Nature |volume=427 |issue= 6971 |pages= 256–60 |year= 2004 |pmid= 14724641 |doi= 10.1038/nature02237 |bibcode=2004Natur.427..256M |s2cid=4416552 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Kim M, Yan Y, Kortum RL, etal |title=Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity |journal=Cancer Res. |volume=65 |issue= 10 |pages= 3986–92 |year= 2005 |pmid= 15899786 |doi= 10.1158/0008-5472.CAN-03-2334 |doi-access= free }}
- {{cite journal |vauthors=Zody MC, Garber M, Adams DJ, etal |title=DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage |journal=Nature |volume=440 |issue= 7087 |pages= 1045–9 |year= 2006 |pmid= 16625196 |doi= 10.1038/nature04689 | pmc=2610434 |bibcode=2006Natur.440.1045Z }}
- {{cite journal |vauthors=Wang X, Wang TT, White JH, Studzinski GP |title=Induction of kinase suppressor of RAS-1(KSR-1) gene by1, α25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5′-flanking region |journal=Oncogene |volume=25 |issue= 53 |pages= 7078–85 |year= 2006 |pmid= 16732322 |doi= 10.1038/sj.onc.1209697 | pmc=2843694 }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
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{{Serine/threonine-specific protein kinases}}
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