Kathryn Moore
{{Short description|Canadian microbiologist}}
{{Infobox scientist
| name = Kathryn J. Moore
| image = Kathryn Moore2.jpg
| fields = Atherosclerosis and Inflammation
| workplaces = Harvard Medical School
New York University Langone Medical Center
| alma_mater = McGill University
| thesis_title = Regulation of macrophage function during intracellular infection with Leishmania donovani.
| thesis_url = http://www.worldcat.org/oclc/1006638562
| thesis_year = 1994
| doctoral_advisor = Greg Matlashewski
| known_for = Atherosclerosis
| awards = National Institutes of Health R35 Outstanding Investigator Award
Fellow of the National Academy of Sciences
American Heart Association Distinguished Scientist Award
| website = https://kathrynmoorelab.com/
}}
Kathryn J. Moore is a Canadian-born American biomedical scientist and cell biologist. She is the Jean and David Blechman Professor of Cardiology and the founding director of the Cardiovascular Research Center{{Cite web |title=Cardiovascular Research Center |url=https://med.nyu.edu/departments-institutes/medicine/divisions/cardiology/research/cardiovascular-research-center |access-date=2022-11-02 |website=NYU Langone Health |language=en}} at the New York University Grossman School of Medicine. Moore's research considers the pathogenesis of atherosclerosis, with a focus on the identification of novel therapeutic targets. She was elected Fellow of the National Academy of Sciences in 2021.{{Cite web |title=2021 NAS Election |url=http://www.nasonline.org/news-and-multimedia/news/2021-nas-election.html |access-date=2021-05-03 |website=www.nasonline.org}}
Early life and education
Kathryn Moore was born in Montreal, Quebec, Canada, where she attended McGill University. Moore studied microbiology, receiving her BSc (Distinction) from McGill University in 1989. She remained there for graduate studies, studying mechanisms by which the intracellular pathogen Leishmania donovani subverts macrophage microbicidal functions,{{Cite journal |last=Moore |first=K. J. |last2=Labrecque |first2=S. |last3=Matlashewski |first3=G. |date=1993-05-15 |title=Alteration of Leishmania donovani infection levels by selective impairment of macrophage signal transduction |url=https://pubmed.ncbi.nlm.nih.gov/8482844/ |journal=Journal of Immunology |volume=150 |issue=10 |pages=4457–4465 |issn=0022-1767 |pmid=8482844}}{{Cite journal |last=Moore |first=K. J. |last2=Turco |first2=S. J. |last3=Matlashewski |first3=G. |date=Jan 1994 |title=Leishmania donovani infection enhances macrophage viability in the absence of exogenous growth factor |url=https://pubmed.ncbi.nlm.nih.gov/8283144/ |journal=Journal of Leukocyte Biology |volume=55 |issue=1 |pages=91–98 |doi=10.1002/jlb.55.1.91 |issn=0741-5400 |pmid=8283144}}{{Cite journal |last=Moore |first=K. J. |last2=Matlashewski |first2=G. |date=1994-03-15 |title=Intracellular infection by Leishmania donovani inhibits macrophage apoptosis |url=https://pubmed.ncbi.nlm.nih.gov/8144893/ |journal=Journal of Immunology |volume=152 |issue=6 |pages=2930–2937 |issn=0022-1767 |pmid=8144893}} under the Canadian immunologist Greg Matlashewski. Moore was awarded her PhD in parasitology in 1994.{{cite web |title=Kathryn J. Moore |url=http://www.nasonline.org/member-directory/members/20051969.html |website=National Academy of Sciences Member Directory |access-date=5 May 2023}}
Research and career
Moore joined the Harvard Medical School faculty as an Instructor in Medicine in 1999 and was promoted to Assistant Professor in 2002. Her early research focused on innate immune mechanisms of chronic inflammation in age-related diseases such as atherosclerosis and Alzheimer’s Disease.{{Cite web |title=New way discovered to block inflammation |url=https://www.sciencedaily.com/releases/2013/07/130701135556.htm |access-date=2024-07-31 |website=ScienceDaily |language=en}}
In 2009, Moore was recruited to the New York University Langone Medical Center, where she continued to focus on origins of cardiovascular and metabolic diseases, in particular the roles that chronic inflammation and lipid dysregulation play in these processes.{{Cite web |title=Kathryn J. Moore |url=https://med.nyu.edu/faculty/kathryn-j-moore |access-date=2024-07-31 |website=med.nyu.edu |language=en}} She contributed to seminal studies showing that cholesterol crystals in atherosclerotic plaques cause lysosomal damage that activates the NLRP3 inflammasome to promote the maturation and release of interleukin-1b.
Awards and honors
- 2003 Ellison Medical Foundation New Scholar in Aging Award{{Cite web |title=EMF: New Scholar Award in Aging: Kathryn J. Moore Ph.D. |url=https://www.ellison-med-fn.org/emf_award.jsp?award_id=272 |access-date=2022-11-04 |website=www.ellison-med-fn.org}}
- 2006 Claflin Distinguished Scholar Award{{Cite web |title= Claflin Distinguished Scholars Past Recipients |url=https://ecor.mgh.harvard.edu/Default.aspx?node_id=552 |access-date=2022-11-04 |website=MGH Executive Committee On Research}}
- 2009 American Heart Association Special Recognition Award in Vascular Biology{{Cite web |title=ATVB Special Recognition Awards |url=https://professional.heart.org/en/partners/awards-and-lectures/mid-career-achievement-awards/atvb-special-recognition-awards |access-date=2022-11-04 |website=professional.heart.org |language=en}}
- 2012 Jeffrey M. Hoeg Award for Basic Science and Clinical Research{{Cite web |title=Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award for Basic Science and Clinical Research |url=https://professional.heart.org/en/partners/awards-and-lectures/mid-career-achievement-awards/jeffrey-m-hoeg-award-for-basic-science-and-clinical-research |access-date=2022-11-04 |website=professional.heart.org |language=en}}
- 2018 ATVB Mentor of Women Award{{Cite web |title=Professional Heart Daily |url=https://professional.heart.org/en/ |access-date=2023-09-13 |website=professional.heart.org |language=en}}
- 2019 Web of Science List of Most Highly Cited Researchers{{Cite web |title=Highly Cited Researchers |url=https://publons.com/wos-op/awards/highly-cited/2019/ |access-date=2023-09-24 |website=publons.com}}
- 2020 Web of Science List of Most Highly Cited Researchers{{Cite web |title=Highly Cited Researchers |url=https://publons.com/wos-op/awards/highly-cited/2020/ |access-date=2023-09-24 |website=publons.com}}
- 2020 ATVB George Lyman Duff Memorial Lecture Award{{Cite web |title=George Lyman Duff Memorial Lecture |url=https://professional.heart.org/en/partners/awards-and-lectures/lectures/george-lyman-duff-memorial-lecture |access-date=2023-09-14 |website=professional.heart.org |language=en}}
- 2021 Web of Science List of Most Highly Cited Researchers{{Cite web |title=Highly Cited Researchers |url=https://publons.com/wos-op/awards/highly-cited/2021/ |access-date=2023-09-24 |website=publons.com}}
- 2021 ATVB Distinguished Scientist Award{{Cite web |title=Kathryn J. Moore, Ph.D., FAHA, named the American Heart Association’s 2021 Distinguished Scientist in Arteriosclerosis, Thrombosis and Vascular Biology |url=https://newsroom.heart.org/news/kathryn-j-moore-ph-d-faha-named-the-american-heart-associations-2021-distinguished-scientist-in-arteriosclerosis-thrombosis-and-vascular-biology |access-date=2023-09-14 |website=American Heart Association |language=en-us}}
- 2021 Elected Fellow of the National Academy of Sciences
- 2022 Gill Heart and Vascular Institute Award for Outstanding Contributions to Cardiovascular Research{{Cite web |date=2022-03-16 |title=Gill Foundation Honors Excellence in Cardiovascular Medicine, Research |url=https://uknow.uky.edu/professional-news/gill-foundation-honors-excellence-cardiovascular-medicine-research |access-date=2023-09-24 |website=UKNow}}{{Cite web |title=Internal Medicine {{!}} The Gill Awards {{!}} University of Kentucky College of Medicine |url=https://medicine.uky.edu/departments/internalmedicine/gill-awards |access-date=2023-09-24 |website=medicine.uky.edu}}
- 2024 Grand Prix scientifique de la Fondation Lefoulon-Delalande{{Cite web |title=Grand Prix de la Fondation Lefoulon-Delalande 2024 |url=https://www.fondation-lefoulon-delalande.fr/actualites/les-grands-prix-de-lefoulon-delalande-2024/ |access-date=2024-06-05 |website=Fondation Lefoulon-Delalande |language=fr-FR}}{{Cite web |last=Cortigiano |first=Cameron |date=2024-06-18 |title=Dr. Kathryn Moore awarded for cardiovascular physiology research |url=https://www.beckersasc.com/cardiology/dr-kathryn-moore-awarded-for-cardiovascular-physiology-research.html |access-date=2024-07-29 |website=www.beckersasc.com |language=en-gb}}
References
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Category:Year of birth missing (living people)
Category:Canadian microbiologists
Category:New York University faculty
Category:Members of the United States National Academy of Sciences
Category:McGill University alumni
Category:American microbiologists
Category:American Heart Association
Category:Harvard Medical School people
Category:New York University Grossman School of Medicine faculty