Katrina Miranda
{{Short description|American biochemist}}
{{Infobox scientist
| name = Katrina Miranda
| workplaces = University of Arizona
National Cancer Institute
University of New Mexico School of Medicine
| alma_mater = Northern Arizona University
University of California, Santa Barbara
| awards = PECASE (2008)
}}
Katrina Miranda is an associate professor of biochemistry at the University of Arizona. She works on nitric oxide and their role in diseases like breast cancer, stroke and chronic pain.
Early life and education
Miranda studied chemistry at Northern Arizona University.{{Cite web|url=https://cbc.arizona.edu/faculty/katrina-miranda|title=Katrina Miranda {{!}} cbc.arizona.edu|website=cbc.arizona.edu|access-date=2018-12-11|archive-date=2019-02-06|archive-url=https://web.archive.org/web/20190206221738/https://cbc.arizona.edu/faculty/katrina-miranda|url-status=live}} She moved to the University of California, Santa Barbara, and earned her PhD in 1996. Miranda was a postdoctoral fellow at the University of New Mexico School of Medicine.
Research
Miranda studies the chemical and biological basis of redox signalling agents.{{Cite journal|last=Vázquez-Torres|first=Andrés|date=November 2012|title=Redox Active Thiol Sensors of Oxidative and Nitrosative Stress|journal=Antioxidants & Redox Signaling|volume=17|issue=9|pages=1201–1214|doi=10.1089/ars.2012.4522|pmid=22257022|pmc=3430479|issn=1523-0864}} She was a National Institutes of Health postdoctoral fellow at the National Cancer Institute from 1998 to 2002, before joining the University of Arizona.{{Cite web|url=https://uanews.arizona.edu/story/chemistry-professor-honored-in-washington-d-c|title=Chemistry Professor Honored in Washington, D.C.|last1=Blue|first1=Alexis|last2=Communications|first2=University|website=UANews|date=5 January 2009 |access-date=2018-12-11}} She looks to identify the biomarkers of disease development. They do this by investigating the molecular redox chemistry new donor systems and designing ways to detect biological signals.{{Cite journal|last1=Cheng|first1=Robert Y.S.|last2=Basudhar|first2=Debashree|last3=Ridnour|first3=Lisa A.|last4=Heinecke|first4=Julie L.|last5=Kesarwala|first5=Aparna H.|last6=Glynn|first6=Sharon|last7=Switzer|first7=Christopher H.|last8=Ambs|first8=Stefan|last9=Miranda|first9=Katrina M.|date=December 2014|title=Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways|journal=Nitric Oxide|volume=43|pages=17–28|doi=10.1016/j.niox.2014.08.003|pmid=25153034|pmc=4250314|issn=1089-8603}}{{Cite journal|last1=Johnson|first1=Gail M.|last2=Chozinski|first2=Tyler J.|last3=Gallagher|first3=Elyssia S.|last4=Aspinwall|first4=Craig A.|last5=Miranda|first5=Katrina M.|date=November 2014|title=Glutathione sulfinamide serves as a selective, endogenous biomarker for nitroxyl after exposure to therapeutic levels of donors|journal=Free Radical Biology and Medicine|volume=76|pages=299–307|doi=10.1016/j.freeradbiomed.2014.07.022|pmc=4254043|issn=0891-5849|pmid=25064322}} Nitric oxide is synthesised in the body when L-Arginine enzymatically oxidises.{{Cite web|url=https://www.bio5.org/about/scientists/katrina-m-miranda|title=Katrina M-Miranda {{!}} BIO5|website=www.bio5.org|access-date=2018-12-11|archive-date=2018-12-14|archive-url=https://web.archive.org/web/20181214065251/https://www.bio5.org/about/scientists/katrina-m-miranda|url-status=live}} Miranda looked at what happens when nitric oxides accumulate, including their impact on chronic pain, strokes and breast cancer.{{Cite web|url=https://www.benefunder.com/life-science-causes/developing-anticancer-drugs|title=Developing Anticancer Drugs {{!}} Benefunder|website=www.benefunder.com|access-date=2018-12-11|archive-date=2018-12-14|archive-url=https://web.archive.org/web/20181214070159/https://www.benefunder.com/life-science-causes/developing-anticancer-drugs|url-status=live}} She demonstrated that nitric oxide can modify how enzymes bind to metal centres. She studied the reactivity of azanone to clarify the activity of biomolecules.{{Cite web|url=https://www.nsf.gov/awards/PECASE/recip_details.jsp;jsessionid=0AD87E5DCE8FF43E22CA79F43A8C10E5?pecase_id=232|title=The Presidential Early Career Award for Scientists and Engineers: Recipient Details {{!}} NSF - National Science Foundation|website=www.nsf.gov|access-date=2018-12-11}} She published the textbook Chemical Biology of Nitric Oxide in 2008.{{Cite book|title=Chemical Biology of Nitric Oxide|last=Miranda|first=Katrina|date=2008-03-31|publisher=Garland Science|isbn=9780815341475|edition= 1st|language=English}} Her research group attach chemical moieties that can improve drug delivery. They are using gene expression, genomic and proteomic techniques to analyse the cellular effects of redox active signalling.
Miranda runs outreach activities for faculty at the Arizona Community College to take part in research in her faculty. In 2013 she developed a massive open online course with Google that would explain abstract chemistry concepts to students around the world.{{Cite web|url=https://www.uafoundation.org/about/news/articles/article_00103.shtml|title=The University of Arizona Foundation - Gift Impact Article|website=www.uafoundation.org|access-date=2018-12-11|archive-date=2018-12-14|archive-url=https://web.archive.org/web/20181214065926/https://www.uafoundation.org/about/news/articles/article_00103.shtml|url-status=live}} In 2018 she filed a class action lawsuit against the University of Arizona for gender discrimination against women professors.{{Cite web|url=https://www.chemistryworld.com/news/chemistry-prof-sues-for-20m-over-alleged-gender-discrimination/3009888.article|title=Chemistry prof sues for $20m over alleged gender discrimination|last=December 2018|first=Rebecca Trager11|website=Chemistry World|access-date=2018-12-11}} She is not the first to sue the University of Arizona; emeritus dean Patricia MacCorquodale and former dean Janice Cervelli took them to court on behalf of women deans in early 2018.{{Cite web|url=https://www.insidehighered.com/news/2018/12/04/u-arizona-being-sued-once-again-alleged-discrimination-against-women-terms-salary|title=U of Arizona is being sued once again for alleged discrimination against women in terms of salary and promotions|website=www.insidehighered.com|access-date=2018-12-11|archive-date=2018-12-07|archive-url=https://web.archive.org/web/20181207161010/http://www.insidehighered.com/news/2018/12/04/u-arizona-being-sued-once-again-alleged-discrimination-against-women-terms-salary|url-status=live}}
= Awards =
- 2014 University of Arizona College of Science Distinguished Advising Award
- 2013 Fellow of the American Association for the Advancement of Science
- 2010 Graduate/Professional Students Achievement Award for Outstanding Mentor
- 2008 Presidential Early Career Award for Scientists and Engineers
References
External links
- {{google scholar id|vw0A_UcAAAAJ}}
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{{DEFAULTSORT:Miranda, Katrina}}
Category:Year of birth missing (living people)
Category:American women biochemists
Category:University of Arizona faculty
Category:Northern Arizona University alumni
Category:University of California, Santa Barbara alumni
Category:University of New Mexico alumni
Category:American women academics
Category:21st-century American women
Category:Recipients of the Presidential Early Career Award for Scientists and Engineers