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Keratin 16

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Keratin 16 is a protein that in humans is encoded by the KRT16 gene.{{cite journal |vauthors=Rosenberg M, RayChaudhury A, Shows TB, Le Beau MM, Fuchs E | title = A group of type I keratin genes on human chromosome 17: characterization and expression | journal = Mol. Cell. Biol. | volume = 8 | issue = 2 | pages = 722–36 |date=February 1988 | pmid = 2451124 | pmc = 363198 | doi = 10.1128/mcb.8.2.722}}{{cite journal |vauthors=Rosenberg M, Fuchs E, Le Beau MM, Eddy RL, Shows TB | title = Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12 | journal = Cytogenet. Cell Genet. | volume = 57 | issue = 1 | pages = 33–8 | year = 1991 | pmid = 1713141 | doi = 10.1159/000133109}}{{cite journal |vauthors=Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW | title = New consensus nomenclature for mammalian keratins | journal = J. Cell Biol. | volume = 174 | issue = 2 | pages = 169–74 |date=July 2006 | pmid = 16831889 | pmc = 2064177 | doi = 10.1083/jcb.200603161 }}

Keratin 16 is a type I cytokeratin. It is paired with keratin 6 in a number of epithelial tissues, including nail bed, esophagus, tongue, and hair follicles. Mutations in the gene encoding this protein are associated with the genetic skin disorders including pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.{{cite journal |vauthors=Shamsher MK, Navsaria HA, Stevens HP, Ratnavel RC, Purkis PE, Kelsell DP, McLean WH, Cook LJ, Griffiths WA, Gschmeissner S | title = Novel mutations in keratin 16 gene underlie focal non-epidermolytic palmoplantar keratoderma (NEPPK) in two families | journal = Hum. Mol. Genet. | volume = 4 | issue = 10 | pages = 1875–81 |date=October 1995 | pmid = 8595410 | doi = 10.1093/hmg/4.10.1875}}

References

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External links

  • [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=pc GeneReviews/NCBI/NIH/UW entry on Pachyonychia Congenita]

Further reading

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  • {{cite journal |vauthors=Liao H, Sayers JM, Wilson NJ, etal |title=A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita |journal=J. Dermatol. Sci. |volume=48 |issue= 3 |pages= 199–205 |year= 2007 |pmid= 17719747 |doi= 10.1016/j.jdermsci.2007.07.003 }}
  • {{cite journal |vauthors=Barcelos AC, Sotto MN |title=Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions |journal=J. Cutan. Pathol. |volume=36 |issue= 6 |pages= 647–54 |year= 2009 |pmid= 19515043 |doi= 10.1111/j.1600-0560.2008.01127.x |s2cid=205816580 }}
  • {{cite journal |vauthors=Wang YN, Chang WC |title=Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun |journal=J. Biol. Chem. |volume=278 |issue= 46 |pages= 45848–57 |year= 2003 |pmid= 12954631 |doi= 10.1074/jbc.M302630200 |doi-access= free }}
  • {{cite journal |vauthors=Bai ZL, Feng YG, Tan SS, etal |title=Mutations of KRT6A are more frequent than those of KRT16 in pachyonychia congenita type 1: report of a novel and a recently reported mutation in two unrelated Chinese families |journal=Br. J. Dermatol. |volume=159 |issue= 1 |pages= 238–40 |year= 2008 |pmid= 18489596 |doi= 10.1111/j.1365-2133.2008.08603.x |s2cid=32875094 }}
  • {{cite journal |vauthors=Harris RA, Yang A, Stein RC, etal |title=Cluster analysis of an extensive human breast cancer cell line protein expression map database |journal=Proteomics |volume=2 |issue= 2 |pages= 212–23 |year= 2002 |pmid= 11840567 |doi=10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO;2-H |s2cid=44946014 }}
  • {{cite journal |vauthors=van Lingen RG, Poll MK, Seyger MM, etal |title=Distribution of dipeptidyl-peptidase IV on keratinocytes in the margin zone of a psoriatic lesion: a comparison with hyperproliferation and aberrant differentiation markers |journal=Arch. Dermatol. Res. |volume=300 |issue= 10 |pages= 561–7 |year= 2008 |pmid= 18496701 |doi= 10.1007/s00403-008-0862-1 |doi-access= free }}
  • {{cite journal |vauthors=Nishizawa M, Izawa I, Inoko A, etal |title=Identification of trichoplein, a novel keratin filament-binding protein |journal=J. Cell Sci. |volume=118 |issue= Pt 5 |pages= 1081–90 |year= 2005 |pmid= 15731013 |doi= 10.1242/jcs.01667 |doi-access= free }}
  • {{cite journal |vauthors=Bhawan J, Bansal C, Whren K, etal |title=K16 expression in uninvolved psoriatic skin: a possible marker of pre-clinical psoriasis |journal=J. Cutan. Pathol. |volume=31 |issue= 7 |pages= 471–6 |year= 2004 |pmid= 15239676 |doi= 10.1111/j.0303-6987.2004.0220.x |s2cid=20099397 }}
  • {{cite journal |vauthors=Terrinoni A, Puddu P, Didona B, etal |title=A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus |journal=J. Invest. Dermatol. |volume=114 |issue= 6 |pages= 1136–40 |year= 2000 |pmid= 10844556 |doi= 10.1046/j.1523-1747.2000.00983.x |doi-access= free }}
  • {{cite journal |vauthors=Ito Y, Kurokawa I, Nishimura K, etal |title=Keratin and filaggrin expression in keratoacanthoma |journal=J Eur Acad Dermatol Venereol |volume=22 |issue= 3 |pages= 353–5 |year= 2008 |pmid= 18005116 |doi= 10.1111/j.1468-3083.2007.02440.x |s2cid=37712127 }}
  • {{cite journal |vauthors=Smith FJ, Fisher MP, Healy E, etal |title=Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma |journal=Exp. Dermatol. |volume=9 |issue= 3 |pages= 170–7 |year= 2000 |pmid= 10839714 |doi=10.1034/j.1600-0625.2000.009003170.x |s2cid=44384231 }}
  • {{cite journal |vauthors=Yu JQ, Zhuang H, Xiu Y, etal |title=Small urine leak after renal transplantation: detection by delayed 99mTc-DTPA renography--a case report |journal=J Nucl Med Technol |volume=33 |issue= 1 |pages= 31–3 |year= 2005 |pmid= 15731018 }}
  • {{cite journal |vauthors=Wu C, Li C, Wei L, Zheng Z |title=Innate immune modulation of keratinocytes by antikeratin 16 antibodies |journal=Exp. Dermatol. |volume=17 |issue= 8 |pages= 645–52 |year= 2008 |pmid= 18557933 |doi= 10.1111/j.1600-0625.2007.00682.x |s2cid=21212353 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |pmc=528928 |doi= 10.1101/gr.2596504 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Terrinoni A, Smith FJ, Didona B, etal |title=Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita |journal=J. Invest. Dermatol. |volume=117 |issue= 6 |pages= 1391–6 |year= 2001 |pmid= 11886499 |doi= 10.1046/j.0022-202x.2001.01565.x |doi-access= free }}
  • {{cite journal |vauthors=Chen YJ, Wang YN, Chang WC |title=ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression |journal=J. Biol. Chem. |volume=282 |issue= 37 |pages= 27215–28 |year= 2007 |pmid= 17623675 |doi= 10.1074/jbc.M700264200 |doi-access= free }}
  • {{cite journal |vauthors=Connors JB, Rahil AK, Smith FJ, etal |title=Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16 |journal=Br. J. Dermatol. |volume=144 |issue= 5 |pages= 1058–62 |year= 2001 |pmid= 11359398 |doi=10.1046/j.1365-2133.2001.04199.x |s2cid=22597662 }}

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{{Cytoskeletal proteins}}

Category:Keratins

{{Gene-17-stub}}