| class="wikitable" style="margin:1em auto; font-size:90%; text-align:center;" |
| width=250 | Portfolio
! width=200 | Minister
! width=250 | Time frame
! width=200 | Notes |
|---|
| President | John Kufuor | January 2001 – January 2009 | |
| Vice President | Aliu Mahama | January 2001 – January 2009 | |
Minister for Foreign Affairs later
Minister for Foreign Affairs, Regional Integration and NEPAD[{{cite news |title=Kufuor restructures ministerial team |work=General News of Friday, 28 April 2006 |publisher=GhanaWeb |url=http://www.ghanaweb.com/GhanaHomePage/NewsArchive/artikel.php?ID=103354 |access-date=2007-05-05}}] | Nana Addo Dankwa Akufo-Addo
Akwasi Osei-Agyei
| [{{cite news |title=Twenty-nine Ministers sworn into office |work=General News of Wednesday, 2 February 2005 |publisher=GhanaWeb |url=http://www.ghanaweb.com/GhanaHomePage/NewsArchive/artikel.php?ID=74556 |access-date=2007-05-05}}] Apr 2003 – Jul 2007
[{{cite news|url=http://www.ghananewsagency.org/?s=bV4EjEpg&r=q*x9 |title=Parliament approves nominations of 12 Ministers |access-date=2007-07-30 |date=27 July 2007 |work=Politics |publisher=Ghana News Agency}}] Jul 2007 – January 2009 | |
| Minister for Interior | Papa Owusu-Ankomah
Albert Kan Dapaah
Kwamena Bartels
Kwame Addo-Kufuor | [ 2005 – 2006]
[ 2006 – 2007]
[{{cite news |url=http://www.ghananewsagency.org/?s=bV4EjEpg&r=q*nq |title=Full list of Ministers and Regional Ministers out |access-date=2007-08-02 |date=1 August 2007 |publisher=Ghana News Agency}}] 2007 – 2008
[{{cite news |title=Four "New" Ministers sworn into office |work=General News of Thursday, 12 June 2008 |publisher=GhanaWeb |url=http://www.ghanaweb.com/GhanaHomePage/NewsArchive/artikel.php?ID=145225 |access-date=2008-06-12}}] 2008 – January 2009 | |
| Minister for Finance and Economic Planning | Kwadwo Baah Wiredu
Dr. Anthony Akoto Osei | [ 2005 – 2007]
| |
| Minister for Defence | Kwame Addo-Kufuor[{{cite web |title=MINISTER FOR DEFENCE |url=http://mod.gov.gh/mod/index.php/minister-for-defence/ |website=www.mod.gov.gh |publisher=Ghana Government |access-date=19 March 2020}}]
Albert Kan Dapaah | 2001 – 2007
6 Aug 2007 – 6 Jan 2009 | |
Minister for National Security | Francis Poku | [ 2006 – January 2009] | New portfolio |
| Attorney General and Minister for Justice | J. Ayikoi Otoo
Joe Ghartey
Ambrose Dery | [ 2005 – 2006]
[ 2006 – 2007]
| |
| Minister for Health | Major Courage Quashigah (rtd) | [ 2005 – January 2009] | |
Minister for Education and Sports later Minister for Education, Science and Sports | Yaw Osafo-Maafo
Papa Owusu Ankomah
Dominic Fobi | [ 2005 – 2006]
[ 2006 – 2007]
| |
| Minister for Food and Agriculture | Ernest Akubuor Debrah | [ 2005 – January 2009] | |
| Minister for Fisheries | Gladys Asmah | [ 2005 – January 2009] | |
Minister for Trade and Industry (later)
Minister for Trade and Industry, Private Sector Development and President's Special Initiative | Alan Kyeremanteng
Joe Baidoo Ansah
Papa Owusu Ankomah | [ 2003 – 2007]
| |
| Minister for Private Sector Development & President's Special Initiative | Kwamena Bartels | [ 2005 – 2006] | Ministry merged with Trade and Industry |
Minister for Local Government and Rural Development later Minister for Local Government, Rural Development and Environment | Charles Bimpong Bintim
Stephen Asamoah-Boateng
Kwadwo Adjei-Darko | [ 2005 – 2006]
[ 2006 – 2007]
| |
Minister for Information later
Minister for Information and National Orientation | Daniel Kwaku Botwe
Kwamena Bartels
Florence Oboshie Sai-Coffie
Stephen Asamoah Boateng[{{Cite web|title=Asamoah-Boateng: There is no pressure on government|url=https://www.modernghana.com/news/166339/asamoah-boateng-there-is-no-pressure-on-governmen.html|access-date=2021-01-11|website=Modern Ghana|language=en}}]
|[ 2005 – 2006]
[ 2006 – 2007]
2008 – January 2009
| |
Minister for Tourism and Modernisation of the Capital City later
Minister for Tourism and Diasporean Relations | Jake Obetsebi Lamptey
Stephen Asamoah-Boateng
Florence Oboshie Sai-Coffie[{{Cite web |title=gh_minister |url=https://www.africa-ata.org/gh_minister.htm |access-date=2021-01-11 |website=Africa-ata}}]
|[ 2003 – 2007]
2008 – January 2009
| |
| Minister for Works and Housing later Minister for Water Resources, Works and Housing | Hackman Owusu-Agyeman
Boniface Abubakar Saddique | [ 2005 – 2007]
| |
| Minister for Public Sector Reform | Dr. Paa Kwesi Nduom (CPP)
Samuel Owusu-Agyei | [ 2005 – 2007][{{cite news |url=http://www.ghanaweb.com/GhanaHomePage/NewsArchive/artikel.php?ID=126979 |title=Nduom quits government |access-date=2007-07-11 |work=Press Review of Tuesday, 10 July 2007 |publisher=Ghana government}}]
| |
| Minister for Communication | Albert Kan Dapaah
Prof. Mike Oquaye
Dr. Ben Aggrey Ntim | [ 2005 – 2006]
[ 2006 – 2007]
| |
| Minister for Roads and Highways | Richard Winfred Anane
vacant
Godfred T. Boyon | [{{cite news |title=Anane, Edumadze, Churcher and Quaye sworn into office |work=General News of Thursday, 17 February 2005 |publisher=GhanaWeb |url=http://www.ghanaweb.com/GhanaHomePage/NewsArchive/artikel.php?ID=75596 |access-date=2007-05-05}}] 2005 – 2006
2006 – 2007
| Resigned after adverse findings against him by the CHRAJ. |
| Minister for Ports, Harbours and Railways | Prof.Christopher Ameyaw Akumfi | 2001 – January 2009 | |
Minister for Aviation | Gloria Akuffo | [ 2006 – January 2009] | Newly created ministry |
| Minister for Energy | Prof. Mike Oquaye
Joseph Kofi Adda
Felix Owusu-Adjapong | [ 2005 – 2006]
[ 2006 – 2008]
| |
| Minister for Lands, Forestry and Mines | Prof. Dominic Fobih
Esther Obeng Dapaah | [ 2003 – 2007]
| |
| Minister for Environment and Science | Christine Churcher | [ 2005 – 2006] | |
| Minister for Regional Co-Operation and NEPAD | Dr. Kofi Konadu Apraku | [ 2003 – 2006] | |
| Minister for Women and Children's Affairs | Hajia Alima Mahama | [ 2005 – January 2009] | |
Minister for Manpower Development and Employment now
Ministry for Manpower, Youth and Employment | Joseph Kofi Adda
Boniface Abubakar Saddique
Nana Akomea | [ 2005 – 2006]
[ 2006 – 2007]
| |
Minister of State for Culture and Chieftaincy[{{cite news |title=New Ministerial List: Summary |work=General News of Saturday, 13 May 2006 |publisher=GhanaWeb |url=http://www.ghanaweb.com/GhanaHomePage/NewsArchive/artikel.php?ID=103355 |access-date=2007-05-05}}] | Sampson Kwaku Boafo | [ 2006 – January 2009] | New portfolio |
| Minister for Presidential Affairs | Kwadwo Mpiani | 2005 – January 2009 | |
| Minister for Parliamentary Affairs | Felix Owusu-Adjapong
Abraham Ossei Aidooh | 2001 – 2007
| |
| Senior Minister | Joseph Henry Mensah | [ 2005 – 2006] | |
| colspan=4 |Regional Ministers |
|---|
| Ashanti Regional Minister | Sampson Kwaku Boafo
Emmanuel A. Owusu-Ansah | [ 2005 – 2006]
[ 2006 – January 2009] | |
| Brong Ahafo Region | Nana Kwadwo Seinti
Ignatius Baffour Awuah | [ 2005 – 2006]
[ 2006 – January 2009] | |
| Central Regional Minister | Isaac E. Edumadze
Nana Ato Arthur | [ 2005 – 2006]
[ 2006 – January 2009] | |
| Eastern Regional Minister | Yaw Barimah
Kwadwo Afram Asiedu | [ 2005 – 2007]
| |
| Greater Accra Regional Minister | Shiekh Ibrahim Cudjoe Quaye | [ 2005 – January 2009] | |
| Northern Regional Minister | Boniface Abubakar Saddique
Alhaji Mustapha Ali Idris | [ 2005 – 2006]
[ 2006 – January 2009] | |
| Upper East Region | Boniface Agambila
Alhassan Samari | [ 2005 – 2007]
| |
| Upper West Region | Ambrose Dery
George Hikah Benson | [ 2005 – 2007]
| |
| Volta Regional Minister | Kofi Dzamesi | [ 2005 – January 2009] | |
| Western Region | Joseph Boahen Aidoo
Evans A. Amoah | [ 2005 – 2006]
[ 2006 – January 2009] | |
There was a cabinet reshuffle on 28 April 2006.
There was a second cabinet reshuffle to release ministers with presidential ambitions in July 2007.