L-aminoadipate-semialdehyde dehydrogenase

{{infobox enzyme

| Name = L-aminoadipate-semialdehyde dehydrogenase

| EC_number = 1.2.1.31

| CAS_number = 9067-87-2

| GO_code = 0004043

| image = 4zvy.jpg

| width = 270

| caption = Alpha-aminoadipic semialdehyde dehydrogenase tetramer, Human

}}

In enzymology, a L-aminoadipate-semialdehyde dehydrogenase ({{EC number|1.2.1.31}}) is an enzyme that catalyzes the chemical reaction

:L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H₂O $\rightleftharpoons$ L-2-aminoadipate + NAD(P)H + H⁺

The 4 substrates of this enzyme are L-2-aminoadipate 6-semialdehyde, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are L-2-aminoadipate, NADH, NADPH, and H⁺.

This enzyme participates in lysine biosynthesis and biodegradation.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase. Other names in common use include:

aminoadipate semialdehyde dehydrogenase,
2-aminoadipate semialdehyde dehydrogenase,
alpha-aminoadipate-semialdehyde dehydrogenase,
alpha-aminoadipate reductase,
2-aminoadipic semialdehyde dehydrogenase,
L-alpha-aminoadipate delta-semialdehyde oxidoreductase,
L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase,
L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine,
and dinucleotide oxidoreductase.

References

{{cite journal | vauthors = Calvert AF, Rodwell VW | date = 1966 | title = Metabolism of pipecolic acid in a Pseudomonas species. 3 L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase | journal = J. Biol. Chem. | volume = 241 | pages = 409–14 | pmid = 4285660 | issue = 2 | doi = 10.1016/S0021-9258(18)96932-2 | doi-access = free }}

Category:EC 1.2.1

Category:NADPH-dependent enzymes

Category:NADH-dependent enzymes

Category:Enzymes of known structure